Protein detail
SHOT1
Shootin-1 (Shootin1)
Protein symbol SHOT1 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Shootin-1 (Shootin1)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA1598shootin-1shootin1
Gene Description
Shootin 1
Chromosome
10
Position
116881477-117126586
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain Specificastrocyte
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
- GO:0005737 cytoplasm
- GO:0005874 microtubule
- GO:0005875 microtubule associated complex
- GO:0015630 microtubule cytoskeleton
- GO:0030027 lamellipodium
- GO:0030175 filopodium
- GO:0030424 axon
- GO:0030426 growth cone
- GO:0031252 cell leading edge
- GO:0043204 perikaryon
- GO:0044295 axonal growth cone
- GO:0048471 perinuclear region of cytoplasm
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SHTN1 | NTN1 | O95631 | S | 249 | phosphorylation | RLIMS-P_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:26261183 |
| SHTN1 | NTN1 | O95631 | S | 101 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:26261183 |
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Western BlottingMass SpectrometryImmunoelectron MicroscopyFlow Cytometry | 1 | 36146834 |
Sequence, Structure & Domains
Sequences
Length
631
Mass
71,640
Sequence
MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKGVHLRPVNQTARPKTKPESSKGCESAVDELKGILGTLNKSTSSRSLKSLDPENSETELERILRRRKVTAEADSSSPTGILATSESKSMPVLGSVSSVTKTALNKKTLEAEFNSPSPPTPEPGEGPRKLEGCTSSKVTFQPPSSIGCRKKYIDGEKQAEPVVVLDPVSTHEPQTKDQVAEKDPTQHKEDEGEIQPENKEDSIENVRETDSSNC
Alternative Products
Event=Alternative splicing; Named isoforms=8; Name=1; IsoId=A0MZ66-1; Sequence=Displayed; Name=2; IsoId=A0MZ66-2; Sequence=VSP_027050, VSP_027051; Name=3; IsoId=A0MZ66-3; Sequence=VSP_027053; Name=4; IsoId=A0MZ66-4; Sequence=VSP_027052; Name=5; IsoId=A0MZ66-5; Sequence=VSP_036498; Name=6; IsoId=A0MZ66-6; Sequence=VSP_036499; Name=7; IsoId=A0MZ66-7; Sequence=VSP_036497; Name=8; IsoId=A0MZ66-8; Sequence=VSP_036498, VSP_027052
Alternative Sequence
1..412; Missing (in isoform 7); 1..60; Missing (in isoform 5 and isoform 8); 1..37; MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEK -> MPRILKQ (in isoform 6); 454..456; GTL -> ASQ (in isoform 2); 457..631; Missing (in isoform 2); 559..631; Missing (in isoform 4 and isoform 8); 623..631; VRETDSSNC -> FFPFHFGFEGVLPLAGVTLSTKARDPK (in isoform 3)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
352..369; Pro residues; 403..418; Basic and acidic residues; 456..465; Polar residues; 490..505; Polar residues; 550..561; Polar residues; 590..631; Basic and acidic residues
Coiled Coil
7..353
Domain (CC)
The N-terminus region is necessary for interaction with actin retrograde filament flow and accumulation in neuronal growth cones.
Region
343..511; Disordered; 524..566; Disordered; 579..631; Disordered
Protein Families
Shootin family
Sequence Similarities
Belongs to the shootin family.