Protein detail

NCHL1

Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein]

Protein symbol NCHL1	UniProt ID O00533	EVMP score 0.25
Frequency 1	Transmembrane count 1	Protein classification Plasma proteinsPredicted membrane proteinsPredicted secreted proteins

Basic Information

Protein Names

Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein]

Protein Class

Plasma proteinsPredicted membrane proteinsPredicted secreted proteins

Protein Function

Predicted secreted proteins

Transmembrane

1083..1103; Helical

Transmembrane Count

Ensembl

ENSG00000134121

Entrez Gene Symbol

CHL1

Gene Synonym

CALLFLJ44930L1CAM2MGC132578

Gene Description

Cell adhesion molecule L1 like

Chromosome

Position

196763-409417

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue SpecificesophagusCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificependymal cellBlood Cell SpecificbasophilSecretome LocationSecreted to bloodSecretome FunctionOther

Function & Pathway

Protein Function

Predicted secreted proteins

Cellular Component

Molecular Function

GO:0002020 protease binding

Biological Process

Reactome

Canonical Pathways

M70 Pid ps1 pathway
M142 Pid ajdiss 2pathway
M17 Pid notch pathway

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

48 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
adhesion	adhesion	HGNC	Yes	Yes	Yes	Yes	No
ig_like	adhesion	Almen2009	Yes	Yes	Yes	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	Yes	Yes	No
cell_adhesion	cell_adhesion	Zhong2015	Yes	Yes	Yes	Yes	No
icam	cell_adhesion	Zhong2015	Yes	Yes	Yes	Yes	No
cell_adhesion	cell_adhesion	HGNC	Yes	Yes	Yes	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	Yes	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	Yes	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	Yes	Yes	No

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Regulatory Interaction Network

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
NCHL1	O00533	ANK3	Q12955	Yes	Yes	No	SIGNOR	SIGNOR:7961622
NCHL1	O00533	ANK2	Q01484	Yes	Yes	No	SIGNOR	SIGNOR:7961622
NCHL1	O00533	ANK1	P16157	Yes	Yes	No	SIGNOR	SIGNOR:7961622

Protein Complex Composition

7 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
PRRX1-UCHL1 complex	PRRX1 UCHL1	P09936 P54821	0:0	CORUM	CORUM:7105	29339092
PRRX2-UCHL1 complex	PRRX2 UCHL1	P09936 Q99811	0:0	CORUM	CORUM:7106	29339092
	DOHH EIF5A PNP UCHL1	P00491 P09936 P63241 Q9BU89	0:0:0:0	hu.MAP2
	UCHL1	P09936	2	PDB	PDB:7zm0PDB:4dm9PDB:8dy8PDB:8edePDB:3irtPDB:2etlPDB:8xi7PDB:4jkjPDB:8pw1
	ARF1 ARF3 GGA1 GGA2 GGA3 MON2 NEDD8 RABGEF1 RPS27A UBB UBC UCHL1	P09936 P0CG47 P0CG48 P61204 P62979 P84077 Q15843 Q7Z3U7 Q9NZ52 Q9UJ41 Q9UJY4 Q9UJY5	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4836
	UBC UCHL1	P09936 P0CG48	2:2	PDB	PDB:3kw5PDB:9o4mPDB:3kvfPDB:3ifw
	UCHL1 ULK3 WDR82	P09936 Q6PHR2 Q6UXN9	0:0:0	Havugimana2012	Havugimana2012:C_113

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	38207106

Sequence, Structure & Domains

Sequences

Length

1,208

Mass

135,071

Sequence

MEPLLLGRGLIVYLMFLLLKFSKAIEIPSSVQQVPTIIKQSKVQVAFPFDEYFQIECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSSNSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWEELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTNHTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCGKPITEESSTLGEGSKGIGKISGVNLTQKTHPIEVFEPGAEHIVRLMTKNWGDNDSIFQDVIETRGREYAGLYDDISTQGWFIGLMCAIALLTLLLLTVCFVKRNRGGKYSVKEKEDLHPDPEIQSVKDETFGEYSDSDEKPLKGSLRSLNRDMQPTESADSLVEYGEGDHGLFSEDGSFIGAYAGSKEKGSVESNGSSTATFPLRA

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O00533-1; Sequence=Displayed; Name=2; IsoId=O00533-2; Sequence=VSP_020082

Alternative Sequence

227; S -> LKHANDSSSSTEIGSKA (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

1149..1161; Polar residues; 1194..1208; Polar residues

Motif

555..558; DGEA; 1181..1185; FIG[AQ]Y

Domain (CC)

The FIG[AQ]Y motif seems to be an ankyrin recruitment region.; DOMAIN: The DGEA motif seems to be a recognition site for integrin.

Domain (FT)

35..124; Ig-like C2-type 1; 128..223; Ig-like C2-type 2; 235..328; Ig-like C2-type 3; 331..417; Ig-like C2-type 4; 423..510; Ig-like C2-type 5; 515..607; Ig-like C2-type 6; 614..709; Fibronectin type-III 1; 714..807; Fibronectin type-III 2; 809..914; Fibronectin type-III 3; 918..1015; Fibronectin type-III 4

Region

693..716; Disordered; 1131..1163; Disordered; 1189..1208; Disordered

Protein Families

Immunoglobulin superfamily
L1/neurofascin/NgCAM family

Sequence Similarities

Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

Clinical Relevance

Drugs

ANTIDEPRESSANT AGENT

Antibody

HPA003345 CAB026120