Protein detail

ZN839

Zinc finger protein 839 (Renal carcinoma antigen NY-REN-50)

Entry name ZN839	UniProt ID A8K0R7	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Zinc finger protein 839 (Renal carcinoma antigen NY-REN-50)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000022976

Entrez Gene Symbol

ZNF839

Gene Synonym

C14orf131

Gene Description

Zinc finger protein 839

Chromosome

Position

102317377-102342702

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Cell SpecificBrain excitatory neurons

Function & Pathway5

Protein Function

Predicted intracellular proteins

Molecular Function

GO:0046872 metal ion binding

Biological Process (3)

Reactome

R-hsa-73857 rna polymerase ii transcription

Mediation Categories

Other mediation

Relations & Evidence3

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry [LTQ-FT Ultra]Mass spectrometry	1	36293200

Sequence, Structure & Domains8

Sequences

Length

811

Mass

87,484

Sequence

MLLPTTIQPQTARKSQLPRGNSCLVGLHIASPQLLRVQPLVRTEPQSCFLSDLCQPPAQGFVQRPLPALQVVPAKRVPAPKAPDEQGSMLTPLSASDPLAVTSLSSSSAHPFISNLHTRHTEKLKKSLKVKTRSGRVSRPPKYKAKDYKFIKTEDLADGHLSDSDDYSELCVEEDEDQRERHALFDLSSCSLRPKSFKCQTCEKSYIGKGGLARHFKLNPGHGQLDPEMVLSEKASGSTLRGCTEERTLSLTSLGLSMPADPCEGGARSCLVTESARGGLQNGQSVDVEETLPSEPENGALLRSERYQGPRRRACSETLAESRTAVLQQRRAAQLPGGPAAAGEQRASPSKARLKEFLQQCDREDLVELALPQLAQVVTVYEFLLMKVEKDHLAKPFFPAIYKEFEELHKMVKKMCQDYLSSSGLCSQETLEINNDKVAESLGITEFLRKKEIHPDNLGPKHLSRDMDGEQLEGASSEKREREAAEEGLASVKRPRREALSNDTTESLAANSRGREKPRPLHALAAGFSPPVNVTVSPRSEESHTTTVSGGNGSVFQAGPQLQALANLEARRGSIGAALSSRDVSGLPVYAQSGEPRRLTQAQVAAFPGENALEHSSDQDTWDSLRSPGFCSPLSSGGGAESLPPGGPGHAEAGHLGKVCDFHLNHQQPSPTSVLPTEVAAPPLEKILSVDSVAVDCAYRTVPKPGPQPGPHGSLLTEGCLRSLSGDLNRFPCGMEVHSGQRELESVVAVGEAMAFEISNGSHELLSQGQKQIFIQTSDGLILSPPGTIVSQEEDIVTVTDAEGRACGWAR

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A8K0R7-1; Sequence=Displayed; Name=2; IsoId=A8K0R7-2; Sequence=VSP_032760; Name=3; IsoId=A8K0R7-5; Sequence=VSP_040648

Alternative Sequence

1; M -> MADAEPEAGGGSEDGGGGGGPAPPGQSGSVARVAPLGPEQLRQVLEQVTKAQPPPPPPPFVLRDAARRLRDAAQQAALQRGRGTEPPRLPRLLPPQQLEAICVKVTSGETKGQERPM (in isoform 3); 527; G -> GEG (in isoform 2)

Domain & Motif Annotations

Compositional Bias

476..485; Basic and acidic residues; 501..510; Polar residues

Zinc Finger

197..222; C2H2-type

Region

329..349; Disordered; 455..555; Disordered; 612..654; Disordered

Clinical Relevance1

Antibody

HPA020434

Supporting Publications1

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available