Protein detail

PKHG3

Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3)

Entry name PKHG3	UniProt ID A1L390	EVMP confidence score 0.60
Supporting publications (n) 11	Transmembrane count	Protein classification Predicted intracellular proteins

Basic Information

Protein Names

Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000126822

Entrez Gene Symbol

PLEKHG3

Gene Synonym (2)

ARHGEF43KIAA0599

Gene Description

Pleckstrin homology and RhoGEF domain containing G3

Chromosome

Position

64704102-64750249

Supporting publications (n)

EVMP confidence score

0.60

Fluorescence & Localization

Tissue SpecificbrainCell SpecificBrain inhibitory neuronsSingle-Nuclei Brain Specificcerebellar inhibitory

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function (3)

Biological Process (3)

Reactome (7)

Mediation Categories

Receptor-signaling mediation

Relations & Evidence7

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	UniProt_location
intracellular	intracellular	OmniPath

Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PKHG3	A1L390	CDC42	P60953	Yes	Yes		SIGNOR	SIGNOR:32203420

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	DST MYO19 PLEKHG3 ZBTB20	A1L390 Q03001 Q96H55 Q9HC78	0:0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	3	37322475 36982312 38207106

Sequence, Structure & Domains

Sequences

Length

1,219

Mass

134,412

Sequence

MPVSTSLHQDGSQERPVSLTSTTSSSGSSCDSRSAMEEPSSSEAPAKNGAGSLRSRHLPNSNNNSSSWLNVKGPLSPFNSRAAAGPAHHKLSYLGRVVREIVETERMYVQDLRSIVEDYLLKIIDTPGLLKPEQVSALFGNIENIYALNSQLLRDLDSCNSDPVAVASCFVERSQEFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPDLTTYGELVLEGTFRVHRVRNERTFFLFDKTLLITKKRGDHFVYKGNIPCSSLMLIESTRDSLCFTVTHYKHSKQQYSIQAKTVEEKRNWTHHIKRLILENHHATIPQKAKEAILEMDSYYPNRYRCSPERLKKAWSSQDEVSTNVRQGRRQSEPTKHLLRQLNEKARAAGMKGKGRRESESSRSSRRPSGRSPTSTEKRMSFESISSLPEVEPDPEAGSEQEVFSAVEGPSAEETPSDTESPEVLETQLDAHQGLLGMDPPGDMVDFVAAESTEDLKALSSEEEEEMGGAAQEPESLLPPSVLDQASVIAERFVSSFSRRSSVAQEDSKSSGFGSPRLVSRSSSVLSLEGSEKGLARHGSATDSLSCQLSPEVDISVGVATEDSPSVNGMEPPSPGCPVEPDRSSCKKKESALSTRDRLLLDKIKSYYENAEHHDAGFSVRRRESLSYIPKGLVRNSISRFNSLPRPDPEPVPPVGSKRQVGSRPTSWALFELPGPSQAVKGDPPPISDAEFRPSSEIVKIWEGMESSGGSPGKGPGQGQANGFDLHEPLFILEEHELGAITEESATASPESSSPTEGRSPAHLARELKELVKELSSSTQGELVAPLHPRIVQLSHVMDSHVSERVKNKVYQLARQYSLRIKSNKPVMARPPLQWEKVAPERDGKSPTVPCLQEEAGEPLGGKGKRKPVLSLFDYEQLMAQEHSPPKPSSAGEMSPQRFFFNPSAVSQRTTSPGGRPSARSPLSPTETFSWPDVRELCSKYASRDEARRAGGGRPRGPPVNRSHSVPENMVEPPLSGRVGRCRSLSTKRGRGGGEAAQSPGPLPQSKPDGGETLYVTADLTLEDNRRVIVMEKGPLPSPTAGLEESSGQGPSSPVALLGQVQDFQQSAECQPKEEGSRDPADPSQQGRVRNLREKFQALNSVG

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A1L390-1; Sequence=Displayed; Name=2; IsoId=A1L390-2; Sequence=VSP_028533, VSP_041513; Name=3; IsoId=A1L390-3; Sequence=VSP_028534

Alternative Sequence

1..466; Missing (in isoform 2); 118..173; Missing (in isoform 3); 467..468; MK -> M (in isoform 2)

Domain & Motif Annotations

Compositional Bias

1..10; Polar residues; 18..46; Low complexity; 431..442; Polar residues; 446..463; Basic and acidic residues; 630..645; Low complexity; 696..708; Basic and acidic residues; 826..836; Gly residues; 859..873; Low complexity; 1020..1029; Polar residues; 1049..1065; Basic and acidic residues; 1187..1197; Basic and acidic residues

Domain (FT)

93..272; DH; 296..394; PH

Region

1..66; Disordered; 431..599; Disordered; 613..708; Disordered; 756..780; Disordered; 821..840; Disordered; 859..878; Disordered; 955..1133; Disordered; 1146..1207; Disordered

Clinical Relevance

Antibody (3)

HPA063455 HPA073702 HPA074734

Supporting Publications11

PMID	Title	Related sentences
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No related sentences available

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