Protein detail
S28A1
Sodium/nucleoside cotransporter 1 (Concentrative nucleoside transporter 1) (CNT 1) (hCNT1) (Na(+)/nucleoside cotransporter 1) (Sodium-coupled nucleoside transporter 1) (Solute carrier family 28 member 1)
Entry name S28A1 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 13 | Protein classification Disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Sodium/nucleoside cotransporter 1 (Concentrative nucleoside transporter 1) (CNT 1) (hCNT1) (Na(+)/nucleoside cotransporter 1) (Sodium-coupled nucleoside transporter 1) (Solute carrier family 28 member 1)
Protein Class (5)
Disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (3)
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Potential drug targets
Transmembrane
81..104; Helical; 110..128; Helical; 148..167; Helical; 179..195; Helical; 202..222; Helical; 262..283; Helical; 295..318; Helical; 338..360; Helical; 367..386; Helical; 424..446; Helical; 458..479; Helical; 535..558; Helical; 570..592; Helical
Transmembrane Count
13
Ensembl
Entrez Gene Symbol
Gene Synonym
CNT1
Gene Description
Solute carrier family 28 member 1
Chromosome
15
Position
84884654-84945798
Supporting publications (n)
1
EVMP confidence score
0.50
Function & Pathway6
Protein Function (3)
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Potential drug targets
Cellular Component (5)
Molecular Function (6)
- GO:0005345 purine nucleobase transmembrane transporter activity
- GO:0005415 nucleoside:sodium symporter activity
- GO:0015212 cytidine transmembrane transporter activity
- GO:0015213 uridine transmembrane transporter activity
- GO:0015389 pyrimidine- and adenosine-specific:sodium symporter activity
- GO:1901474 azole transmembrane transporter activity
Biological Process (3)
Reactome (4)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence24
Ligand-Receptor Signaling (23)
23 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | DGIdb | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | No | No |
| slc28 | transporter | Surfaceome | No | Yes | No | No | No |
| slc | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 36359767 |
Sequence, Structure & Domains7
Sequences
Length
649
Mass
71,584
Sequence
MENDPSRRRESISLTPVAKGLENMGADFLESLEEGQLPRSDLSPAEIRSSWSEAAPKPFSRWRNLQPALRARSFCREHMQLFRWIGTGLLCTGLSAFLLVACLLDFQRALALFVLTCVVLTFLGHRLLKRLLGPKLRRFLKPQGHPRLLLWFKRGLALAAFLGLVLWLSLDTSQRPEQLVSFAGICVFVALLFACSKHHCAVSWRAVSWGLGLQFVLGLLVIRTEPGFIAFEWLGEQIRIFLSYTKAGSSFVFGEALVKDVFAFQVLPIIVFFSCVISVLYHVGLMQWVILKIAWLMQVTMGTTATETLSVAGNIFVSQTEAPLLIRPYLADMTLSEVHVVMTGGYATIAGSLLGAYISFGIDATSLIAASVMAAPCALALSKLVYPEVEESKFRREEGVKLTYGDAQNLIEAASTGAAISVKVVANIAANLIAFLAVLDFINAALSWLGDMVDIQGLSFQLICSYILRPVAFLMGVAWEDCPVVAELLGIKLFLNEFVAYQDLSKYKQRRLAGAEEWVGDRKQWISVRAEVLTTFALCGFANFSSIGIMLGGLTSMVPQRKSDFSQIVLRALFTGACVSLVNACMAGILYMPRGAEVDCMSLLNTTLSSSSFEIYQCCREAFQSVNPEFSPEALDNCCRFYNHTICAQ
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O00337-1; Sequence=Displayed; Name=2; IsoId=O00337-2; Sequence=VSP_037221, VSP_037222
Alternative Sequence
155..175; GLALAAFLGLVLWLSLDTSQR -> DPRPWSKEGPNQYLPQITWTV (in isoform 2); 176..649; Missing (in isoform 2)
Domain & Motif Annotations
Protein Families
Concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Sequence Similarities
Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
Clinical Relevance3
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 38071653 | Extracellular vesicle proteome unveils cathepsin B connection to Alzheimer's disease pathogenesis. | No abstract available |