Extracellular Vesicle Membrane Proteins (EVMPs) are located on the surface of extracellular vesicles and serve as key mediators of their diverse biological functions. However, a systematic integration and functional characterization of EVMPs and their disease associations remain limited. To address this, we developed the EVMP Atlas, a comprehensive database that integrates multi-dimensional evidence for 2,176 human EVMPs and establishes a unified scoring system. Leveraging manual annotation, we constructed a functional mediation framework, categorizing EVMPs into six major modules: membrane fusion and delivery, adhesion and uptake, receptor-mediated signal transduction, immune regulation, metabolic regulation, and clinical translation. The EVMP Atlas provides a comprehensive landscape of EV membrane proteins, serving as a systematic reference for functional interpretation and potential applications in precision medicine.

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