Protein detail
SIRB1
Signal-regulatory protein beta-1 (SIRP-beta-1) (CD172 antigen-like family member B) (CD antigen CD172b)
Protein symbol SIRB1 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification CD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Signal-regulatory protein beta-1 (SIRP-beta-1) (CD172 antigen-like family member B) (CD antigen CD172b)
Protein Class
CD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Predicted intracellular proteins
- CD markers
- Transporters:Accessory Factors Involved in Transport
Transmembrane
372..392; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD172bSIRP-BETA-1
Gene Description
Signal regulatory protein beta 1
Chromosome
20
Position
1561385-1620061
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificAlveolar cells type 1Single-Nuclei Brain Specificendothelial cellBlood Cell Specificnon-classical monocyteBlood Lineage Specificmonocytes
Function & Pathway
Protein Function
- Predicted intracellular proteins
- CD markers
- Transporters:Accessory Factors Involved in Transport
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
M271 Pid pi3k plc trk pathway
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
58 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometry | 17 | 3150850038225453398737263279541438731868258445992595038326801919277239843097589437686366412010902839651130760538379223003698231240311616 |
Sequence, Structure & Domains
Sequences
Length
398
Mass
43,211
Sequence
MPVPASWPHLPSPFLLMTLLLGRLTGVAGEDELQVIQPEKSVSVAAGESATLRCAMTSLIPVGPIMWFRGAGAGRELIYNQKEGHFPRVTTVSELTKRNNLDFSISISNITPADAGTYYCVKFRKGSPDDVEFKSGAGTELSVRAKPSAPVVSGPAVRATPEHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPAGDSVSYSIHSTARVVLTRGDVHSQVICEIAHITLQGDPLRGTANLSEAIRVPPTLEVTQQPMRAENQANVTCQVSNFYPRGLQLTWLENGNVSRTETASTLIENKDGTYNWMSWLLVNTCAHRDDVVLTCQVEHDGQQAVSKSYALEISAHQKEHGSDITHEAALAPTAPLLVALLLGPKLLLVVGVSAIYICWKQKA
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O00241-1; Sequence=Displayed; Name=2; IsoId=O00241-2; Sequence=VSP_007026; Name=3; IsoId=Q5TFQ8-1; Sequence=External
Alternative Sequence
145..361; Missing (in isoform 2)
3D Structural Models
Helix
112..114
Beta Strand
40..45; 50..52; 55..57; 65..69; 76..84; 89..91; 95..99; 105..107; 116..124; 127..129; 131..135; 139..144
3D Structure
NMR spectroscopy (1); X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
30..136; Ig-like V-type; 147..246; Ig-like C1-type 1; 253..347; Ig-like C1-type 2
Clinical Relevance
Antibody
Interaction Protein
ENSG00000011600
Interaction Count
1
Interaction Dataset
intact_biogrid