Protein detail

CCD69

Coiled-coil domain-containing protein 69

Entry name CCD69	UniProt ID A6NI79	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Coiled-coil domain-containing protein 69

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000198624

Entrez Gene Symbol

CCDC69

Gene Synonym (2)

DKFZP434C171FLJ13705

Gene Description

Coiled-coil domain containing 69

Chromosome

Position

151181052-151224093

Supporting publications (n)

EVMP confidence score

0.38

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (4)

Molecular Function

GO:0008017 microtubule binding

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence7

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CCDC69 NAA10 RMI1 RMI2 TOP3A	A6NI79 P41227 Q13472 Q96E14 Q9H9A7	0:0:0:0:0	hu.MAP2
	CCDC69 RMI1 RMI2 TOP3A	A6NI79 Q13472 Q96E14 Q9H9A7	0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	6	40189497 38113368 33592500 32560723 36146834 38207106

Sequence, Structure & Domains8

Sequences

Length

296

Mass

34,796

Sequence

MGCRHSRLSSCKPPKKKRQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEELLYRVLGANASPAFPLAPVTPTEVSFLAT

Domain & Motif Annotations

Compositional Bias

1..18; Basic residues; 19..33; Basic and acidic residues

Coiled Coil

48..272

Region

1..41; Disordered

Protein Families

CCDC69 family

Sequence Similarities

Belongs to the CCDC69 family.

Clinical Relevance1

Antibody (2)

HPA043648 HPA052896

Supporting Publications2

PMID	Title	Abstract
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available
40829696	Mining the plasma proteome: Evaluation of enrichment methods for depth and reproducibility.	No abstract available