Protein detail
MYO1G
Unconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2 (mHag HA-2)]
Entry name MYO1G | UniProt ID | EVMP confidence score 0.72 |
Supporting publications (n) 13 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Unconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2 (mHag HA-2)]
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
HA-2
Gene Description
Myosin IG
Chromosome
7
Position
44962662-44979088
Supporting publications (n)
13
EVMP confidence score
0.72
Fluorescence & Localization4
Tissue SpecificbrainCell SpecificBreast lactating cellsSingle-Nuclei Brain Specificoligodendrocyte
Function & Pathway7
Protein Function
Predicted intracellular proteins
Cellular Component (12)
- GO:0001891 phagocytic cup
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005886 plasma membrane
- GO:0005902 microvillus
- GO:0015629 actin cytoskeleton
- GO:0016020 membrane
- GO:0016459 myosin complex
- GO:0030027 lamellipodium
- GO:0030175 filopodium
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Molecular Function (7)
Biological Process (3)
KEGG (3)
Canonical Pathways (3)
- M290 Pid il12 stat4 pathway
- M88 Pid cd8 tcr pathway
- M54 Pid il12 2pathway
Mediation Categories (3)
Adhesion and uptake mediationFusion and delivery mediationImmune mediation
Relations & Evidence7
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometryWestern blottingFlow cytometryELISA | 10 | 31196968409280273150850034817906268848413768636638321535400983464031161632795414 |
Sequence, Structure & Domains10
Sequences
Length
1,018
Mass
116,442
Sequence
MEDEEGPEYGKPDFVLLDQVTMEDFMRNLQLRFEKGRIYTYIGEVLVSVNPYQELPLYGPEAIARYQGRELYERPPHLYAVANAAYKAMKHRSRDTCIVISGESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKDVLLKSTCVLEAFGNARTNRNHNSSRFGKYMDINFDFKGDPIGGHIHSYLLEKSRVLKQHVGERNFHAFYQLLRGSEDKQLHELHLERNPAVYNFTHQGAGLNMTVHSALDSDEQSHQAVTEAMRVIGFSPEEVESVHRILAAILHLGNIEFVETEEGGLQKEGLAVAEEALVDHVAELTATPRDLVLRSLLARTVASGGRELIEKGHTAAEASYARDACAKAVYQRLFEWVVNRINSVMEPRGRDPRRDGKDTVIGVLDIYGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQEQEEYEREGITWQSVEYFNNATIVDLVERPHRGILAVLDEACSSAGTITDRIFLQTLDMHHRHHLHYTSRQLCPTDKTMEFGRDFRIKHYAGDVTYSVEGFIDKNRDFLFQDFKRLLYNSTDPTLRAMWPDGQQDITEVTKRPLTAGTLFKNSMVALVENLASKEPFYVRCIKPNEDKVAGKLDENHCRHQVAYLGLLENVRVRRAGFASRQPYSRFLLRYKMTCEYTWPNHLLGSDKAAVSALLEQHGLQGDVAFGHSKLFIRSPRTLVTLEQSRARLIPIIVLLLQKAWRGTLARWRCRRLRAIYTIMRWFRRHKVRAHLAELQRRFQAARQPPLYGRDLVWPLPPAVLQPFQDTCHALFCRWRARQLVKNIPPSDMPQIKAKVAAMGALQGLRQDWGCRRAWARDYLSSATDNPTASSLFAQRLKTLQDKDGFGAVLFSSHVRKVNRFHKIRNRALLLTDQHLYKLDPDRQYRVMRAVPLEAVTGLSVTSGGDQLVVLHARGQDDLVVCLHRSRPPLDNRVGELVGVLAAHCQGEGRTLEVRVSDCIPLSHRGVRRLISVEPRPEQPEPDFRCARGSFTLLWPSR
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=B0I1T2-1; Sequence=Displayed; Name=2; IsoId=B0I1T2-2; Sequence=VSP_034208, VSP_034209; Name=3; IsoId=B0I1T2-3; Sequence=VSP_034210; Name=4; IsoId=B0I1T2-4; Sequence=VSP_034211, VSP_034212
Alternative Sequence
207..230; LLRGSEDKQLHELHLERNPAVYNF -> VSPEGKGRWKNGVGKGRAASWTSL (in isoform 2); 231..1018; Missing (in isoform 2); 526..1018; Missing (in isoform 3); 652..722; KMTCEYTWPNHLLGSDKAAVSALLEQHGLQGDVAFGHSKLFIRSPRTLVTLEQSRARLIPIIVLLLQKAWR -> WHLTPITPWAIVPVWSPRGRSRGSPNSTSQTSIQAGTSTLLASRHQNIWEDMCVSTCMWGHTGGNMGMRAV (in isoform 4); 723..1018; Missing (in isoform 4)
Domain & Motif Annotations
Domain (CC)
The myosin tail domain mediates binding to phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P2), phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) and binds to membranous compartments. It is required for recruitment to Fc-gamma receptor (Fc-gamma-R) phagocytic cups.
Domain (FT)
9..707; Myosin motor; 710..739; IQ; 824..1017; TH1
Region
584..606; Actin-binding
Protein Families (2)
- TRAFAC class myosin-kinesin ATPase superfamily
- Myosin family
Sequence Similarities
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Clinical Relevance1
Antibody
Supporting Publications13
| PMID | Title | Abstract |
|---|---|---|
| 40840701 | Multiomics analysis to evaluate the enrichment of extracellular vesicles from human plasma. | No abstract available |
| 41068253 | Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression. | No abstract available |
| 41307968 | Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System. | No abstract available |
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