Protein detail

BT3A3

Butyrophilin subfamily 3 member A3

Protein symbol BT3A3	UniProt ID O00478	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Butyrophilin subfamily 3 member A3

Protein Class

Predicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

249..269; Helical

Transmembrane Count

Ensembl

ENSG00000111801

Entrez Gene Symbol

BTN3A3

Gene Synonym

BTF3BTN3.3

Gene Description

Butyrophilin subfamily 3 member A3

Chromosome

Position

26440472-26453415

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificblood vesselCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificendothelial cell

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Reactome

Canonical Pathways

M177 Pid epha fwdpathway

Mediation Categories

Fusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

33 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	BTN3A3	O00478	4	PDB	PDB:6j0kPDB:6j0gPDB:6j0l

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	R Sequencing	2	31508500 38731868

Sequence, Structure & Domains

Sequences

Length

584

Mass

65,002

Sequence

MKMASSLAFLLLNFHVSLFLVQLLTPCSAQFSVLGPSGPILAMVGEDADLPCHLFPTMSAETMELRWVSSSLRQVVNVYADGKEVEDRQSAPYRGRTSILRDGITAGKAALRIHNVTASDSGKYLCYFQDGDFYEKALVELKVAALGSDLHIEVKGYEDGGIHLECRSTGWYPQPQIKWSDTKGENIPAVEAPVVADGVGLYAVAASVIMRGSSGGGVSCIIRNSLLGLEKTASISIADPFFRSAQPWIAALAGTLPISLLLLAGASYFLWRQQKEKIALSRETEREREMKEMGYAATEQEISLREKLQEELKWRKIQYMARGEKSLAYHEWKMALFKPADVILDPDTANAILLVSEDQRSVQRAEEPRDLPDNPERFEWRYCVLGCENFTSGRHYWEVEVGDRKEWHIGVCSKNVERKKGWVKMTPENGYWTMGLTDGNKYRALTEPRTNLKLPEPPRKVGIFLDYETGEISFYNATDGSHIYTFPHASFSEPLYPVFRILTLEPTALTICPIPKEVESSPDPDLVPDHSLETPLTPGLANESGEPQAEVTSLLLPAHPGAEVSPSATTNQNHKLQARTEALY

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O00478-1; Sequence=Displayed; Name=2; IsoId=O00478-2; Sequence=VSP_045063, VSP_045064

Alternative Sequence

1..42; Missing (in isoform 2); 307..313; Missing (in isoform 2)

3D Structural Models

Turn

70..73; 225..228; 239..241; 346..348; 438..440; 467..470; 477..479

Helix

91..93; 104..106; 118..120; 328..336; 427..429

Beta Strand

32..34; 40..43; 48..56; 63..69; 74..80; 96..100; 108..115; 122..130; 133..145; 151..158; 161..173; 176..181; 202..210; 218..224; 229..235; 337..339; 353..355; 359..364; 379..381; 383..387; 390..400; 407..413; 418..421; 431..437; 441..444; 446..448; 450..452; 459..466; 471..476; 482..485; 495..500; 509..511

3D Structure

Electron microscopy (2); X-ray crystallography (5)

Domain & Motif Annotations

Compositional Bias

566..575; Polar residues

Domain (FT)

30..139; Ig-like V-type 1; 145..236; Ig-like V-type 2; 322..518; B30.2/SPRY

Region

519..584; Disordered

Protein Families

Immunoglobulin superfamily
BTN/MOG family

Sequence Similarities

Belongs to the immunoglobulin superfamily. BTN/MOG family.

Clinical Relevance

Antibody

HPA007110 HPA007904 HPA011871