Protein detail

SH321

SH3 domain-containing protein 21

Entry name
SH321
UniProt ID
EVMP score
0.38
Frequency
3
Transmembrane count
Protein classification
Predicted intracellular proteins
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
SH3 domain-containing protein 21
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Entrez Gene Symbol
Gene Synonym
C1orf113FLJ22938
Gene Description
SH3 domain containing 21
Chromosome
1
Position
36306368-36329340
Frequency
3
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificNeutrophilsSingle-Nuclei Brain Specificmammillary bodyBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
Predicted intracellular proteins
Canonical Pathways
  • M3468 Naba ecm regulators
  • M5885 Naba matrisome associated
  • M5889 Naba matrisome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

2 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo

Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Mass spectrometry0
Sequence, Structure & Domains

Sequences

Length
640
Mass
70,519
Sequence
MVQSELQLQPRAGGRAEAASWGDRGNDKGGLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPPPPIKKLVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQKLTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVKRTPMPDKTATPERPPAPENAPSSKKIPAPDKVPSPEKTLTLGDKASIPGNSTSGKIPAPDKVPTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKEDPSSQEEAHTPEAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPASRPALEKPHPHEEATTLPEEAPSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELPPKEEVAPKEEVPPIERAFAQKTRPIKPPPDSQETLALPSLVPQNYTENKNEGVDVTSLRGEVESLRRALELMEVQLERKLTDIWEELKSEKEQRRRLEVQVMQGTQKSQTPRVIHTQTQTY
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=A4FU49-1; Sequence=Displayed; Name=2; IsoId=A4FU49-3; Sequence=VSP_040924; Name=3; IsoId=A4FU49-4; Sequence=VSP_040923, VSP_040925, VSP_040926; Name=4; IsoId=A4FU49-5; Sequence=VSP_040927, VSP_040928; Name=5; IsoId=A4FU49-6; Sequence=VSP_045936
Alternative Sequence
1..96; MVQSELQLQPRAGGRAEAASWGDRGNDKGGLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLS -> MIKEIEDGWWLGKRNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPP (in isoform 3); 1..30; MVQSELQLQPRAGGRAEAASWGDRGNDKGG -> MIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPPS (in isoform 2); 1..30; MVQSELQLQPRAGGRAEAASWGDRGNDKGG -> MEVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPPS (in isoform 5); 173..179; TSRTPSR -> RKSTAAR (in isoform 3); 180..640; Missing (in isoform 3); 191..232; PNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVKAP -> GRAQQPGKGPLCEENPHAGQDCHPREAPSSRERPQLQEDPGS (in isoform 4); 233..640; Missing (in isoform 4)

3D Structural Models

Domain & Motif Annotations

Compositional Bias
177..186; Basic and acidic residues; 210..220; Polar residues; 401..416; Basic and acidic residues; 459..469; Basic and acidic residues; 494..532; Basic and acidic residues; 621..640; Polar residues
Coiled Coil
572..626
Domain (FT)
65..126; SH3
Region
1..60; Disordered; 133..361; Disordered; 401..551; Disordered; 618..640; Disordered
Clinical Relevance