EVMP Atlas is a comprehensive knowledgebase dedicated to human extracellular vesicle membrane proteins (EVMPs), providing systematic evidence integration, confidence scoring, functional annotation, disease association, biomarker information and drug target mapping. EVMPs reside on the surface of extracellular vesicles and play central roles in vesicle biogenesis, cargo delivery, cellular targeting, intercellular communication and disease-associated regulation. However, existing EV resources provide limited membrane-focused annotation and lack an integrated framework for interpreting the functional and translational relevance of EVMPs.
EVMP Atlas integrates multidimensional evidence for 2,176 human EVMPs through large-scale text mining and manual curation, substantially expanding the membrane-focused EV protein landscape beyond existing EV databases by adding 965 EVMPs and increasing coverage by 77%. The curated EVMPs include 732 disease-associated biomarkers and 302 drug targets, and are organized into six mechanistic and translational modules: membrane fusion and cargo delivery, adhesion and uptake, receptor-mediated signal transduction, immune regulation, metabolic regulation and clinical translation. By further comparing circulating EVMP profiles between healthy controls and patients with pan-cancer, EVMP Atlas demonstrates the potential diagnostic value of EVMPs as circulating biomarkers.
EVMP Atlas enables users to browse, search, score and interpret EVMPs across biological functions, disease contexts and translational applications, providing a curated and interpretable resource for extracellular vesicle biology, biomarker discovery, therapeutic target prioritization and precision medicine.