Protein detail
SNP23
Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23)
Entry name SNP23 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23)
Protein Class (3)
Predicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (2)
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
HsT17016SNAP23ASNAP23B
Gene Description
Synaptosome associated protein 23
Chromosome
15
Position
42491233-42545356
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization5
Tissue SpecificbrainCell SpecificAdipocytesSingle-Nuclei Brain Specificcommitted oligodendrocyte precursorBlood Cell SpecificMAIT T-cellBlood Lineage SpecificT-cells
Function & Pathway7
Protein Function (2)
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Cellular Component (16)
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005739 mitochondrion
- GO:0005886 plasma membrane
- GO:0005912 adherens junction
- GO:0005925 focal adhesion
- GO:0030670 phagocytic vesicle membrane
- GO:0031201 SNARE complex
- GO:0035579 specific granule membrane
- GO:0042581 specific granule
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Molecular Function (4)
Biological Process (3)
Reactome (19)
- R-hsa-1280218 adaptive immune system
- R-hsa-1236975 antigen processing cross presentation
- R-hsa-9013148 cdc42 gtpase cycle
- R-hsa-983169 class i mhc mediated antigen processing presentation
- R-hsa-168249 innate immune system
- R-hsa-199991 membrane trafficking
- R-hsa-6798695 neutrophil degranulation
- R-hsa-9013149 rac1 gtpase cycle
- R-hsa-9013423 rac3 gtpase cycle
- R-hsa-8980692 rhoa gtpase cycle
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Mediation Categories (5)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence21
Enzyme-Mediated Modification (9)
9 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SNAP23 | PRKCA | P17252 | S | 23 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapper | ProtMapper:12930825HPRD:20068231SIGNOR:12930825phosphoELM:12930825KEA:17570479KEA:12930825HPRD:12930825 |
| SNAP23 | PRKCA | P17252 | T | 24 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapper | ProtMapper:12930825HPRD:19651622phosphoELM:12930825SIGNOR:12930825KEA:12930825HPRD:12930825 |
| SNAP23 | PRKCA | P17252 | S | 161 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapper | ProtMapper:12930825HPRD:18578522phosphoELM:12930825SIGNOR:12930825KEA:12930825HPRD:12930825HPRD:20166139 |
| SNAP23 | PRKCA | P17252 | S | 108 | phosphorylation | HPRDKEA | KEA:12930825HPRD:12930825HPRD:18578522HPRD:20166139 |
| SNAP23 | IKBKB | O14920 | S | 95 | phosphorylation | REACH_ProtMapperPhosphoSiteSparser_ProtMapperProtMapper | ProtMapper:18692471ProtMapper:23592986ProtMapper:18936782 |
| SNAP23 | PKM | P14618 | S | 95 | phosphorylation | Sparser_ProtMapperProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:28067230 |
| SNAP23 | F2 | P00734 | S | 161 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:12930825 |
| SNAP23 | F2 | P00734 | S | 23 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:12930825 |
| SNAP23 | F2 | P00734 | T | 24 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:12930825 |
Ligand-Receptor Signaling (6)
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCA | P17252 | SNP23 | O00161 | Yes | No | No | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperHPRD-phosNetworKIN_KEA | HPRD-phos:12930825ProtMapper:12930825ProtMapper:18578522phosphoELM:12930825HPRD-phos:18578522ProtMapper:19651622ProtMapper:20068231ProtMapper:20166139HPRD-phos:20068231SIGNOR:12930825KEA:17570479KEA:12930825HPRD-phos:19651622HPRD:12930825HPRD-phos:20166139 |
Protein Complex Composition (5)
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| SNARE complex (SNAP23STX1A) | SNAP23STX1A | O00161Q16623 | 1:1 | CompleatCORUM | Compleat:HC3241CORUM:915 | 12209004 |
| SNARE complex (STX11VAMP2SNAP23) | SNAP23STX11VAMP2 | O00161O75558P63027 | 1:1:1 | CompleatCORUM | CORUM:797Compleat:HC2957 | 10036234 |
| SNARE complex (STX2SNAP23) | SNAP23STX2 | O00161P32856 | 1:1 | CompleatCORUM | CORUM:801Compleat:HC1389 | 10648404 |
| SNARE complex (STX6SNAP23) | SNAP23STX6 | O00161O43752 | 1:1 | CompleatCORUM | Compleat:HC1394CORUM:820 | 11001914 |
| STX11-SNAP23 SNARE complex | SNAP23STX11 | O00161O75558 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C272 |
Sequence, Structure & Domains11
Sequences
Length
211
Mass
23,354
Sequence
MDNLSSEEIQQRAHQITDESLESTRRILGLAIESQDAGIKTITMLDEQKEQLNRIEEGLDQINKDMRETEKTLTELNKCCGLCVCPCNRTKNFESGKAYKTTWGDGGENSPCNVVSKQPGPVTNGQLQQPTTGAASGGYIKRITNDAREDEMEENLTQVGSILGNLKDMALNIGNEIDAQNPQIKRITDKADTNRDRIDIANARAKKLIDS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=SNAP-23a; IsoId=O00161-1; Sequence=Displayed; Name=SNAP-23b; IsoId=O00161-2; Sequence=VSP_006187, VSP_006188
Alternative Sequence
89; R -> S (in isoform SNAP-23b); 90..142; Missing (in isoform SNAP-23b)
3D Structural Models
Helix
24..74
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Coiled Coil
23..76
Domain (FT)
14..76; t-SNARE coiled-coil homology 1; 146..208; t-SNARE coiled-coil homology 2
Protein Families
SNAP-25 family
Sequence Similarities
Belongs to the SNAP-25 family.
Clinical Relevance5
Drug Targets
Successful target
Interaction Protein (12)
ENSG00000049245ENSG00000079689ENSG00000079950ENSG00000105402ENSG00000106089ENSG00000117758ENSG00000118640ENSG00000135604ENSG00000135823ENSG00000166900ENSG00000186908ENSG00000220205
Interaction Count
12
Interaction Dataset (3)
intact_biogrid_opencellintact_biogridbiogrid_opencell
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 41307968 | Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System. | No abstract available |