Protein detail

MYO9A

Unconventional myosin-IXa (Unconventional myosin-9a)

Entry name MYO9A	UniProt ID B2RTY4	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Unconventional myosin-IXa (Unconventional myosin-9a)

Protein Class

Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function

Disease related genes
Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Predicted intracellular proteins

Transmembrane

175..195; Helical

Transmembrane Count

Ensembl

ENSG00000066933

Entrez Gene Symbol

MYO9A

Gene Synonym

FLJ11061FLJ13244MGC71859

Gene Description

Myosin IXA

Chromosome

Position

71822291-72118577

Frequency

EVMP Score

0.50

Fluorescence & Localization

Brain Regional Specificcerebral cortexCell SpecificBasal prostatic cellsSingle-Nuclei Brain SpecificfibroblastBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells

Function & Pathway

Protein Function

Disease related genes
Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04814 Motor proteins

Reactome

Canonical Pathways

M243 Pid arf 3pathway
M290 Pid il12 stat4 pathway
M196 Pid il23 pathway

Mediation Categories

Receptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

10 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
MYO9A	B2RTY4	RHOA	P61586	Yes	No	Yes	SIGNOR	SIGNOR:32203420

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blottingR SequencingFlow cytometryMORPHELISA	15	31320591 39290459 39949490 40928027 31508500 38225453 41227296 32795414 38731868 26775013 30071318 33709510 38490958 40098346 40311616 40091455

Sequence, Structure & Domains

Sequences

Length

2,548

Mass

292,706

Sequence

MNINDGGRRRFEDNEHTLRIYPGAISEGTIYCPIPARKNSTAAEVIESLINKLHLDKTKCYVLAEVKEFGGEEWILNPTDCPVQRMMLWPRMALENRLSGEDYRFLLREKNLDGSIHYGSLQSWLRVTEERRRMMERGFLPQPQQKDFDDLCSLPDLNEKTLLENLRNRFKHEKIYTYVGSILIVINPFKFLPIYNPKYVKMYDNHQLGKLEPHIYAVADVAYHAMLQRKKNQCIVISGESGSGKTQSTNFLIHHLTALSQKGFASGVEQIILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYQETGTVLGAYVEKYLLEKSRLVYQEHNERNYHVFYYLLAGASEDERSAFHLKQPEEYHYLNQITKKPLRQSWDDYCYDSEPDCFTVEGEDLRHDFERLQLAMEMVGFLPKTRRQIFSLLSAILHLGNICYKKKTYRDDSIDICNPEVLPIVSELLEVKEEMLFEALVTRKTVTVGEKLILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALLNSKDLEHNTKTLSIGVLDIFGFEDYENNSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISWHNIDYIDNTCCINLISKKPTGLLHLLDEESNFPQATNQTLLDKFKHQHEDNSYIEFPAVMEPAFIIKHYAGKVKYGVKDFREKNTDHMRPDIVALLRSSKNAFISGMIGIDPVAVFRWAILRAFFRAMVAFREAGKRNIHRKTGHDDTAPCAILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLSDLQGMNALNEKNQHDTFDIAWNGRTGIRQSRLSSGTSLLDKDGIFANSTSSKLLERAHGILTRNKNFKSKPALPKHLLEVNSLKHLTRLTLQDRITKSLLHLHKKKKPPSISAQFQASLSKLMETLGQAEPYFVKCIRSNAEKLPLRFSDVLVLRQLRYTGMLETVRIRQSGYSSKYSFQDFVSHFHVLLPRNIIPSKFNIQDFFRKINLNPDNYQVGKTMVFLKEQERQHLQDLLHQEVLRRIILLQRWFRVLLCRQHFLHLRQASVIIQRFWRNYLNQKQVRDAAVQKDAFVMASAAALLQASWRAHLERQRYLELRAAAIVIQQKWRDYYRRRHMAAICIQARWKAYRESKRYQEQRKKIILLQSTCRGFRARQRFKALKEQRLRETKPEVGLVNIKGYGSLEIQGSDPSGWEDCSFDNRIKAIEECKSVIESNRISRESSVDCLKESPNKQQERAQSQSGVDLQEDVLVRERPRSLEDLHQKKVGRAKRESRRMRELEQAIFSLELLKVRSLGGISPSEDRRWSTELVPEGLQSPRGTPDSESSQGSLELLSYEESQKSKLESVISDEGDLQFPSPKISSSPKFDSRDNALSASNETSSAEHLKDGTMKEMVVCSSESITCKPQLKDSFISNSLPTFFYIPQQDPLKTNSQLDTSIQRNKLLENEDTAGEALTLDINRETRRYHCSGKDQIVPSLNTESSNPVLKKLEKLNTEKEERQKQLQQQNEKEMMEQIRQQTDILEKERKAFKTIEKPRIGECLVAPSSYQSKQRVERPSSLLSLNTSNKGELNVLGSLSLKDAALAQKDSSSAHLPPKDRPVTVFFERKGSPCQSSTVKELSKTDRMGTQLNVACKLSNNRISKREHFRPTQSYSHNSDDLSREGNARPIFFTPKDNMSIPLVSKEALNSKNPQLHKEDEPAWKPVKLAGPGQRETSQRFSSVDEQAKLHKTMSQGEITKLAVRQKASDSDIRPQRAKMRFWAKGKQGEKKTTRVKPTTQSEVSPLFAGTDVIPAHQFPDELAAYHPTPPLSPELPGSCRKEFKENKEPSPKAKRKRSVKISNVALDSMHWQNDSVQIIASVSDLKSMDEFLLKKVNDLDNEDSKKDTLVDVVFKKALKEFRQNIFSFYSSALAMDDGKSIRYKDLYALFEQILEKTMRLEQRDSLGESPVRVWVNTFKVFLDEYMNEFKTSDCTATKVPKTERKKRRKKETDLVEEHNGHIFKATQYSIPTYCEYCSSLIWIMDRASVCKLCKYACHKKCCLKTTAKCSKKYDPELSSRQFGVELSRLTSEDRTVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAESVNLDDYNIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEDTNRMSANALAIVFAPCILRCPDTTDPLQSVQDISKTTTCVELIVVEQMNKYKARLKDISSLEFAENKAKTRLSLIRRSMGKGRIRRGNYPGPSSPVVVRLPSVSDVSEETLTSEAAMETDITEQQQAAMQQEERVLTEQIENLQKEKEELTFEMLVLEPRASDDETLESEASIGTADSSENLNMESEYAISEKSERSLALSSLKTAGKSEPSSKLRKQLKKQQDSLDVVDSSVSSLCLSNTASSHGTRKLFQIYSKSPFYRAASGNEALGMEGPLGQTKFLEDKPQFISRGTFNPEKGKQKLKNVKNSPQKTKETPEGTVMSGRRKTVDPDCTSNQQLALFGNNEFMV

