Protein detail

ZSWM8

Zinc finger SWIM domain-containing protein 8

Protein symbol ZSWM8	UniProt ID A7E2V4	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification Predicted intracellular proteins

Basic Information

Protein Names

Zinc finger SWIM domain-containing protein 8

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000214655

Entrez Gene Symbol

ZSWIM8

Gene Synonym

4832404P21RikKIAA0913

Gene Description

Zinc finger SWIM-type containing 8

Chromosome

Position

73785606-73801797

Frequency

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificLactotrophs

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Reactome

Canonical Pathways

M161 Pid ifng pathway
M288 Pid hes hey pathway

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

8 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
MRPL4 MTERF3 PTCD1 TRUB2 ZSWIM8	A7E2V4 O75127 O95900 Q96E29 Q9BYD3	0:0:0:0:0	hu.MAP2
ATN1 CSE1L HNRNPL PRRC2B ZSWIM8	A7E2V4 P14866 P54259 P55060 Q5JSZ5	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4150
DCLRE1C PYHIN1 TRIM26 ZSWIM8	A7E2V4 Q12899 Q6K0P9 Q96SD1	0:0:0:0	hu.MAP2
DCLRE1C PYHIN1 SPINK5 TRIM26 ZSWIM8	A7E2V4 Q12899 Q6K0P9 Q96SD1 Q9NQ38	0:0:0:0:0	hu.MAP2
ANKRD52 DCLRE1C PRKAG2 SPATA20 TRIM26 ZSWIM8	A7E2V4 Q12899 Q8NB46 Q8TB22 Q96SD1 Q9UGJ0	0:0:0:0:0:0	hu.MAP
DCLRE1C PRKAG2 TRIM26 ZSWIM8	A7E2V4 Q12899 Q96SD1 Q9UGJ0	0:0:0:0	hu.MAP
ANKRD52 DCLRE1C ZSWIM8	A7E2V4 Q8NB46 Q96SD1	0:0:0	hu.MAP
ANKRD52 DCLRE1C PRKAG2 ZSWIM8	A7E2V4 Q8NB46 Q96SD1 Q9UGJ0	0:0:0:0	hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyPolymer Precipitation	Mass spectrometry	8	31196968 32489530 37786918 34817906 28986585 32782317 27894104 38321535

