Protein detail

TCAF2

TRPM8 channel-associated factor 2 (TRP channel-associated factor 2)

Entry name TCAF2	UniProt ID A6NFQ2	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

TRPM8 channel-associated factor 2 (TRP channel-associated factor 2)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000170379

Entrez Gene Symbol

TCAF2

Gene Synonym (4)

FAM115CFAM139AFLJ40722GATD9B

Gene Description

TRPM8 channel associated factor 2

Chromosome

Position

143620952-143730410

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization6

Tissue Specificadrenal glandBrain Regional Specificcerebral cortexCell SpecificAdrenal medulla cellsSingle-Nuclei Brain SpecificfibroblastBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway4

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function

GO:0044325 transmembrane transporter binding

Mediation Categories

Fusion and delivery mediation

Relations & Evidence7

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	MADCAM1 STXBP3 TCAF2 TMEM97	A6NFQ2 O00186 Q13477 Q5BJF2	0:0:0:0	hu.MAP2
	MADCAM1 TCAF2 TMEM97	A6NFQ2 Q13477 Q5BJF2	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western BlottingMass SpectrometryImmunoelectron MicroscopyFlow Cytometry	1	36146834

Sequence, Structure & Domains8

Sequences

Length

919

Mass

100,906

Sequence

MATIAAAAFEALMDGVTCWDVPRGPIPSELLLIGEAAFPVMVNDKGQVLIAASSYGRGRLVVVSHEGYLSHTGLAPFLLNAVSWLCPCPGAPVGVHPSLAPLVNILQDAGLEAQVKPEPGEPLGVYCINAYNDTLTATLIQFVKHGGGLLIGGQAWYWASQHGPDKVLSRFPGNKVTSVAGVYFTDTYGDRDRFKVSKKVPKIPLHVRYGEDVRQDQQQLLEGISELDIRTGGVPSQLLVHGALAFPLGLDASLNCFLAAAHYGRGRVVLAAHECLLCAPKMGPFLLNAVRWLARGQTGKVGVNTNLKDLCPLLSEHGLQCSLEPHLNSDLCVYCCKAYSDKEAKQLQEFVAEGGGLLIGGQAWWWASQNPGHCPLAGFPGNIILNCFGLSILPQTLKAGCFPVPTPEMRSYHFRKALSQFQAILNHENGNLEKSCLAKLRVDGAAFLQIPAEGVPAYISLHRLLRKMLRGSGLPAVSRENPVASDSYEAAVLSLATGLAHSGTDCSQLAQGLGTWTCSSSLYPSKHPITVEINGINPGNNDCWVSTGLYLLEGQNAEVSLSEAAASAGLRVQIGCHTDDLTKARKLSRAPVVTHQCWMDRTERSVSCLWGGLLYVIVPKGSQLGPVPVTIRGAVPAPYYKLGKTSLEEWKRQMQENLAPWGELATDNIILTVPTTNLQALKDPEPVLRLWDEMMQAVARLAAEPFPFRRPERIVADVQISAGWMHSGYPIMCHLESVKEIINEMDMRSRGVWGPIHELGHNQQRHGWEFPPHTTEATCNLWSVYVHETVLGIPRAQAHEALSPPERERRIKAHLGKGAPLCDWNVWTALETYLQLQEAFGWEPFTQLFAEYQTLSHLPKDNTGRMNLWVKKFSEKVKKNLVPFFEAWGWPIQKEVADSLASLPEWQENPMQVYLRARK

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A6NFQ2-1; Sequence=Displayed; Name=2; IsoId=A6NFQ2-2; Sequence=VSP_031635; Name=3; IsoId=A6NFQ2-3; Sequence=VSP_042050, VSP_042051

Alternative Sequence

1..207; MATIAAAAFEALMDGVTCWDVPRGPIPSELLLIGEAAFPVMVNDKGQVLIAASSYGRGRLVVVSHEGYLSHTGLAPFLLNAVSWLCPCPGAPVGVHPSLAPLVNILQDAGLEAQVKPEPGEPLGVYCINAYNDTLTATLIQFVKHGGGLLIGGQAWYWASQHGPDKVLSRFPGNKVTSVAGVYFTDTYGDRDRFKVSKKVPKIPLHV -> MKIFQKEFKFILKKCTPIQKYREENGNSSSSPHHQLQSHASGP (in isoform 3); 538; P -> PESHSVIQVGMQWRDLSSCNLHLLGLSNSSLSASCVAGTTGTRHHAWLIFVFLVEREFHRK (in isoform 3); 836..919; LQEAFGWEPFTQLFAEYQTLSHLPKDNTGRMNLWVKKFSEKVKKNLVPFFEAWGWPIQKEVADSLASLPEWQENPMQVYLRARK -> VLSRNSGRRG (in isoform 2)

Domain & Motif Annotations

Domain (FT)

542..841; Peptidase M60

Protein Families

TCAF family

Sequence Similarities

Belongs to the TCAF family.

Clinical Relevance1

Antibody (2)

HPA038756 HPA038758

Supporting Publications1

PMID	Title	Abstract
40689422	Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles.	No abstract available