Protein detail
ARVC
Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome)
Entry name ARVC | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information10
Protein Names
Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Description
ARVCF delta catenin family member
Chromosome
22
Position
19969896-20016823
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization1
Cell SpecificcDC
Function & Pathway5
Protein Function
Predicted intracellular proteins
Cellular Component (4)
Molecular Function (2)
Biological Process (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence13
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ARVCF | PRKDC | P78527 | S | 269 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (7)
7 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ARVC | O00192 | CADH5 | P33151 | Yes | Yes | No | SIGNOR | SIGNOR:14610055 |
| ARVC | O00192 | ERBIN | Q96RT1 | Yes | Yes | No | SIGNORELMHINTHPRDInnateDBLit-BM-17 | ELM:22087225HPRD:11821434Lit-BM-17:11821434ELM:24550280HINT:24550280Lit-BM-17:24550280SIGNOR:11821434ELM:22889411HINT:11821434ELM:11821434HINT:15123239InnateDB:15123239 |
| ARVC | O00192 | CADH2 | P19022 | Yes | Yes | No | HPRDSIGNOR | HPRD:11058098SIGNOR:14610055 |
| ARVC | O00192 | CADH3 | P22223 | Yes | Yes | No | SIGNOR | SIGNOR:14610055 |
| ZO1 | Q07157 | ARVC | O00192 | Yes | Yes | No | HPRDSIGNOR | HPRD:15456900SIGNOR:15456900 |
| ARVC | O00192 | CADH1 | P12830 | Yes | Yes | No | HPRDSIGNOR | HPRD:11058098SIGNOR:14610055 |
| ZO2 | Q9UDY2 | ARVC | O00192 | Yes | No | Yes | SIGNOR | SIGNOR:15456900 |
Sequence, Structure & Domains12
Sequences
Length
962
Mass
104,642
Sequence
MEDCNVHSAASILASVKEQEARFERLTRALEQERRHVALQLERAQQPGMVSGGMGSGQPLPMAWQQLVLQEQSPGSQASLATMPEAPDVLEETVTVEEDPGTPTSHVSIVTSEDGTTRRTETKVTKTVKTVTTRTVRQVPVGPDGLPLLDGGPPLGPFADGALDRHFLLRGGGPVATLSRAYLSSGGGFPEGPEPRDSPSYGSLSRGLGMRPPRAGPLGPGPGDGCFTLPGHREAFPVGPEPGPPGGRSLPERFQAEPYGLEDDTRSLAADDEGGPELEPDYGTATRRRPECGRGLHTRAYEDTADDGGELADERPAFPMVTAPLAQPERGSMGSLDRLVRRSPSVDSARKEPRWRDPELPEVLAMLRHPVDPVKANAAAYLQHLCFENEGVKRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLSYGRDTDNKAAIRDCGGVPALVRLLRAARDNEVRELVTGTLWNLSSYEPLKMVIIDHGLQTLTHEVIVPHSGWEREPNEDSKPRDAEWTTVFKNTSGCLRNVSSDGAEARRRLRECEGLVDALLHALQSAVGRKDTDNKSVENCVCIMRNLSYHVHKEVPGADRYQEAEPGPLGSAVGSQRRRRDDASCFGGKKAKEEWFHQGKKDGEMDRNFDTLDLPKRTEAAKGFELLYQPEVVRLYLSLLTESRNFNTLEAAAGALQNLSAGNWMWATYIRATVRKERGLPVLVELLQSETDKVVRAVAIALRNLSLDRRNKDLIGSYAMAELVRNVRNAQAPPRPGACLEEDTVVAVLNTIHEIVSDSLDNARSLLQARGVPALVALVASSQSVREAKAASHVLQTVWSYKELRGTLQKDGWTKARFQSAAATAKGPKGALSPGGFDDSTLPLVDKSLEGEKTGSRDVIPMDALGPDGYSTVDRRERRPRGASSAGEASEKEPLKLDPSRKAPPPGPSRPAVRLVDAVGDAKPQPVDSWV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=O00192-1; Sequence=Displayed; Name=Short; IsoId=O00192-2; Sequence=VSP_006739
Alternative Sequence
1..69; MEDCNVHSAASILASVKEQEARFERLTRALEQERRHVALQLERAQQPGMVSGGMGSGQPLPMAWQQLVL -> MPAELR (in isoform Short)
Domain & Motif Annotations
Compositional Bias
102..114; Polar residues; 206..217; Low complexity; 270..280; Acidic residues; 878..887; Basic and acidic residues; 920..932; Basic and acidic residues
Repeat
348..387; ARM 1; 390..429; ARM 2; 433..467; ARM 3; 468..508; ARM 4; 526..565; ARM 5; 575..622; ARM 6; 646..686; ARM 7; 699..738; ARM 8; 739..781; ARM 9; 782..826; ARM 10
Motif
607..623; Nuclear localization signal
Coiled Coil
8..46
Region
95..122; Disordered; 186..253; Disordered; 266..290; Disordered; 590..614; Disordered; 776..962; Required for interaction with RNA-binding proteins DDX5, HNRNPH2 and SRSF1 and with mRNAs; 854..962; Disordered
Protein Families
Beta-catenin family
Sequence Similarities
Belongs to the beta-catenin family.
Clinical Relevance2
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 39363010 | Proteomic analysis of plasma-derived extracellular vesicles: pre- and postprandial comparisons. | No abstract available |