Sequence, Structure & Domains

Sequences

Length

1,837

Mass

197,297

Sequence

MELMFAEWEDGERFSFEDSDRFEEDSLCSFISEAESLCQNWRGWRKQSAGPNSPTGGGGGGGSGGTRMRDGLVIPLVELSAKQVAFHIPFEVVEKVYPPVPEQLQLRIAFWSFPENEEDIRLYSCLANGSADEFQRGDQLFRMRAVKDPLQIGFHLSATVVPPQMVPPKGAYNVAVMFDRCRVTSCSCTCGAGAKWCTHVVALCLFRIHNASAVCLRAPVSESLSRLQRDQLQKFAQYLISELPQQILPTAQRLLDELLSSQSTAINTVCGAPDPTAGPSASDQSTWYLDESTLTDNIKKTLHKFCGPSPVVFSDVNSMYLSSTEPPAAAEWACLLRPLRGREPEGVWNLLSIVREMFKRRDSNAAPLLEILTDQCLTYEQITGWWYSVRTSASHSSASGHTGRSNGQSEVAAHACASMCDEMVTLWRLAVLDPALSPQRRRELCTQLRQWQLKVIENVKRGQHKKTLERLFPGFRPAVEACYFNWEEAYPLPGVTYSGTDRKLALCWARALPSRPGASRSGGLEESRDRPRPLPTEPAVRPKEPGTKRKGLGEGVPSSQRGPRRLSAEGGDKALHKMGPGGGKAKALGGAGSGSKGSAGGGSKRRLSSEDSSLEPDLAEMSLDDSSLALGAEASTFGGFPESPPPCPLHGGSRGPSTFLPEPPDTYEEDGGVYFSEGPEPPTASVGPPGLLPGDVCTQDDLPSTDESGNGLPKTKEAAPAVGEEDDDYQAYYLNAQDGAGGEEEKAEGGAGEEHDLFAGLKPLEQESRMEVLFACAEALHAHGYSSEASRLTVELAQDLLANPPDLKVEPPPAKGKKNKVSTSRQTWVATNTLSKAAFLLTVLSERPEHHNLAFRVGMFALELQRPPASTKALEVKLAYQESEVAALLKKIPLGPSEMSTMRCRAEELREGTLCDYRPVLPLMLASFIFDVLCAPGSRPPSRNWNSETPGDEELGFEAAVAALGMKTTVSEAEHPLLCEGTRREKGDLALALMITYKDDQAKLKKILDKLLDRESQTHKPQTLSSFYSSSRPTTASQRSPSKHGGPSAPGALQPLTSGSAGPAQPGSVAGAGPGPTEGFTEKNVPESSPHSPCEGLPSEAALTPRPEGKVPSRLALGSRGGYNGRGWGSPGRPKKKHTGMASIDSSAPETTSDSSPTLSRRPLRGGWAPTSWGRGQDSDSISSSSSDSLGSSSSSGSRRASASGGARAKTVEVGRYKGRRPESHAPHVPNQPSEAAAHFYFELAKTVLIKAGGNSSTSIFTHPSSSGGHQGPHRNLHLCAFEIGLYALGLHNFVSPNWLSRTYSSHVSWITGQAMEIGSAALTILVECWDGHLTPPEVASLADRASRARDSNMVRAAAELALSCLPHAHALNPNEIQRALVQCKEQDNLMLEKACMAVEEAAKGGGVYPEVLFEVAHQWFWLYEQTAGGSSTAREGATSCSASGIRAGGEAGRGMPEGRGGPGTEPVTVAAAAVTAAATVVPVISVGSSLYPGPGLGHGHSPGLHPYTALQPHLPCSPQYLTHPAHPAHPMPHMPRPAVFPVPSSAYPQGVHPAFLGAQYPYSVTPPSLAATAVSFPVPSMAPITVHPYHTEPGLPLPTSVACELWGQGTVSSVHPASTFPAIQGASLPALTTQPSPLVSGGFPPPEEETHSQPVNPHSLHHLHAAYRVGMLALEMLGRRAHNDHPNNFSRSPPYTDDVKWLLGLAAKLGVNYVHQFCVGAAKGVLSPFVLQEIVMETLQRLSPAHAHNHLRAPAFHQLVQRCQQAYMQYIHHRLIHLTPADYDDFVNAIRSARSAFCLTPMGMMQFNDILQNLKRSKQTKELWQRVSLEMATFSP

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=A7E2V4-1; Sequence=Displayed; Name=2; IsoId=A7E2V4-2; Sequence=VSP_029590, VSP_029591; Name=3; IsoId=A7E2V4-3; Sequence=VSP_029586, VSP_029587, VSP_029590; Name=4; IsoId=A7E2V4-4; Sequence=VSP_029586; Name=5; IsoId=A7E2V4-5; Sequence=VSP_029590

Alternative Sequence

936; P -> PVVSPT (in isoform 3 and isoform 4); 1006; K -> KVTASVFQ (in isoform 3); 1604..1612; CELWGQGTV -> L (in isoform 2, isoform 3 and isoform 5); 1712..1837; VNYVHQFCVGAAKGVLSPFVLQEIVMETLQRLSPAHAHNHLRAPAFHQLVQRCQQAYMQYIHHRLIHLTPADYDDFVNAIRSARSAFCLTPMGMMQFNDILQNLKRSKQTKELWQRVSLEMATFSP -> DRHGDAAAAESRSCPQPPACPGLPPTGAALPAGIHAVHPPPLDSPDSCGLRRLCECDPECPQRLLPDAHGHDAVQRHPTEPQAQQTDQGAVAAGLTRDGHLLPLSLSPLGSYTGTQACGYGGPSHRGSETWLDRSSSLSSLVAQTDSCSWAIAWGQDVSHPRSLGLGETALSGRGRWVASGIYLAFINI (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

55..65; Gly residues; 523..532; Basic and acidic residues; 566..575; Basic and acidic residues; 579..602; Gly residues; 1019..1040; Polar residues; 1119..1130; Gly residues; 1144..1159; Polar residues; 1174..1209; Low complexity; 1210..1226; Basic and acidic residues; 1447..1464; Gly residues

Zinc Finger

172..208; SWIM-type

Region

45..65; Disordered; 514..727; Disordered; 803..823; Disordered; 1016..1232; Disordered; 1442..1464; Disordered; 1635..1656; Disordered

Protein Families

ZSWIM8 family

Sequence Similarities

Belongs to the ZSWIM8 family.

Clinical Relevance

Antibody

HPA041244