Protein detail
KCNU1
Potassium channel subfamily U member 1 (Calcium-activated potassium channel subunit alpha-3) (Calcium-activated potassium channel, subfamily M subunit alpha-3) (KCa5) (Slowpoke homolog 3)
Protein symbol KCNU1 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 7 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Potassium channel subfamily U member 1 (Calcium-activated potassium channel subunit alpha-3) (Calcium-activated potassium channel, subfamily M subunit alpha-3) (KCa5) (Slowpoke homolog 3)
Protein Function
Human disease related genes:Reproductive system diseases:Reproductive system diseases
Transmembrane
25..45; Helical; Name=Segment S0; 102..122; Helical; Name=Segment S1; 139..159; Helical; Name=Segment S2; 164..184; Helical; Name=Segment S3; 189..209; Helical; Voltage-sensor; Name=Segment S4; 227..247; Helical; Name=Segment S5; 292..312; Helical; Name=Segment S6
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
Human disease related genes:Reproductive system diseases:Reproductive system diseases
Cellular Component
Molecular Function
Biological Process
KEGG
Canonical Pathways
M195 Pid cmyb pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
21 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| ion_channel | ion_channel | DGIdb | No | Yes | No | No | No |
| calcium_activated_potassium | ion_channel | HGNC | No | Yes | No | No | No |
| ion_channel | ion_channel | HGNC | No | Yes | No | No | No |
| ion_channel | ion_channel | Almen2009 | No | Yes | No | No | No |
| calcium_activated_potassium | ion_channel | Almen2009 | No | Yes | No | No | No |
| voltage_gated | ion_channel | Almen2009 | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| ion_channel | ion_channel | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Western blotting；RNA Sequencing；Flow cytometry；ELISA | 1 | 40730843 |
Sequence, Structure & Domains
Sequences
Length
1,149
Mass
129,543
Sequence
MFQTKLRNETWEDLPKMSCTTEIQAAFILSSFVTFFSGLIILLIFRLIWRSVKKWQIIKGTGIILELFTSGTIARSHVRSLHFQGQFRDHIEMLLSAQTFVGQVLVILVFVLSIGSLIIYFINSADPVGSCSSYEDKTIPIDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIPPTFISYYLKSNWLGLRFLRALRLLELPQILQILRAIKTSNSVKFSKLLSIILSTWFTAAGFIHLVENSGDPWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGRTFIMFFTLGSLILFANYIPEMVELFANKRKYTSSYEALKGKKFIVVCGNITVDSVTAFLRNFLRDKSGEINTEIVFLGETPPSLELETIFKCYLAYTTFISGSAMKWEDLRRVAVESAEACLIIANPLCSDSHAEDISNIMRVLSIKNYDSTTRIIIQILQSHNKVYLPKIPSWNWDTGDNIICFAELKLGFIAQGCLVPGLCTFLTSLFVEQNKKVMPKQTWKKHFLNSMKNKILTQRLSDDFAGMSFPEVARLCFLKMHLLLIAIEYKSLFTDGFCGLILNPPPQVRIRKNTLGFFIAETPKDVRRALFYCSVCHDDVFIPELITNCGCKSRSRQHITVPSVKRMKKCLKGISSRISGQDSPPRVSASTSSISNFTTRTLQHDVEQDSDQLDSSGMFHWCKPTSLDKVTLKRTGKSKYKFRNHIVACVFGDAHSAPMGLRNFVMPLRASNYTRKELKDIVFIGSLDYLQREWRFLWNFPQIYILPGCALYSGDLHAANIEQCSMCAVLSPPPQPSSNQTLVDTEAIMATLTIGSLQIDSSSDPSPSVSEETPGYTNGHNEKSNCRKVPILTELKNPSNIHFIEQLGGLEGSLQETNLHLSTAFSTGTVFSGSFLDSLLATAFYNYHVLELLQMLVTGGVSSQLEQHLDKDKVYGVADSCTSLLSGRNRCKLGLLSLHETILSDVNPRNTFGQLFCGSLDLFGILCVGLYRIIDEEELNPENKRFVITRPANEFKLLPSDLVFCAIPFSTACYKRNEEFSLQKSYEIVNKASQTTETHSDTNCPPTIDSVTETLYSPVYSYQPRTNSLSFPKQIAWNQSRTNSIISSQIPLGDNAKENERKTSDEVYDEDPFAYSEPL
3D Structural Models
Turn
382..385; 466..469; 882..884
Helix
342..349; 397..403; 405..407; 422..439; 452..456; 457..460; 475..488; 492..498; 512..521; 532..534; 539..549; 593..597; 598..600; 697..700; 732..735; 736..739; 745..747; 757..763; 764..767; 783..788; 791..793; 815..825; 868..870; 871..878; 889..891; 893..897; 903..908; 909..915; 917..928; 972..975; 982..993
Beta Strand
333..338; 363..365; 386..388; 408..413; 445..448; 471..473; 527..529; 553..558; 571..573; 585..591; 685..690; 716..720; 751..755; 771..778; 795..800; 861..864; 899..901; 962..966; 968..971; 996..1003; 1015..1020; 1032..1037
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
830..840; Low complexity; 1125..1135; Basic and acidic residues
Motif
276..279; Selectivity for potassium
Domain (CC)
The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor.; DOMAIN: The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium (By similarity).; DOMAIN: The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel.; DOMAIN: The C-terminal cytosolic region confers the pH-dependence.
Domain (FT)
331..473; RCK N-terminal 1; 713..884; RCK N-terminal 2
Region
828..854; Disordered; 1118..1149; Disordered
Protein Families
- Potassium channel family
- Calcium-activated (TC 1.A.1.3) subfamily
- KCa5.1/KCNU1 sub-subfamily
Sequence Similarities
Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa5.1/KCNU1 sub-subfamily.