Protein detail
CCRL2
C-C chemokine receptor-like 2 (Chemokine receptor CCR11) (Chemokine receptor X) (Putative MCP-1 chemokine receptor)
Protein symbol CCRL2 | UniProt ID | EVMP score 0.50 |
Frequency 4 | Transmembrane count 7 | Protein classification G-protein coupled receptorsPredicted membrane proteins |
Basic Information
Protein Names
C-C chemokine receptor-like 2 (Chemokine receptor CCR11) (Chemokine receptor X) (Putative MCP-1 chemokine receptor)
Protein Class
G-protein coupled receptorsPredicted membrane proteins
Protein Function
- G-protein coupled receptors:Chemokines and chemotactic factors receptors
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
44..64; Helical; Name=1; 75..95; Helical; Name=2; 105..125; Helical; Name=3; 145..165; Helical; Name=4; 199..219; Helical; Name=5; 239..259; Helical; Name=6; 287..307; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
ACKR5CKRXCRAM-ACRAM-BHCR
Gene Description
C-C motif chemokine receptor like 2
Chromosome
3
Position
46407166-46412997
Frequency
4
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- G-protein coupled receptors:Chemokines and chemotactic factors receptors
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
60 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| gpcr | receptor | Surfaceome | No | Yes | No | Yes | No |
| class_a_rhodopsin | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_a_rhodopsin_protein | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_a_rhodopsin_protein_chemokine | receptor | GPCRdb | No | Yes | No | Yes | No |
| chemokine | receptor | ICELLNET | No | Yes | No | Yes | No |
| chemokine_cc | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | DGIdb | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
344
Mass
39,513
Sequence
MANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=CRAM-B; IsoId=O00421-1; Sequence=Displayed; Name=2; Synonyms=CRAM-A; IsoId=O00421-2; Sequence=VSP_018584
Alternative Sequence
1; M -> MIYTRFLKGSLKM (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
324..333; Polar residues; 334..344; Basic and acidic residues
Domain (CC)
Lacks the conserved DRYLAIV motif in the second intracellular loop that is required for signaling of functional chemokine receptors.
Region
324..344; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Antibody