Protein detail

RCCD1

RCC1 domain-containing protein 1

Entry name RCCD1	UniProt ID A6NED2	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

RCC1 domain-containing protein 1

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000166965

Entrez Gene Symbol

RCCD1

Gene Synonym

MGC14386

Gene Description

RCC1 domain containing 1

Chromosome

Position

90954881-90963125

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (3)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Reactome (3)

Mediation Categories

Metabolism mediation

Relations & Evidence8

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (3)

3 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
KDM8-RCCD1 complex	KDM8 RCCD1	A6NED2 Q8N371	1:1	CORUMPDB	PDB:6f4tCORUM:7377PDB:6f4sPDB:6f4r	24981860
	MTREX RCCD1 TENT4A TENT4B UHMK1 ZCCHC7	A6NED2 P42285 Q5XG87 Q8N3Z6 Q8NDF8 Q8TAS1	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7966
	KCTD9 KDM8 RCCD1	A6NED2 Q7L273 Q8N371	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Western blotting	2	38731868 37922300

Sequence, Structure & Domains6

Sequences

Length

376

Mass

40,079

Sequence

MAEERPGAWFGFGFCGFGQELGSGRGRQVHSPSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKGKS

3D Structural Models

3D Structure

X-ray crystallography (3)

Domain & Motif Annotations

Repeat

6..56; RCC1 1; 176..227; RCC1 2; 229..317; RCC1 3; 318..371; RCC1 4

Region

1..169; Interaction with KDM8

Clinical Relevance4

Antibody (2)

HPA039683 HPA040776

Interaction Protein

ENSG00000155666

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available