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=B2RTY4-1; Sequence=Displayed; Name=2; IsoId=B2RTY4-2; Sequence=VSP_035157; Name=3; IsoId=B2RTY4-3; Sequence=VSP_035158, VSP_035159; Name=4; IsoId=B2RTY4-4; Sequence=VSP_035160; Name=5; IsoId=B2RTY4-5; Sequence=VSP_035156

Alternative Sequence

45..280; Missing (in isoform 5); 367..385; Missing (in isoform 2); 729; H -> K (in isoform 3); 730..2548; Missing (in isoform 3); 1714; E -> EVARPAHKKKARMARTRSDFLTRGTFADGEGDTEEDDYDDIIEPLLSLDQASHCELGPAPSLGQASHSDSEM (in isoform 4)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

1223..1236; Basic and acidic residues; 1324..1337; Low complexity; 1356..1366; Low complexity; 1372..1381; Polar residues; 1818..1830; Basic and acidic residues

Coiled Coil

1264..1291; 1486..1532; 2315..2358

Zinc Finger

1999..2048; Phorbol-ester/DAG-type 1; 2068..2119; Phorbol-ester/DAG-type 2

Domain (FT)

14..112; Ras-associating; 146..1016; Myosin motor; 1021..1041; IQ 1; 1042..1071; IQ 2; 1074..1103; IQ 3; 1115..1144; IQ 4; 1138..1167; IQ 5; 2063..2251; Rho-GAP

Region

898..920; Actin-binding; 1021..1162; Neck or regulatory domain; 1163..2511; Tail; 1223..1250; Disordered; 1299..1386; Disordered; 1804..1836; Disordered; 2359..2383; Disordered; 2401..2424; Disordered; 2490..2531; Disordered

Protein Families

TRAFAC class myosin-kinesin ATPase superfamily
Myosin family

Sequence Similarities

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

Clinical Relevance

Disease Involvement

Congenital myasthenic syndromeDisease variant

Antibody

HPA039812 HPA040071

Interaction Protein

ENSG00000070831

Interaction Count

Interaction Dataset

intact_biogrid