Protein detail
CLD5
Claudin-5 (Transmembrane protein deleted in VCFS) (TMDVCF)
Protein symbol CLD5 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 4 | Protein classification Predicted membrane proteinsTransporters |
Basic Information
Protein Names
Claudin-5 (Transmembrane protein deleted in VCFS) (TMDVCF)
Protein Class
Predicted membrane proteinsTransporters
Protein Function
Transporters:Transporter channels and pores
Transmembrane
8..28; Helical; 82..102; Helical; 123..143; Helical; 160..180; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym
AWALBEC1CPETRL1TMVCF
Gene Description
Claudin 5
Chromosome
22
Position
19523024-19527545
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificchoroid plexusCell SpecificBasal keratinocytesBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
Transporters:Transporter channels and pores
Cellular Component
- GO:0005886 plasma membrane
- GO:0005911 cell-cell junction
- GO:0005923 bicellular tight junction
- GO:0016020 membrane
- GO:0016327 apicolateral plasma membrane
- GO:0016328 lateral plasma membrane
- GO:0030054 cell junction
- GO:0030864 cortical actin cytoskeleton
- GO:0033270 paranode region of axon
- GO:0043220 Schmidt-Lanterman incisure
- GO:0070160 tight junction
Molecular Function
Biological Process
KEGG
Reactome
Canonical Pathways
- M273 Pid epha2 fwd pathway
- M177 Pid epha fwdpathway
- M86 Pid arf6 pathway
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | No |
| tight_junction | tight_junction | GO_Intercell | Yes | Yes | No | No | No |
| tight_junction | tight_junction | Ramilowski_location | Yes | Yes | No | No | No |
| tight_junction | tight_junction | Zhong2015 | Yes | Yes | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
218
Mass
23,147
Sequence
MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKARVALTGGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCLLCCGAWVCTGRPDLSFPVKYSAPRRPTATGDYDKKNYV
3D Structural Models
Domain & Motif Annotations
Region
217..218; Interactions with TJP1, TJP2 and TJP3
Protein Families
Claudin family
Sequence Similarities
Belongs to the claudin family.
Clinical Relevance
Antibody