Protein detail
CLD5
Claudin-5 (Transmembrane protein deleted in VCFS) (TMDVCF)
Entry name CLD5 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) | Transmembrane count 4 | Protein classification Predicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Claudin-5 (Transmembrane protein deleted in VCFS) (TMDVCF)
Protein Class (2)
Predicted membrane proteinsTransporters
Protein Function
Transporters:Transporter channels and pores
Transmembrane
8..28; Helical; 82..102; Helical; 123..143; Helical; 160..180; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
AWALBEC1CPETRL1TMVCF
Gene Description
Claudin 5
Chromosome
22
Position
19523024-19527545
EVMP confidence score
0.38
Fluorescence & Localization4
Tissue Specificchoroid plexusCell SpecificBasal keratinocytesBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway8
Protein Function
Transporters:Transporter channels and pores
Cellular Component (11)
- GO:0005886 plasma membrane
- GO:0005911 cell-cell junction
- GO:0005923 bicellular tight junction
- GO:0016020 membrane
- GO:0016327 apicolateral plasma membrane
- GO:0016328 lateral plasma membrane
- GO:0030054 cell junction
- GO:0030864 cortical actin cytoskeleton
- GO:0033270 paranode region of axon
- GO:0043220 Schmidt-Lanterman incisure
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Molecular Function (3)
Biological Process (3)
KEGG (7)
Reactome (6)
Canonical Pathways (3)
- M273 Pid epha2 fwd pathway
- M177 Pid epha fwdpathway
- M86 Pid arf6 pathway
Mediation Categories (3)
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence26
Ligand-Receptor Signaling (25)
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| ligand | ligand | CellCall | Yes | No | No | No | No |
| ligand | ligand | OmniPath | Yes | No | No | No | No |
| receptor | receptor | CellCall | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains6
Sequences
Length
218
Mass
23,147
Sequence
MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKARVALTGGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCLLCCGAWVCTGRPDLSFPVKYSAPRRPTATGDYDKKNYV
Domain & Motif Annotations
Region
217..218; Interactions with TJP1, TJP2 and TJP3
Protein Families
Claudin family
Sequence Similarities
Belongs to the claudin family.
Clinical Relevance1
Antibody