Protein detail

LRIQ3

Leucine-rich repeat and IQ domain-containing protein 3 (Leucine-rich repeat-containing protein 44)

Entry name LRIQ3	UniProt ID A6PVS8	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Leucine-rich repeat and IQ domain-containing protein 3 (Leucine-rich repeat-containing protein 44)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000162620

Entrez Gene Symbol

LRRIQ3

Gene Synonym (2)

LRRC44MGC22773

Gene Description

Leucine rich repeats and IQ motif containing 3

Chromosome

Position

74026015-74198187

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Tissue SpecificliverCell SpecificHepatocytesSingle-Nuclei Brain Specificependymal cell

Function & Pathway4

Protein Function

Predicted intracellular proteins

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence4

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	LRRIQ3 R3HCC1L	A6PVS8 Q7Z5L2	0:0	hu.MAPhu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationImmunoaffinity Capture	Western blottingMass spectrometry	1	36189227

Sequence, Structure & Domains8

Sequences

Length

624

Mass

73,675

Sequence

MFHGTVTEELTSHEEWSHYNENIREGQKDFVFVKFNGLHLKSMENLQSCISLRVCIFSNNFITDIHPLQSCIKLIKLDLHGNQIKSLPNTKFWNGLKNLKLLYLHDNGFAKLKNICVLSACPTLIALTMFDCPVSLKKGYRHVLVNSIWPLKALDHHVISDEEIIQNWHLPERFKACNHRLFFNFCPALRKGTTYEEEINNIKHITSKINAILAHNSPVLIVQRWIRGFLVRKNLSPVFFHKKKQQEKIIRGYEAKWIYITKGYEDKLLKDLFFKPETNIKGKLAYWKHNIYYPVDLKNSSEHRKHVSSILCELKPKDLGMKSKTSRHLIQKGQESEDEIVDEKLDTSFRISVFKLPIYTSGSLKNNAVLREKKQHFFPAYPQPIYTTHPKPIIKKDIRLERSMKEFFAPQRAGMKLRTFSDIDKYYTEQKKQEYHKEKVRVVAMAQVARERVRVAVNEHLNQKKYATQKLIEENKETIQNSLRQVWQNRFNYLEKARERKALFLKEKSQKASERLLVQNLNNERTLLTRGLLKIDRLEKNEAVLKEKSLIVKQKLKAEKYRKNLLKEMKKVRSQEIYKRHCEEKFVMDMIAFEKACERLQDAKTKVAIVKTNLDFKVPNGLIK

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A6PVS8-1; Sequence=Displayed; Name=2; IsoId=A6PVS8-2; Sequence=VSP_029410, VSP_029411; Name=3; IsoId=A6PVS8-3; Sequence=VSP_029408, VSP_029409

Alternative Sequence

192..199; GTTYEEEI -> EKMKHSEV (in isoform 3); 200..624; Missing (in isoform 3); 290..299; NIYYPVDLKN -> DKKKLWVNFH (in isoform 2); 300..624; Missing (in isoform 2)

Domain & Motif Annotations

Repeat

51..72; LRR 1; 73..94; LRR 2; 98..119; LRR 3

Coiled Coil

553..614

Domain (FT)

132..179; LRRCT; 215..244; IQ

Clinical Relevance1

Antibody

HPA030799

Supporting Publications1

PMID	Title	Abstract
32810692	Exosomal Transfer of LCP1 Promotes Osteosarcoma Cell Tumorigenesis and Metastasis by Activating the JAK2/STAT3 Signaling Pathway.	When coculturing OS cells with bone marrow-derived mesenchymal stem cells (BMSCs) in vitro, we validated that oncogenic LCP1 in OS was transferred from BMSCs via exosomes.