Protein detail

TR10A

Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261)

Protein symbol TR10A	UniProt ID O00220	EVMP score 0.38
Frequency	Transmembrane count 1	Protein classification Cancer-related genesCD markersPredicted membrane proteins

Basic Information

Protein Names

Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261)

Protein Class

Cancer-related genesCD markersPredicted membrane proteins

Protein Function

Cancer-related genes:Candidate cancer biomarkers
CD markers

Transmembrane

240..262; Helical

Transmembrane Count

Ensembl

ENSG00000104689

Entrez Gene Symbol

TNFRSF10A

Gene Synonym

Apo2CD261DR4TRAILR-1TRAILR1

Gene Description

TNF receptor superfamily member 10a

Chromosome

Position

23190452-23225102

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificskeletal muscleCell SpecificCytotrophoblastsSingle-Nuclei Brain Specificendothelial cell

Function & Pathway

Protein Function

Cancer-related genes:Candidate cancer biomarkers
CD markers

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M240 Pid syndecan 2 pathway

Mediation Categories

Fusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

66 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
matrix_adhesion	matrix_adhesion	Cellinker	No	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
matrix_adhesion	matrix_adhesion	OmniPath	No	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	GO_Intercell	No	No	No	Yes	No
transmembrane	transmembrane	CellPhoneDB	No	No	No	Yes	No

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Regulatory Interaction Network

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
TR10A	O00220	FADD	Q13158	Yes	Yes	No	WangMacrophageSIGNORHPRDHINTInnateDBSPIKE_LCSPIKE	HINT:10894160 HPRD:9430227 InnateDB:15452120 Macrophage:11376335 SPIKE_LC:10894160 HINT:10894161 InnateDB:10894161 SPIKE_LC:9430227 SPIKE:9430228 SPIKE_LC:9430228 Macrophage:9430227 HINT:15452120 HINT:33961781 HINT:19427028 HINT:21785459 HINT:9430227 SIGNOR:14585074 SPIKE:9430227 SPIKE_LC:16189514
TNF10	P50591	TR10A	O00220	Yes	Yes	No	iTALKKirouac2010KEGG-MEDICUSGuide2Pharma_LRdbICELLNETSIGNORHINTInnateDBUniProt_LRdbLit-BM-17HPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDCui2007IntActDLRP_talklrRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbMacrophageHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdbSPIKE	ICELLNET:11239407 HINT:10894160 SPIKE:15538968 connectomeDB2020:10549288 LRdb:15766588 connectomeDB2020:15766588 HINT:20103630 connectomeDB2020:9325248 Macrophage:12628743 Macrophage:10549288 HPRD:9082980 HPRD:9325248 HINT:10894161 Lit-BM-17:19427028 Macrophage:9082980 Baccin2019:9613612 InnateDB:10894161 SPIKE_LC:15538968 Cellinker:9325248 Cellinker:9082980 Baccin2019:9311998 HINT:26457518 Baccin2019:9314565 Lit-BM-17:9082980 Baccin2019:15766588 Baccin2019:9082980 Lit-BM-17:20103630 CellTalkDB:15766588 HPRD:10549288 LRdb:9325248 Baccin2019:9242610 IntAct:20103630 LRdb:9082980 Cellinker:15766588 LRdb:10549288 HINT:19427028 Lit-BM-17:10894160 Baccin2019:10549288 SIGNOR:14585074 Baccin2019:9325248 connectomeDB2020:9082980 Baccin2019:9430226 HPMR:15766588 Cellinker:10549288 SPIKE_LC:16189514
MARH8	Q5T0T0	TR10A	O00220	Yes	No	Yes	SIGNORBioGRID	BioGRID:23300075 SIGNOR:23300075

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	TNFRSF10A TNFSF10	O00220 P50591	3:3	PDB	PDB:5cir

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	4	31508500 38225453 38731868 33709510

Sequence, Structure & Domains

Sequences

Length

468

Mass

50,089

Sequence

MAPPPARVHLGAFLAVTPNPGSAASGTEAAAATPSKVWGSSAGRIEPRGGGRGALPTSMGQHGPSARARAGRAPGPRPAREASPRLRVHKTFKFVVVGVLLQVVPSSAATIKLHDQSIGTQQWEHSPLGELCPPGSHRSEHPGACNRCTEGVGYTNASNNLFACLPCTACKSDEEERSPCTTTRNTACQCKPGTFRNDNSAEMCRKCSRGCPRGMVKVKDCTPWSDIECVHKESGNGHNIWVILVVTLVVPLLLVAVLIVCCCIGSGCGGDPKCMDRVCFWRLGLLRGPGAEDNAHNEILSNADSLSTFVSEQQMESQEPADLTGVTVQSPGEAQCLLGPAEAEGSQRRRLLVPANGADPTETLMLFFDKFANIVPFDSWDQLMRQLDLTKNEIDVVRAGTAGPGDALYAMLMKWVNKTGRNASIHTLLDALERMEERHAREKIQDLLVDSGKFIYLEDGTGSAVSLE

3D Structural Models

Turn

150..152

Beta Strand

136..138; 145..147; 157..159; 174..178; 187..190; 216..219; 228..230

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

20..34; Low complexity; 63..74; Low complexity

Repeat

107..145; TNFR-Cys 1; 147..188; TNFR-Cys 2; 189..229; TNFR-Cys 3

Domain (FT)

365..448; Death

Region

17..82; Disordered

Clinical Relevance

Disease Involvement

Cancer-related genes

Drugs

TRAIL DULANERMIN H2O2 SULINDAC MAPATUMUMAB NULL

Antibody

HPA054475

Interaction Protein

ENSG00000064012ENSG00000108679

Interaction Count

Interaction Dataset

intact_biogrid