Protein detail
SPD2B
SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains)
Entry name SPD2B | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains)
Protein Class (3)
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function (3)
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
FLJ20831KIAA1295
Gene Description
SH3 and PX domains 2B
Chromosome
5
Position
172325000-172454525
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization3
Cell SpecificRetinal horizontal cellsSecretome LocationIntracellular and membraneSecretome FunctionDevelopmental protein
Function & Pathway6
Protein Function (3)
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
- Predicted intracellular proteins
Cellular Component (4)
Molecular Function (6)
Biological Process (3)
Canonical Pathways (3)
- M17200 Sa b cell receptor complexes
- M8626 Sig bcr signaling pathway
- M141 Pid pi3kci pathway
Mediation Categories (2)
Immune mediationMetabolism mediation
Relations & Evidence14
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SH3PXD2B | SRC | P12931 | Y | 508 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:20943948SIGNOR:20943948 |
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SRC | P12931 | SPD2B | A1X283 | Yes | Yes | No | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:20943948SIGNOR:20943948ProtMapper:20943948 |
| SPD2B | A1X283 | NOXA1 | Q86UR1 | Yes | Yes | No | SIGNOR | SIGNOR:20943948 |
Protein Complex Composition (6)
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| AHSGDIS3PPP5CSH3PXD2BSTXBP3 | A1X283O00186P02765P53041Q9Y2L1 | 0:0:0:0:0 | Havugimana2012 | Havugimana2012:C_431 | ||
| NEBLSH3PXD2ASH3PXD2BWHR1ZNF764 | A1X283O76041P49842Q5TCZ1Q96H86 | 0:0:0:0:0 | hu.MAP2 | |||
| NEBLSH3PXD2BZNF764 | A1X283O76041Q96H86 | 0:0:0 | hu.MAP2 | |||
| ARPP19RABIFSH3PXD2BTRIM25 | A1X283P47224P56211Q14258 | 0:0:0:0 | hu.MAP | |||
| CBLBSH3PXD2B | A1X283Q13191 | 0:0 | hu.MAP | |||
| ENPP2PSPC1SH3PXD2B | A1X283Q13822Q8WXF1 | 0:0:0 | hu.MAP |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 30950185 |
Sequence, Structure & Domains9
Sequences
Length
911
Mass
101,579
Sequence
MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERERERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPFLSNSLGGQDDTRGKGSLGPWGTGKIGENREKAAAASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP
Domain & Motif Annotations
Compositional Bias
282..292; Pro residues; 311..337; Basic and acidic residues; 338..347; Basic residues; 486..499; Basic and acidic residues; 517..548; Basic and acidic residues; 571..586; Basic and acidic residues; 598..609; Basic and acidic residues; 618..628; Basic and acidic residues; 643..653; Pro residues; 756..766; Pro residues; 822..831; Gly residues
Domain (CC)
The PX domain is required for podosome localization because of its ability to bind phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and, to a lesser extent, phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Binds to the third intramolecular SH3 domain (By similarity).
Domain (FT)
5..129; PX; 152..211; SH3 1; 221..280; SH3 2; 368..427; SH3 3; 850..911; SH3 4
Region
275..366; Disordered; 458..834; Disordered
Protein Families
SH3PXD2 family
Sequence Similarities
Belongs to the SH3PXD2 family.
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 38576002 | Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation. | No abstract available |