Protein detail
LEG8
Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1)
Protein symbol LEG8 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
PCTA-1
Gene Description
Galectin 8
Chromosome
1
Position
236518000-236552981
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificplacentaCell SpecificEarly spermatidsSingle-Nuclei Brain Specificendothelial cell
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Clinical-translation mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
11 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ligand | ligand | OmniPath | Yes | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| LGALS8 | O00214 | 4 | PDB | PDB:3vknPDB:3vklPDB:7p1mPDB:3ojbPDB:3ap6PDB:9fyjPDB:7alsPDB:7p11PDB:3vkmPDB:3apbPDB:3vkoPDB:4bmePDB:3ap4PDB:9fxzPDB:6w4zPDB:7aen | ||
| ITGA1LGALS8 | O00214P56199 | 0:0 | hu.MAP2 | |||
| CALCOCO2LGALS8 | O00214Q13137 | 2:2 | PDB | PDB:4gxlPDB:4han |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | R Sequencing | 1 | 37324943 |
Sequence, Structure & Domains
Sequences
Length
317
Mass
35,808
Sequence
MMLSLNNLQNIIYNPVIPFVGTIPDQLDPGTLIVIRGHVPSDADRFQVDLQNGSSMKPRADVAFHFNPRFKRAGCIVCNTLINEKWGREEITYDTPFKREKSFEIVIMVLKDKFQVAVNGKHTLLYGHRIGPEKIDTLGIYGKVNIHSIGFSFSSDLQSTQASSLELTEISRENVPKSGTPQLRLPFAARLNTPMGPGRTVVVKGEVNANAKSFNVDLLAGKSKDIALHLNPRLNIKAFVRNSFLQESWGEEERNITSFPFSPGMYFEMIIYCDVREFKVAVNGVHSLEYKHRFKELSSIDTLEINGDIHLLEVRSW
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=I; IsoId=O00214-1; Sequence=Displayed; Name=2; IsoId=O00214-2; Sequence=VSP_003094
Alternative Sequence
183; L -> LPSNRGGDISKIAPRTVYTKSKDSTVNHTLTCTKIPPMNYVSK (in isoform 2)
3D Structural Models
Turn
56..59; 221..223; 234..237
Helix
132..134; 157..159; 297..299
Beta Strand
4..6; 9..14; 17..22; 32..38; 44..53; 61..69; 71..73; 75..82; 90..92; 102..109; 111..118; 121..127; 137..143; 145..152; 173..176; 186..193; 200..207; 213..219; 226..233; 238..245; 246..249; 256..258; 266..273; 275..282; 285..291; 302..317
3D Structure
NMR spectroscopy (1); X-ray crystallography (36)
Domain & Motif Annotations
Domain (CC)
Contains two homologous but distinct carbohydrate-binding domains.
Domain (FT)
19..152; Galectin 1; 187..317; Galectin 2