Protein detail

GRD2I

Delphilin (Glutamate receptor, ionotropic, delta 2-interacting protein 1)

Entry name GRD2I	UniProt ID A4D2P6	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information6

Protein Names

Delphilin (Glutamate receptor, ionotropic, delta 2-interacting protein 1)

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000215045

Entrez Gene Symbol

GRID2IP

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Cell SpecificAdrenal cortex cellsSecretome LocationSecreted to bloodSecretome FunctionReceptor

Function & Pathway3

Protein Function

Predicted intracellular proteins

Cellular Component (4)

Mediation Categories (2)

Metabolism mediationReceptor-signaling mediation

Relations & Evidence4

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
GRD2I	A4D2P6	GRID2	O43424	Yes	Yes	No	Lit-BM-17SIGNOR	SIGNOR:11826110 Lit-BM-17:11826110

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Western blottingFACS	5	16708399 17868797 21044087 37960298 37993261

Sequence, Structure & Domains6

Sequences

Length

1,211

Mass

132,276

Sequence

MATTATPATNQGWPEDFGFRLGGSGPCFVLEVAKGSSAHAGGLRPGDQILEVEGLAVGGLSRERLVRLARRCPRVPPSLGVLPAPDGGPGPGSGPAAPTTVLRAPRCGRGLALGRELLRLAGRKRPDAVHRERRRKAQEFSRKVDEILGDQPTAKEQVFAALKQFAAEQRVDDLVWTLTLALPREACGPLLDNLRIFIPKKHRARFDEVVSQGLLGKLCRARRAQGAQRLRRSRSEERPERLLVSTRASAPPRRPDEPPPRRASLLVGGLAGPGGARRTVRVYKGNKSFGFTLRGHGPVWIESVLPGSPADNAALKSGDRILFLNGLDMRNCSHDKVVSMLQGSGAMPTLVVEEGLVPFASDSDSLDSPNPSSALTSLQWVAEILPSSIRVQGRTFSQQLEHLLTPPERYGVCRALESFFQHRNIDTLIVDVYPVLDTPAKQVLWQFIYQLLTYEEQELCQEKIACFLGYTAMTAEPEPELDLESEPTPEPQPRSSLRASSMCRRSLRSQGLEAGLSCGPSECPEMPLPLIPGERQAGDGTSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVSWPSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSPPSPDPTRPPSRRKLFTFSHPVRSRDTDRFLDVLSEQLGPRVTIVDDFLTPENDYEEMSFHDDQGSFVTNERSSASDCISSSEEGSSLTYSSISDHIPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLPPPVPCAPPMLSRGLGHRRSETSHMSVKRLRWEQVENSEGTIWGQLGEDSDYDKLSDMVKYLDLELHFGTQKPAKPVPGPEPFRKKEVVEILSHKKAYNTSILLAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLPTVPLAAKVNQRALTSDLADLHGTISEIQDACQSISPSSEDKFAMVMSSFLETAQPALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERALSDLQAGEGLRSSGMVSPLAW

Domain & Motif Annotations

Compositional Bias

242..251; Low complexity; 478..487; Acidic residues; 587..599; Polar residues; 618..639; Low complexity; 640..661; Pro residues; 725..746; Low complexity; 749..763; Pro residues; 770..781; Low complexity

Domain (FT)

3..84; PDZ 1; 279..356; PDZ 2; 820..1211; FH2

Region

226..269; Disordered; 478..502; Disordered; 525..549; Disordered; 568..600; Disordered; 618..672; Disordered; 718..783; Disordered

Supporting Publications2

PMID	Title	Abstract
32002171	Activated human astrocyte-derived extracellular vesicles modulate neuronal uptake, differentiation and firing.	No abstract available
39363010	Proteomic analysis of plasma-derived extracellular vesicles: pre- and postprandial comparisons.	No abstract available