Protein detail

TPC13

Trafficking protein particle complex subunit 13

Entry name TPC13	UniProt ID A5PLN9	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Trafficking protein particle complex subunit 13

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000113597

Entrez Gene Symbol

TRAPPC13

Gene Synonym (3)

C5orf44FLJ13611MGC48585

Gene Description

Trafficking protein particle complex subunit 13

Chromosome

Position

65625004-65666233

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Tissue Specificadipose tissueCell SpecificFibro-adipogenic progenitorsSingle-Nuclei Brain Specificvascular associated smooth muscle cellSecretome LocationSecreted to extracellular matrixSecretome FunctionCell adhesion

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (4)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Reactome (4)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence12

Ligand-Receptor Signaling (3)

3 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (8)

8 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
TRAPP II complexTRAPPC2 variant	TRAPPC1 TRAPPC10 TRAPPC13 TRAPPC2 TRAPPC2L TRAPPC3 TRAPPC4 TRAPPC5 TRAPPC6B TRAPPC9	A5PLN9 O43617 P0DI81 P48553 Q86SZ2 Q8IUR0 Q96Q05 Q9UL33 Q9Y296 Q9Y5R8	1:1:1:1:1:1:1:1:1:1	ComplexPortal	PDB:2CFHPDB:3KXC	14755292 24917561 27066478
TRAPP II complexTRAPPC2B variant	TRAPPC1 TRAPPC10 TRAPPC13 TRAPPC2B TRAPPC2L TRAPPC3 TRAPPC4 TRAPPC5 TRAPPC6B TRAPPC9	A5PLN9 O43617 P0DI82 P48553 Q86SZ2 Q8IUR0 Q96Q05 Q9UL33 Q9Y296 Q9Y5R8	1:1:1:1:1:1:1:1:1:1	ComplexPortal	PDB:2CFHPDB:3KXC	14755292 24917561 27066478
	BCL2L14 TRAPPC1 TRAPPC10 TRAPPC11 TRAPPC12 TRAPPC13 TRAPPC14 TRAPPC2B TRAPPC2L TRAPPC3 TRAPPC4 TRAPPC5 TRAPPC6A TRAPPC6B TRAPPC8 TRAPPC9	A5PLN9 O43617 O75865 P0DI82 P48553 Q7Z392 Q86SZ2 Q8IUR0 Q8WVR3 Q8WVT3 Q96Q05 Q9BZR8 Q9UL33 Q9Y296 Q9Y2L5 Q9Y5R8	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
	TRAPPC1 TRAPPC13 TRAPPC14 TRAPPC3 TRAPPC4 TRAPPC5 TRAPPC6B	A5PLN9 O43617 Q86SZ2 Q8IUR0 Q8WVR3 Q9Y296 Q9Y5R8	0:0:0:0:0:0:0	hu.MAP2
	CTR9 IWS1 LEO1 PAF1 SKIC8 TRAPPC13	A5PLN9 Q6PD62 Q8N7H5 Q8WVC0 Q96ST2 Q9GZS3	0:0:0:0:0:0	hu.MAP
	CTR9 IWS1 LEO1 SKIC8 TRAPPC13	A5PLN9 Q6PD62 Q8WVC0 Q96ST2 Q9GZS3	0:0:0:0:0	hu.MAP
	NIN SKIC8 TRAPPC13	A5PLN9 Q8N4C6 Q9GZS3	0:0:0	hu.MAP
	SKIC8 TRAPPC13	A5PLN9 Q9GZS3	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometryWestern blotting	24	30950185 39558134 32284825 35611462 32489530 32944193 36612172 39766158 29436780 31918306 37786918 38168906 39573935 39409015 34817906 28986585 27894104 31941606 38321535 40089067 32089743 37205098 34186243 30646616

Sequence, Structure & Domains7

Sequences

Length

417

Mass

46,524

Sequence

MEVNPPKQEHLLALKVMRLTKPTLFTNIPVTCEEKDLPGDLFNQLMRDDPSTVNGAEVLMLGEMLTLPQNFGNIFLGETFSSYISVHNDSNQVVKDILVKADLQTSSQRLNLSASNAAVAELKPDCCIDDVIHHEVKEIGTHILVCAVSYTTQAGEKMYFRKFFKFQVLKPLDVKTKFYNAESDLSSVTDEVFLEAQIQNMTTSPMFMEKVSLEPSIMYNVTELNSVSQAGECVSTFGSRAYLQPMDTRQYLYCLKPKNEFAEKAGIIKGVTVIGKLDIVWKTNLGERGRLQTSQLQRMAPGYGDVRLSLEAIPDTVNLEEPFHITCKITNCSERTMDLVLEMCNTNSIHWCGISGRQLGKLHPSSSLCLALTLLSSVQGLQSISGLRLTDTFLKRTYEYDDIAQVCVVSSAIKVES

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=A5PLN9-1; Sequence=Displayed; Name=2; IsoId=A5PLN9-2; Sequence=VSP_038356; Name=3; IsoId=A5PLN9-4; Sequence=VSP_038356, VSP_038359; Name=4; IsoId=A5PLN9-5; Sequence=VSP_038359; Name=5; IsoId=A5PLN9-7; Sequence=VSP_038356, VSP_038357, VSP_038358

Alternative Sequence

183..188; Missing (in isoform 2, isoform 3 and isoform 5); 300..315; APGYGDVRLSLEAIPD -> VSLEKTSLGFWCVKDR (in isoform 5); 316..417; Missing (in isoform 5); 332; C -> CS (in isoform 3 and isoform 4)

Domain & Motif Annotations

Protein Families

TRAPPC13 family

Sequence Similarities

Belongs to the TRAPPC13 family.

Clinical Relevance4

Antibody

HPA037777

Interaction Protein (3)

ENSG00000167515ENSG00000170043ENSG00000196459

Interaction Count

Interaction Dataset (2)

intact_biogridbiogrid_opencell

Supporting Publications1

PMID	Title	Abstract
38343172	Analysis of secreted small extracellular vesicles from activated human microglial cell lines reveals distinct pro- and anti-inflammatory proteomic profiles.	No abstract available