Protein detail
MYO1C
Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb)
Entry name MYO1C | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb)
Protein Class
Predicted intracellular proteinsTransporters
Protein Function
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
MyoICmyr2NMI
Gene Description
Myosin IC
Chromosome
17
Position
1464186-1492686
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificMyonucleiSecretome LocationIntracellular and membraneSecretome FunctionReceptor
Function & Pathway
Protein Function
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Cellular Component
- GO:0005654 nucleoplasm
- GO:0005730 nucleolus
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005902 microvillus
- GO:0005903 brush border
- GO:0005938 cell cortex
- GO:0009925 basal plasma membrane
- GO:0015629 actin cytoskeleton
- GO:0016020 membrane
- GO:0016328 lateral plasma membrane
- GO:0016461 unconventional myosin complex
- GO:0016604 nuclear body
- GO:0030659 cytoplasmic vesicle membrane
- GO:0031941 filamentous actin
- GO:0032587 ruffle membrane
- GO:0045121 membrane raft
- GO:0045335 phagocytic vesicle
- GO:0060171 stereocilium membrane
- GO:0070062 extracellular exosome
- GO:0110016 B-WICH complex
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-5250924 b wich complex positively regulates rrna expression
- R-hsa-212165 epigenetic regulation of gene expression
- R-hsa-2029480 fcgamma receptor fcgr dependent phagocytosis
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-9658195 leishmania infection
- R-hsa-199991 membrane trafficking
- R-hsa-9664407 parasite infection
- R-hsa-5250913 positive epigenetic regulation of rrna expression
- R-hsa-9709957 sensory perception
- R-hsa-9659379 sensory processing of sound
- R-hsa-9662361 sensory processing of sound by outer hair cells of the cochlea
- R-hsa-1445148 translocation of slc2a4 glut4 to the plasma membrane
- R-hsa-5653656 vesicle mediated transport
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| GSK3B | P49841 | MYO1C | O00159 | Yes | Yes | No | SIGNOR | SIGNOR:24901984 |
| DYN2 | P50570 | MYO1C | O00159 | Yes | Yes | No | SIGNOR | SIGNOR:17257598 |
Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| B-WICH complex | BAZ1BCHEBI:18111DDX21DEKERCC6MYBBP1AMYO1CSF3B1SMARCA5 | CHEBI:18111O00159O60264O75533P35659Q03468Q9BQG0Q9NR30Q9UIG0 | 0:0:0:0:0:0:0:0:0 | SIGNOR | SIGNOR:SIGNOR-C447 | |
| B-WICH complex | BAZ1BDDX21DEKERCC6MYBBP1AMYO1CSF3B1SMARCA5SPEF2 | O00159O60264O75533P35659Q03468Q9BQG0Q9C093Q9NR30Q9UIG0 | 0:0:0:0:0:0:0:0:0 | CORUM | CORUM:6302 | 16603771 |
| B-WICH complex | BAZ1BDDX21DEKERCC6MYBBP1AMYO1CSF3B1SMARCA5 | O00159O60264O75533P35659Q03468Q9BQG0Q9NR30Q9UIG0 | 1:1:1:1:1:1:1:1 | CORUMComplexPortal | intact:EBI-13952597CORUM:6194 | 2604418416603771165144172258632625883140127698542355530315558034147552922214773024952918213263592155943225435428 |
| ASB9CALM3EWSR1MYO1CMYO1F | O00159O00160P0DP25Q01844Q96DX5 | 1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4715 | ||
| DDX21MYO1CPARP1PDS5A | O00159P09874Q29RF7Q9NR30 | 0:0:0:0 | Havugimana2012 | Havugimana2012:C_268 | ||
| CALM1MYO1C | O00159P0DP23 | 2:2 | PDB | PDB:4byf |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryWestern blotting | 1 | 37886648 |
Sequence, Structure & Domains
Sequences
Length
1,063
Mass
121,682
Sequence
MALQVELVPTGEIIRVVHPHRPCKLALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDFTEDEVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCFDRSELSDKKRPETVATQFKMSLLQLVEILQSKEPAYVRCIKPNDAKQPGRFDEVLIRHQVKYLGLLENLRVRRAGFAYRRKYEAFLQRYKSLCPETWPTWAGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDALEVRRQSLATKIQAAWRGFHWRQKFLRVKRSAICIQSWWRGTLGRRKAAKRKWAAQTIRRLIRGFVLRHAPRCPENAFFLDHVRTSFLLNLRRQLPQNVLDTSWPTPPPALREASELLRELCIKNMVWKYCRSISPEWKQQLQQKAVASEIFKGKKDNYPQSVPRLFISTRLGTDEISPRVLQALGSEPIQYAVPVVKYDRKGYKPRSRQLLLTPNAVVIVEDAKVKQRIDYANLTGISVSSLSDSLFVLHVQRADNKQKGDVVLQSDHVIETLTKTALSANRVNSININQGSITFAGGPGRDGTIDFTPGSELLITKAKNGHLAVVAPRLNSR
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=A; IsoId=O00159-1; Sequence=Displayed; Name=2; Synonyms=C; IsoId=O00159-2; Sequence=VSP_036861; Name=3; Synonyms=B, Nuclear myosin 1, NM1, NMI; IsoId=O00159-3; Sequence=VSP_036862
Alternative Sequence
1..35; Missing (in isoform 2); 1..25; MALQVELVPTGEIIRVVHPHRPCKL -> MRYRAS (in isoform 3)
3D Structural Models
Turn
265..267; 486..488
Helix
51..53; 60..72; 98..104; 109..111; 116..129; 146..160; 170..185; 225..227; 238..246; 249..254; 261..263; 280..293; 298..316; 333..342; 346..354; 371..401; 433..453; 455..464; 477..484; 490..496; 506..516; 558..562; 568..575; 580..585; 600..616; 639..649; 651..660; 668..675; 676..678; 690..701; 720..753
Beta Strand
77..80; 83..87; 134..139; 193..196; 198..206; 212..220; 269..271; 355..357; 366..368; 408..413; 415..421; 429..431; 499..503; 528..530; 535..537; 539..546; 549..554; 618..626; 663..667; 682..684; 707..710; 712..718
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Domain (CC)
Binds directly to large unilamellar vesicles (LUVs) containing phosphatidylinositol 4,5-bisphosphate (PIP2) or inositol 1,4,5-trisphosphate (InsP3). The PIP2-binding site corresponds to the myosin tail domain (PH-like) present in its tail domain (By similarity).
Domain (FT)
47..731; Myosin motor; 734..757; IQ 1; 758..786; IQ 2; 885..1059; TH1
Region
608..630; Actin-binding
Protein Families
- TRAFAC class myosin-kinesin ATPase superfamily
- Myosin family
Sequence Similarities
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.