Protein detail

ZSWM8

Zinc finger SWIM domain-containing protein 8

Entry name ZSWM8	UniProt ID A7E2V4	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Zinc finger SWIM domain-containing protein 8

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000214655

Entrez Gene Symbol

ZSWIM8

Gene Synonym (2)

4832404P21RikKIAA0913

Gene Description

Zinc finger SWIM-type containing 8

Chromosome

Position

73785606-73801797

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Cell SpecificLactotrophs

Function & Pathway7

Protein Function

Predicted intracellular proteins

Cellular Component (3)

Molecular Function (2)

Biological Process (3)

Reactome (3)

Canonical Pathways (2)

M161 Pid ifng pathway
M288 Pid hes hey pathway

Mediation Categories

Other mediation

Relations & Evidence13

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (8)

8 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
MRPL4 MTERF3 PTCD1 TRUB2 ZSWIM8	A7E2V4 O75127 O95900 Q96E29 Q9BYD3	0:0:0:0:0	hu.MAP2
ATN1 CSE1L HNRNPL PRRC2B ZSWIM8	A7E2V4 P14866 P54259 P55060 Q5JSZ5	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4150
DCLRE1C PYHIN1 TRIM26 ZSWIM8	A7E2V4 Q12899 Q6K0P9 Q96SD1	0:0:0:0	hu.MAP2
DCLRE1C PYHIN1 SPINK5 TRIM26 ZSWIM8	A7E2V4 Q12899 Q6K0P9 Q96SD1 Q9NQ38	0:0:0:0:0	hu.MAP2
ANKRD52 DCLRE1C PRKAG2 SPATA20 TRIM26 ZSWIM8	A7E2V4 Q12899 Q8NB46 Q8TB22 Q96SD1 Q9UGJ0	0:0:0:0:0:0	hu.MAP
DCLRE1C PRKAG2 TRIM26 ZSWIM8	A7E2V4 Q12899 Q96SD1 Q9UGJ0	0:0:0:0	hu.MAP
ANKRD52 DCLRE1C ZSWIM8	A7E2V4 Q8NB46 Q96SD1	0:0:0	hu.MAP
ANKRD52 DCLRE1C PRKAG2 ZSWIM8	A7E2V4 Q8NB46 Q96SD1 Q9UGJ0	0:0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyPolymer Precipitation	Mass spectrometry	8	31196968 32489530 37786918 34817906 28986585 32782317 27894104 38321535

Sequence, Structure & Domains10

Sequences

Length

1,837

Mass

197,297

Sequence

MELMFAEWEDGERFSFEDSDRFEEDSLCSFISEAESLCQNWRGWRKQSAGPNSPTGGGGGGGSGGTRMRDGLVIPLVELSAKQVAFHIPFEVVEKVYPPVPEQLQLRIAFWSFPENEEDIRLYSCLANGSADEFQRGDQLFRMRAVKDPLQIGFHLSATVVPPQMVPPKGAYNVAVMFDRCRVTSCSCTCGAGAKWCTHVVALCLFRIHNASAVCLRAPVSESLSRLQRDQLQKFAQYLISELPQQILPTAQRLLDELLSSQSTAINTVCGAPDPTAGPSASDQSTWYLDESTLTDNIKKTLHKFCGPSPVVFSDVNSMYLSSTEPPAAAEWACLLRPLRGREPEGVWNLLSIVREMFKRRDSNAAPLLEILTDQCLTYEQITGWWYSVRTSASHSSASGHTGRSNGQSEVAAHACASMCDEMVTLWRLAVLDPALSPQRRRELCTQLRQWQLKVIENVKRGQHKKTLERLFPGFRPAVEACYFNWEEAYPLPGVTYSGTDRKLALCWARALPSRPGASRSGGLEESRDRPRPLPTEPAVRPKEPGTKRKGLGEGVPSSQRGPRRLSAEGGDKALHKMGPGGGKAKALGGAGSGSKGSAGGGSKRRLSSEDSSLEPDLAEMSLDDSSLALGAEASTFGGFPESPPPCPLHGGSRGPSTFLPEPPDTYEEDGGVYFSEGPEPPTASVGPPGLLPGDVCTQDDLPSTDESGNGLPKTKEAAPAVGEEDDDYQAYYLNAQDGAGGEEEKAEGGAGEEHDLFAGLKPLEQESRMEVLFACAEALHAHGYSSEASRLTVELAQDLLANPPDLKVEPPPAKGKKNKVSTSRQTWVATNTLSKAAFLLTVLSERPEHHNLAFRVGMFALELQRPPASTKALEVKLAYQESEVAALLKKIPLGPSEMSTMRCRAEELREGTLCDYRPVLPLMLASFIFDVLCAPGSRPPSRNWNSETPGDEELGFEAAVAALGMKTTVSEAEHPLLCEGTRREKGDLALALMITYKDDQAKLKKILDKLLDRESQTHKPQTLSSFYSSSRPTTASQRSPSKHGGPSAPGALQPLTSGSAGPAQPGSVAGAGPGPTEGFTEKNVPESSPHSPCEGLPSEAALTPRPEGKVPSRLALGSRGGYNGRGWGSPGRPKKKHTGMASIDSSAPETTSDSSPTLSRRPLRGGWAPTSWGRGQDSDSISSSSSDSLGSSSSSGSRRASASGGARAKTVEVGRYKGRRPESHAPHVPNQPSEAAAHFYFELAKTVLIKAGGNSSTSIFTHPSSSGGHQGPHRNLHLCAFEIGLYALGLHNFVSPNWLSRTYSSHVSWITGQAMEIGSAALTILVECWDGHLTPPEVASLADRASRARDSNMVRAAAELALSCLPHAHALNPNEIQRALVQCKEQDNLMLEKACMAVEEAAKGGGVYPEVLFEVAHQWFWLYEQTAGGSSTAREGATSCSASGIRAGGEAGRGMPEGRGGPGTEPVTVAAAAVTAAATVVPVISVGSSLYPGPGLGHGHSPGLHPYTALQPHLPCSPQYLTHPAHPAHPMPHMPRPAVFPVPSSAYPQGVHPAFLGAQYPYSVTPPSLAATAVSFPVPSMAPITVHPYHTEPGLPLPTSVACELWGQGTVSSVHPASTFPAIQGASLPALTTQPSPLVSGGFPPPEEETHSQPVNPHSLHHLHAAYRVGMLALEMLGRRAHNDHPNNFSRSPPYTDDVKWLLGLAAKLGVNYVHQFCVGAAKGVLSPFVLQEIVMETLQRLSPAHAHNHLRAPAFHQLVQRCQQAYMQYIHHRLIHLTPADYDDFVNAIRSARSAFCLTPMGMMQFNDILQNLKRSKQTKELWQRVSLEMATFSP

