Protein detail

SHOT1

Shootin-1 (Shootin1)

Entry name SHOT1	UniProt ID A0MZ66	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Shootin-1 (Shootin1)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000187164

Entrez Gene Symbol

SHTN1

Gene Synonym (3)

KIAA1598shootin-1shootin1

Gene Description

Shootin 1

Chromosome

Position

116881477-117126586

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain Specificastrocyte

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (12)

Page 1 of 2

Molecular Function (5)

Biological Process (3)

Reactome (3)

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence8

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SHTN1	NTN1	O95631	S	249	phosphorylation	RLIMS-P_ProtMapperSparser_ProtMapperProtMapper	ProtMapper:26261183
SHTN1	NTN1	O95631	S	101	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:26261183

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CDC42BPB IFT140 LURAP1L SHTN1 UBXN2B	A0MZ66 Q14CS0 Q8IV03 Q96RY7 Q9Y5S2	0:0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western BlottingMass SpectrometryImmunoelectron MicroscopyFlow Cytometry	1	36146834

Sequence, Structure & Domains11

Sequences

Length

631

Mass

71,640

Sequence

MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKGVHLRPVNQTARPKTKPESSKGCESAVDELKGILGTLNKSTSSRSLKSLDPENSETELERILRRRKVTAEADSSSPTGILATSESKSMPVLGSVSSVTKTALNKKTLEAEFNSPSPPTPEPGEGPRKLEGCTSSKVTFQPPSSIGCRKKYIDGEKQAEPVVVLDPVSTHEPQTKDQVAEKDPTQHKEDEGEIQPENKEDSIENVRETDSSNC

Alternative Products

Event=Alternative splicing; Named isoforms=8; Name=1; IsoId=A0MZ66-1; Sequence=Displayed; Name=2; IsoId=A0MZ66-2; Sequence=VSP_027050, VSP_027051; Name=3; IsoId=A0MZ66-3; Sequence=VSP_027053; Name=4; IsoId=A0MZ66-4; Sequence=VSP_027052; Name=5; IsoId=A0MZ66-5; Sequence=VSP_036498; Name=6; IsoId=A0MZ66-6; Sequence=VSP_036499; Name=7; IsoId=A0MZ66-7; Sequence=VSP_036497; Name=8; IsoId=A0MZ66-8; Sequence=VSP_036498, VSP_027052

Alternative Sequence

1..412; Missing (in isoform 7); 1..60; Missing (in isoform 5 and isoform 8); 1..37; MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEK -> MPRILKQ (in isoform 6); 454..456; GTL -> ASQ (in isoform 2); 457..631; Missing (in isoform 2); 559..631; Missing (in isoform 4 and isoform 8); 623..631; VRETDSSNC -> FFPFHFGFEGVLPLAGVTLSTKARDPK (in isoform 3)

Domain & Motif Annotations

Compositional Bias

352..369; Pro residues; 403..418; Basic and acidic residues; 456..465; Polar residues; 490..505; Polar residues; 550..561; Polar residues; 590..631; Basic and acidic residues

Coiled Coil

7..353

Domain (CC)

The N-terminus region is necessary for interaction with actin retrograde filament flow and accumulation in neuronal growth cones.

Region

343..511; Disordered; 524..566; Disordered; 579..631; Disordered

Protein Families

Shootin family

Sequence Similarities

Belongs to the shootin family.

Clinical Relevance4

Antibody (3)

HPA037942 HPA037943 HPA075224

Interaction Protein (3)

ENSG00000108953ENSG00000164924ENSG00000166913

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications1

PMID	Title	Abstract
37740815	Role of exosome-mediated molecules SNORD91A and SLC40A1 in M2 macrophage polarization and prognosis of ESCC.	No abstract available