Protein detail
RPSA2
Small ribosomal subunit protein uS2B (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (40S ribosomal protein SA) (40S ribosomal protein SA2) (67 kDa laminin receptor) (67LR) (Laminin receptor 1) (LamR) (Laminin-binding protein precursor p40) (LBP/p40)
Protein symbol RPSA2 | UniProt ID | EVMP score 0.50 |
Frequency 3 | Transmembrane count | Protein classification Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPredicted intracellular proteinsRibosomal proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Small ribosomal subunit protein uS2B (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (40S ribosomal protein SA) (40S ribosomal protein SA2) (67 kDa laminin receptor) (67LR) (Laminin receptor 1) (LamR) (Laminin-binding protein precursor p40) (LBP/p40)
Protein Class
Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPredicted intracellular proteinsRibosomal proteins
Protein Function
- Ribosomal proteins
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
37LRPLAMR1LRPp40SA
Gene Description
Ribosomal protein SA
Chromosome
3
Position
39406716-39426255
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificurinary bladderCell SpecificUrothelial cells
Function & Pathway
Protein Function
- Ribosomal proteins
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-72662 activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-9711097 cellular response to starvation
- R-hsa-9918485 dengue virus attachment and entry
- R-hsa-9839923 dengue virus infection
- R-hsa-156842 eukaryotic translation elongation
- R-hsa-72613 eukaryotic translation initiation
- R-hsa-5663205 infectious disease
- R-hsa-168255 influenza infection
- R-hsa-168273 influenza viral rna transcription and replication
- R-hsa-71291 metabolism of amino acids and derivatives
- R-hsa-8953854 metabolism of rna
- R-hsa-9675108 nervous system development
- R-hsa-927802 nonsense mediated decay nmd
- R-hsa-9010553 regulation of expression of slits and robos
- R-hsa-9633012 response of eif2ak4 gcn2 to amino acid deficiency
- R-hsa-9948299 ribosome associated quality control
- R-hsa-72312 rrna processing
- R-hsa-9692914 sars cov 1 host interactions
- R-hsa-9678108 sars cov 1 infection
- R-hsa-9735869 sars cov 1 modulates host translation machinery
- R-hsa-9705683 sars cov 2 host interactions
- R-hsa-9694516 sars cov 2 infection
- R-hsa-9754678 sars cov 2 modulates host translation machinery
- R-hsa-9679506 sars cov infections
- R-hsa-2408522 selenoamino acid metabolism
- R-hsa-376176 signaling by robo receptors
- R-hsa-1799339 srp dependent cotranslational protein targeting to membrane
- R-hsa-72766 translation
- R-hsa-9824446 viral infection pathways
Mediation Categories
Clinical-translation mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
32 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| matrix_adhesion | matrix_adhesion | OmniPath | No | Yes | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | HPMR | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | talklr | No | Yes | No | Yes | No |
| receptor | receptor | connectomeDB2020 | No | Yes | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37886648 |
Sequence, Structure & Domains
Sequences
Length
295
Mass
32,909
Sequence
MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEHYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFWEPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPSPEFTATQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTDWS
3D Structural Models
Domain & Motif Annotations
Compositional Bias
218..227; Basic and acidic residues
Repeat
230..232; [DE]-W-[ST] 1; 247..249; [DE]-W-[ST] 2; 266..268; [DE]-W-[ST] 3; 275..277; [DE]-W-[ST] 4; 293..295; [DE]-W-[ST] 5
Region
54..113; Interaction with PPP1R16B; 161..180; Laminin-binding; 205..229; Laminin-binding; 218..242; Disordered; 242..295; Laminin-binding; 266..295; Disordered
Protein Families
Universal ribosomal protein uS2 family
Sequence Similarities
Belongs to the universal ribosomal protein uS2 family.
Clinical Relevance
Disease Involvement
Disease variant
Drugs
AMIKACINCHLORAMPHENICOL SODIUM SUCCINATECLINDAMYCINDALFOPRISTINRADEZOLIDPYRAZINAMIDEERYTHROMYCIN GLUCEPTATEOXYTETRACYCLINE HYDROCHLORIDEPAROMOMYCIN SULFATEERYTHROMYCIN STEARATEDIRITHROMYCINDIHYDROSTREPTOMYCIN SULFATENEOMYCIN SULFATECAPREOMYCIN SULFATEERYTHROMYCINSPECTINOMYCIN HYDROCHLORIDETEDIZOLIDLINEZOLIDERYTHROMYCIN ACISTRATENAFITHROMYCINCHLORTETRACYCLINE HYDROCHLORIDEQUINUPRISTINCLINDAMYCIN HYDROCHLORIDECLARITHROMYCINSISOMICINSPIRAMYCINMT-3724LINCOMYCINJOSAMYCINSTREPTOMYCIN SULFATEDOXORUBICIN HYDROCHLORIDEDORLIMOMAB ARITOXERYTHROMYCIN LACTOBIONATETETRACYCLINENETILMICIN SULFATEMETHACYCLINE HYDROCHLORIDEOXYTETRACYCLINE CALCIUMKANAMYCIN SULFATETROLEANDOMYCINQUINUPRISTIN/DALFOPRISTINTELITHROMYCINLINCOMYCIN HYDROCHLORIDEOMADACYCLINE TOSYLATELEFAMULIN ACETATEMECLOCYCLINE SULFOSALICYLATEDEMECLOCYCLINE HYDROCHLORIDETETRACYCLINE HYDROCHLORIDEDELPAZOLIDBEKANAMYCINCHLORAMPHENICOLCONTEZOLID ACEFOSAMILTOBRAMYCINCYCLOHEXIMIDEATALURENEXALURENERAVACYCLINE DIHYDROCHLORIDEMITOXANTRONECHLORAMPHENICOL PALMITATETEDIZOLID PHOSPHATEVIOMYCIN SULFATEPLAZOMICIN SULFATETIGECYCLINESUTEZOLIDDAUNORUBICIN LIPOSOMALFRAMYCETINCONTEZOLIDOXYTETRACYCLINE ANHYDROUSERYTHROMYCIN ESTOLATEGENTAMICIN SULFATEAZITHROMYCINDOXYCYCLINE ANHYDROUSCADAZOLIDMINOCYCLINE HYDROCHLORIDECETHROMYCINTETRACYCLINE PHOSPHATE COMPLEX
Antibody
Interaction Protein
ENSG00000065427ENSG00000071082ENSG00000083845ENSG00000102974ENSG00000105193ENSG00000105372ENSG00000108298ENSG00000112578ENSG00000115268ENSG00000118181ENSG00000121390ENSG00000122406ENSG00000124614ENSG00000130826ENSG00000131051ENSG00000137154ENSG00000138385ENSG00000140988ENSG00000142534ENSG00000142676ENSG00000142937ENSG00000145425ENSG00000149273ENSG00000167721ENSG00000171858ENSG00000174444ENSG00000174720ENSG00000182774ENSG00000198242ENSG00000204628ENSG00000231500ENSG00000265241
Interaction Count
32
Interaction Dataset
intact_biogridbiogrid_bioplexbiogrid_opencell_bioplexbiogrid_opencellintact_biogrid_bioplexintact_biogrid_opencell