Protein detail
RPSA2
Small ribosomal subunit protein uS2B (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (40S ribosomal protein SA) (40S ribosomal protein SA2) (67 kDa laminin receptor) (67LR) (Laminin receptor 1) (LamR) (Laminin-binding protein precursor p40) (LBP/p40)
Entry name RPSA2 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 3 | Transmembrane count | Protein classification Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPredicted intracellular proteinsRibosomal proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Small ribosomal subunit protein uS2B (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (40S ribosomal protein SA) (40S ribosomal protein SA2) (67 kDa laminin receptor) (67LR) (Laminin receptor 1) (LamR) (Laminin-binding protein precursor p40) (LBP/p40)
Protein Class (6)
Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPredicted intracellular proteinsRibosomal proteins
Protein Function (4)
- Ribosomal proteins
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
37LRPLAMR1LRPp40SA
Gene Description
Ribosomal protein SA
Chromosome
3
Position
39406716-39426255
Supporting publications (n)
3
EVMP confidence score
0.50
Fluorescence & Localization2
Tissue Specificurinary bladderCell SpecificUrothelial cells
Function & Pathway7
Protein Function (4)
- Ribosomal proteins
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
- Predicted intracellular proteins
Cellular Component (9)
Molecular Function (8)
Biological Process (3)
Reactome (30)
- R-hsa-72662 activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-9711097 cellular response to starvation
- R-hsa-9918485 dengue virus attachment and entry
- R-hsa-9839923 dengue virus infection
- R-hsa-156842 eukaryotic translation elongation
- R-hsa-72613 eukaryotic translation initiation
- R-hsa-5663205 infectious disease
- R-hsa-168255 influenza infection
- R-hsa-168273 influenza viral rna transcription and replication
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Mediation Categories (2)
Clinical-translation mediationMetabolism mediation
Relations & Evidence134
Ligand-Receptor Signaling (32)
32 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| other_receptor_family | receptor | HPMR | No | Yes | No | Yes | No |
| non_integrin_laminin_binding_proteins | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| ecm | ecm | GO_Intercell | Yes | No | No | Yes | No |
| ecm | ecm | OmniPath | Yes | No | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
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Protein Complex Composition (101)
101 records.
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37886648 |
Sequence, Structure & Domains8
Sequences
Length
295
Mass
32,909
Sequence
MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEHYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFWEPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPSPEFTATQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTDWS
Domain & Motif Annotations
Compositional Bias
218..227; Basic and acidic residues
Repeat
230..232; [DE]-W-[ST] 1; 247..249; [DE]-W-[ST] 2; 266..268; [DE]-W-[ST] 3; 275..277; [DE]-W-[ST] 4; 293..295; [DE]-W-[ST] 5
Region
54..113; Interaction with PPP1R16B; 161..180; Laminin-binding; 205..229; Laminin-binding; 218..242; Disordered; 242..295; Laminin-binding; 266..295; Disordered
Protein Families
Universal ribosomal protein uS2 family
Sequence Similarities
Belongs to the universal ribosomal protein uS2 family.
Clinical Relevance6
Disease Involvement
Disease variant
Drugs (75)
AMIKACINCHLORAMPHENICOL SODIUM SUCCINATECLINDAMYCINDALFOPRISTINRADEZOLIDPYRAZINAMIDEERYTHROMYCIN GLUCEPTATEOXYTETRACYCLINE HYDROCHLORIDEPAROMOMYCIN SULFATEERYTHROMYCIN STEARATEDIRITHROMYCINDIHYDROSTREPTOMYCIN SULFATENEOMYCIN SULFATECAPREOMYCIN SULFATEERYTHROMYCINSPECTINOMYCIN HYDROCHLORIDETEDIZOLIDLINEZOLIDERYTHROMYCIN ACISTRATENAFITHROMYCINCHLORTETRACYCLINE HYDROCHLORIDEQUINUPRISTINCLINDAMYCIN HYDROCHLORIDECLARITHROMYCINSISOMICINSPIRAMYCINMT-3724LINCOMYCINJOSAMYCINSTREPTOMYCIN SULFATEDOXORUBICIN HYDROCHLORIDEDORLIMOMAB ARITOXERYTHROMYCIN LACTOBIONATETETRACYCLINENETILMICIN SULFATEMETHACYCLINE HYDROCHLORIDEOXYTETRACYCLINE CALCIUMKANAMYCIN SULFATETROLEANDOMYCINQUINUPRISTIN/DALFOPRISTINTELITHROMYCINLINCOMYCIN HYDROCHLORIDEOMADACYCLINE TOSYLATELEFAMULIN ACETATEMECLOCYCLINE SULFOSALICYLATEDEMECLOCYCLINE HYDROCHLORIDETETRACYCLINE HYDROCHLORIDEDELPAZOLIDBEKANAMYCINCHLORAMPHENICOLCONTEZOLID ACEFOSAMILTOBRAMYCINCYCLOHEXIMIDEATALURENEXALURENERAVACYCLINE DIHYDROCHLORIDEMITOXANTRONECHLORAMPHENICOL PALMITATETEDIZOLID PHOSPHATEVIOMYCIN SULFATEPLAZOMICIN SULFATETIGECYCLINESUTEZOLIDDAUNORUBICIN LIPOSOMALFRAMYCETINCONTEZOLIDOXYTETRACYCLINE ANHYDROUSERYTHROMYCIN ESTOLATEGENTAMICIN SULFATEAZITHROMYCINDOXYCYCLINE ANHYDROUSCADAZOLIDMINOCYCLINE HYDROCHLORIDECETHROMYCINTETRACYCLINE PHOSPHATE COMPLEX
Antibody
Interaction Protein (32)
ENSG00000065427ENSG00000071082ENSG00000083845ENSG00000102974ENSG00000105193ENSG00000105372ENSG00000108298ENSG00000112578ENSG00000115268ENSG00000118181ENSG00000121390ENSG00000122406ENSG00000124614ENSG00000130826ENSG00000131051ENSG00000137154ENSG00000138385ENSG00000140988ENSG00000142534ENSG00000142676ENSG00000142937ENSG00000145425ENSG00000149273ENSG00000167721ENSG00000171858ENSG00000174444ENSG00000174720ENSG00000182774ENSG00000198242ENSG00000204628ENSG00000231500ENSG00000265241
Interaction Count
32
Interaction Dataset (6)
intact_biogridbiogrid_bioplexbiogrid_opencell_bioplexbiogrid_opencellintact_biogrid_bioplexintact_biogrid_opencell
Supporting Publications3
| PMID | Title | Abstract |
|---|---|---|
| 34265469 | Proteomic Landscape of Exosomes Reveals the Functional Contributions of CD151 in Triple-Negative Breast Cancer. | Furthermore, utilizing quantitative proteomics approach to reveal the proteomes of CD151-deleted exosomes and cells, we found that exosomal CD151 facilitated secretion of ribosomal proteins via exosomes while inhibiting exosome secretion of complement proteins. Moreover, we proved that CD151-deleted exosomes significantly decreased the migration and invasion of TNBC cells. Most importantly, we found that the tetraspanin CD151 expression levels in TNBC-derived serum exosomes were significantly higher than those exosomes from healthy subjects, and we validated our findings with samples from 16 additional donors. This is the first comparative study of the proteomes of TNBC patient-derived and CD151-deleted exosomes. |
| 37427430 | Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis. | No abstract available |
| 40689422 | Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles. | No abstract available |