Protein detail
IFRD1
Interferon-related developmental regulator 1 (Nerve growth factor-inducible protein PC4)
Entry name IFRD1 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Predicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Interferon-related developmental regulator 1 (Nerve growth factor-inducible protein PC4)
Protein Class (2)
Predicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
PC4TIS7
Gene Description
Interferon related developmental regulator 1
Chromosome
7
Position
112422887-112481017
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization4
Tissue SpecificbrainCell SpecificB-cellsSingle-Nuclei Brain Specificleukocyte
Function & Pathway4
Protein Function
Predicted intracellular proteins
Cellular Component (2)
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence15
Ligand-Receptor Signaling (8)
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | No | No |
Protein Complex Composition (6)
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| COMTD1IFRD1MIGA1NT5C3BTP53BP1USP28 | O00458Q12888Q86VU5Q8NAN2Q969T7Q96RU2 | 0:0:0:0:0:0 | hu.MAP2 | |||
| COMTD1IFRD1MIGA1USP28WAPL | O00458Q7Z5K2Q86VU5Q8NAN2Q96RU2 | 0:0:0:0:0 | hu.MAP2 | |||
| COMTD1IFRD1 | O00458Q86VU5 | 0:0 | hu.MAP | |||
| COMTD1IFRD1MIGA1 | O00458Q86VU5Q8NAN2 | 0:0:0 | hu.MAP2 | |||
| COMTD1IFRD1MIGA1USP28 | O00458Q86VU5Q8NAN2Q96RU2 | 0:0:0:0 | hu.MAP | |||
| COMTD1IFRD1USP28 | O00458Q86VU5Q96RU2 | 0:0:0 | hu.MAP2 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37401875 |
Sequence, Structure & Domains9
Sequences
Length
451
Mass
50,269
Sequence
MPKNKKRNTPHRGSSAGGGGSGAAAATAATAGGQHRNVQPFSDEDASIETMSHCSGYSDPSSFAEDGPEVLDEEGTQEDLEYKLKGLIDLTLDKSAKTRQAALEGIKNALASKMLYEFILERRMTLTDSIERCLKKGKSDEQRAAAALASVLCIQLGPGIESEEILKTLGPILKKIICDGSASMQARQTCATCFGVCCFIATDDITELYSTLECLENIFTKSYLKEKDTTVICSTPNTVLHISSLLAWTLLLTICPINEVKKKLEMHFHKLPSLLSCDDVNMRIAAGESLALLFELARGIESDFFYEDMESLTQMLRALATDGNKHRAKVDKRKQRSVFRDVLRAVEERDFPTETIKFGPERMYIDCWVKKHTYDTFKEVLGSGMQYHLQSNEFLRNVFELGPPVMLDAATLKTMKISRFERHLYNSAAFKARTKARSKCRDKRADVGEFF
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O00458-1; Sequence=Displayed; Name=2; IsoId=O00458-2; Sequence=VSP_044304
Alternative Sequence
1..50; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
1..10; Basic residues; 23..33; Low complexity; 49..61; Polar residues
Region
1..69; Disordered
Protein Families
IFRD family
Sequence Similarities
Belongs to the IFRD family.
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 27821849 | Detailed Analysis of Protein Topology of Extracellular Vesicles-Evidence of Unconventional Membrane Protein Orientation. | No abstract available |