Protein detail

SH321

SH3 domain-containing protein 21

Entry name SH321	UniProt ID A4FU49	EVMP confidence score 0.38
Supporting publications (n) 3	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

SH3 domain-containing protein 21

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000214193

Entrez Gene Symbol

SH3D21

Gene Synonym (2)

C1orf113FLJ22938

Gene Description

SH3 domain containing 21

Chromosome

Position

36306368-36329340

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Tissue Specificbone marrowCell SpecificNeutrophilsSingle-Nuclei Brain Specificmammillary bodyBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes

Function & Pathway4

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Canonical Pathways (3)

M3468 Naba ecm regulators
M5885 Naba matrisome associated
M5889 Naba matrisome

Mediation Categories

Fusion and delivery mediation

Relations & Evidence3

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains9

Sequences

Length

640

Mass

70,519

Sequence

MVQSELQLQPRAGGRAEAASWGDRGNDKGGLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPPPPIKKLVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQKLTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVKRTPMPDKTATPERPPAPENAPSSKKIPAPDKVPSPEKTLTLGDKASIPGNSTSGKIPAPDKVPTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKEDPSSQEEAHTPEAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPASRPALEKPHPHEEATTLPEEAPSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELPPKEEVAPKEEVPPIERAFAQKTRPIKPPPDSQETLALPSLVPQNYTENKNEGVDVTSLRGEVESLRRALELMEVQLERKLTDIWEELKSEKEQRRRLEVQVMQGTQKSQTPRVIHTQTQTY

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=A4FU49-1; Sequence=Displayed; Name=2; IsoId=A4FU49-3; Sequence=VSP_040924; Name=3; IsoId=A4FU49-4; Sequence=VSP_040923, VSP_040925, VSP_040926; Name=4; IsoId=A4FU49-5; Sequence=VSP_040927, VSP_040928; Name=5; IsoId=A4FU49-6; Sequence=VSP_045936

Alternative Sequence

1..96; MVQSELQLQPRAGGRAEAASWGDRGNDKGGLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLS -> MIKEIEDGWWLGKRNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPP (in isoform 3); 1..30; MVQSELQLQPRAGGRAEAASWGDRGNDKGG -> MIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPPS (in isoform 2); 1..30; MVQSELQLQPRAGGRAEAASWGDRGNDKGG -> MEVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPPS (in isoform 5); 173..179; TSRTPSR -> RKSTAAR (in isoform 3); 180..640; Missing (in isoform 3); 191..232; PNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVKAP -> GRAQQPGKGPLCEENPHAGQDCHPREAPSSRERPQLQEDPGS (in isoform 4); 233..640; Missing (in isoform 4)

Domain & Motif Annotations

Compositional Bias

177..186; Basic and acidic residues; 210..220; Polar residues; 401..416; Basic and acidic residues; 459..469; Basic and acidic residues; 494..532; Basic and acidic residues; 621..640; Polar residues

Coiled Coil

572..626

Domain (FT)

65..126; SH3

Region

1..60; Disordered; 133..361; Disordered; 401..551; Disordered; 618..640; Disordered

Clinical Relevance1

Antibody (3)

HPA042212 HPA042456 HPA066168

Supporting Publications3

PMID	Title	Abstract
36406491	Automated Proteomics Sample Preparation of Phosphatidylserine-Positive Extracellular Vesicles from Human Body Fluids.	No abstract available
38225453	Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available