Protein detail
SC5AA
Sodium/mannose cotransporter SLC5A10 (Sodium/glucose cotransporter 5) (Na(+)/glucose cotransporter 5) (Solute carrier family 5 member 10)
Protein symbol SC5AA | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 14 | Protein classification Metabolic proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Sodium/mannose cotransporter SLC5A10 (Sodium/glucose cotransporter 5) (Na(+)/glucose cotransporter 5) (Solute carrier family 5 member 10)
Protein Class
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
16..36; Helical; 73..93; Helical; 100..120; Helical; 150..170; Helical; 174..194; Helical; 201..221; Helical; 265..285; Helical; 301..321; Helical; 356..376; Helical; 410..430; Helical; 444..464; Helical; 472..492; Helical; 514..534; Helical; 576..596; Helical
Transmembrane Count
14
Ensembl
Entrez Gene Symbol
Gene Synonym
SGLT5
Gene Description
Solute carrier family 5 member 10
Chromosome
17
Position
18950345-19022595
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificEndometrial ciliated cellsSingle-Nuclei Brain SpecificoligodendrocyteBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
19 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | No | No |
| slc5 | transporter | Surfaceome | No | Yes | No | No | No |
| apc | transporter | Surfaceome | No | Yes | No | No | No |
| slc | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
596
Mass
64,342
Sequence
MAANSTSDLHTPGTQLSVADIIVITVYFALNVAVGIWSSCRASRNTVNGYFLAGRDMTWWPIGASLFASSEGSGLFIGLAGSGAAGGLAVAGFEWNATYVLLALAWVFVPIYISSEIVTLPEYIQKRYGGQRIRMYLSVLSLLLSVFTKISLDLYAGALFVHICLGWNFYLSTILTLGITALYTIAGGLAAVIYTDALQTLIMVVGAVILTIKAFDQIGGYGQLEAAYAQAIPSRTIANTTCHLPRTDAMHMFRDPHTGDLPWTGMTFGLTIMATWYWCTDQVIVQRSLSARDLNHAKAGSILASYLKMLPMGLIIMPGMISRALFPDDVGCVVPSECLRACGAEVGCSNIAYPKLVMELMPIGLRGLMIAVMLAALMSSLTSIFNSSSTLFTMDIWRRLRPRSGERELLLVGRLVIVALIGVSVAWIPVLQDSNSGQLFIYMQSVTSSLAPPVTAVFVLGVFWRRANEQGAFWGLIAGLVVGATRLVLEFLNPAPPCGEPDTRPAVLGSIHYLHFAVALFALSGAVVVAGSLLTPPPQSVQIENLTWWTLAQDVPLGTKAGDGQTPQKHAFWARVCGFNAILLMCVNIFFYAYFA
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=IF2; IsoId=A0PJK1-1; Sequence=Displayed; Name=2; Synonyms=IF3; IsoId=A0PJK1-2; Sequence=VSP_029417; Name=3; IsoId=A0PJK1-3; Sequence=VSP_029416, VSP_029417, VSP_029418, VSP_029419; Name=4; Synonyms=IF1; IsoId=A0PJK1-4; Sequence=VSP_029418; Name=5; Synonyms=IF4; IsoId=A0PJK1-5; Sequence=VSP_045061
Alternative Sequence
1..56; Missing (in isoform 3); 187..213; Missing (in isoform 2 and isoform 3); 327; P -> PGAHVYEERHQVSVSRT (in isoform 3 and isoform 4); 328..363; Missing (in isoform 5); 414; R -> RTGIPSTPPAPQSRLSFLLPETPPLERYLLGLVVMDLW (in isoform 3)
3D Structural Models
Domain & Motif Annotations
Protein Families
Sodium:solute symporter (SSF) (TC 2.A.21) family
Sequence Similarities
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Clinical Relevance
Antibody