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=A7E2V4-1; Sequence=Displayed; Name=2; IsoId=A7E2V4-2; Sequence=VSP_029590, VSP_029591; Name=3; IsoId=A7E2V4-3; Sequence=VSP_029586, VSP_029587, VSP_029590; Name=4; IsoId=A7E2V4-4; Sequence=VSP_029586; Name=5; IsoId=A7E2V4-5; Sequence=VSP_029590

Alternative Sequence

936; P -> PVVSPT (in isoform 3 and isoform 4); 1006; K -> KVTASVFQ (in isoform 3); 1604..1612; CELWGQGTV -> L (in isoform 2, isoform 3 and isoform 5); 1712..1837; VNYVHQFCVGAAKGVLSPFVLQEIVMETLQRLSPAHAHNHLRAPAFHQLVQRCQQAYMQYIHHRLIHLTPADYDDFVNAIRSARSAFCLTPMGMMQFNDILQNLKRSKQTKELWQRVSLEMATFSP -> DRHGDAAAAESRSCPQPPACPGLPPTGAALPAGIHAVHPPPLDSPDSCGLRRLCECDPECPQRLLPDAHGHDAVQRHPTEPQAQQTDQGAVAAGLTRDGHLLPLSLSPLGSYTGTQACGYGGPSHRGSETWLDRSSSLSSLVAQTDSCSWAIAWGQDVSHPRSLGLGETALSGRGRWVASGIYLAFINI (in isoform 2)

Domain & Motif Annotations

Compositional Bias

55..65; Gly residues; 523..532; Basic and acidic residues; 566..575; Basic and acidic residues; 579..602; Gly residues; 1019..1040; Polar residues; 1119..1130; Gly residues; 1144..1159; Polar residues; 1174..1209; Low complexity; 1210..1226; Basic and acidic residues; 1447..1464; Gly residues

Zinc Finger

172..208; SWIM-type

Region

45..65; Disordered; 514..727; Disordered; 803..823; Disordered; 1016..1232; Disordered; 1442..1464; Disordered; 1635..1656; Disordered

Protein Families

ZSWIM8 family

Sequence Similarities

Belongs to the ZSWIM8 family.

Clinical Relevance1

Antibody

HPA041244

Supporting Publications1

PMID	Title	Abstract
34265469	Proteomic Landscape of Exosomes Reveals the Functional Contributions of CD151 in Triple-Negative Breast Cancer.	Furthermore, utilizing quantitative proteomics approach to reveal the proteomes of CD151-deleted exosomes and cells, we found that exosomal CD151 facilitated secretion of ribosomal proteins via exosomes while inhibiting exosome secretion of complement proteins. Moreover, we proved that CD151-deleted exosomes significantly decreased the migration and invasion of TNBC cells. Most importantly, we found that the tetraspanin CD151 expression levels in TNBC-derived serum exosomes were significantly higher than those exosomes from healthy subjects, and we validated our findings with samples from 16 additional donors. This is the first comparative study of the proteomes of TNBC patient-derived and CD151-deleted exosomes.