Protein detail

SIRB1

Signal-regulatory protein beta-1 (SIRP-beta-1) (CD172 antigen-like family member B) (CD antigen CD172b)

Entry name SIRB1	UniProt ID O00241	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 1	Protein classification CD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Signal-regulatory protein beta-1 (SIRP-beta-1) (CD172 antigen-like family member B) (CD antigen CD172b)

Protein Class (5)

CD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (3)

Predicted intracellular proteins
CD markers
Transporters:Accessory Factors Involved in Transport

Transmembrane

372..392; Helical

Transmembrane Count

Ensembl

ENSG00000101307

Entrez Gene Symbol

SIRPB1

Gene Synonym (2)

CD172bSIRP-BETA-1

Gene Description

Signal regulatory protein beta 1

Chromosome

Position

1561385-1620061

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization4

Cell SpecificAlveolar cells type 1Single-Nuclei Brain Specificendothelial cellBlood Cell Specificnon-classical monocyteBlood Lineage Specificmonocytes

Function & Pathway8

Protein Function (3)

Predicted intracellular proteins
CD markers
Transporters:Accessory Factors Involved in Transport

Cellular Component (4)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

KEGG (2)

Reactome (5)

Canonical Pathways

M271 Pid pi3k plc trk pathway

Mediation Categories (4)

Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence61

Ligand-Receptor Signaling (58)

58 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No

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Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	SIRPB1	O00241	2	PDB	PDB:2jju
	SIRPB1	Q5TFQ8	2	PDB	PDB:2jjv

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	17	31508500 38225453 39873726 32795414 38731868 25844599 25950383 26801919 27723984 30975894 37686366 41201090 28396511 30760538 37922300 36982312 40311616

Sequence, Structure & Domains9

Sequences

Length

398

Mass

43,211

Sequence

MPVPASWPHLPSPFLLMTLLLGRLTGVAGEDELQVIQPEKSVSVAAGESATLRCAMTSLIPVGPIMWFRGAGAGRELIYNQKEGHFPRVTTVSELTKRNNLDFSISISNITPADAGTYYCVKFRKGSPDDVEFKSGAGTELSVRAKPSAPVVSGPAVRATPEHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPAGDSVSYSIHSTARVVLTRGDVHSQVICEIAHITLQGDPLRGTANLSEAIRVPPTLEVTQQPMRAENQANVTCQVSNFYPRGLQLTWLENGNVSRTETASTLIENKDGTYNWMSWLLVNTCAHRDDVVLTCQVEHDGQQAVSKSYALEISAHQKEHGSDITHEAALAPTAPLLVALLLGPKLLLVVGVSAIYICWKQKA

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O00241-1; Sequence=Displayed; Name=2; IsoId=O00241-2; Sequence=VSP_007026; Name=3; IsoId=Q5TFQ8-1; Sequence=External

Alternative Sequence

145..361; Missing (in isoform 2)

3D Structural Models

Helix

112..114

Beta Strand

40..45; 50..52; 55..57; 65..69; 76..84; 89..91; 95..99; 105..107; 116..124; 127..129; 131..135; 139..144

3D Structure

NMR spectroscopy (1); X-ray crystallography (1)

Domain & Motif Annotations

Domain (FT)

30..136; Ig-like V-type; 147..246; Ig-like C1-type 1; 253..347; Ig-like C1-type 2

Clinical Relevance4

Antibody

HPA047463

Interaction Protein

ENSG00000011600

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
28211531	Proteomic analysis of urinary extracellular vesicles from high Gleason score prostate cancer.	No abstract available