Protein detail
DLL1
Delta-like protein 1 (Drosophila Delta homolog 1) (Delta1) (H-Delta-1)
Protein symbol DLL1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Delta-like protein 1 (Drosophila Delta homolog 1) (Delta1) (H-Delta-1)
Protein Function
- Disease related genes
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Predicted intracellular proteins
Transmembrane
546..568; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificcerebellar inhibitory
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-2122948 activated notch1 transmits signal to the nucleus
- R-hsa-9734767 developmental cell lineages
- R-hsa-9734779 developmental cell lineages of the integumentary system
- R-hsa-9725554 differentiation of keratinocytes in interfollicular epidermis in mammalian skin
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-9793380 formation of paraxial mesoderm
- R-hsa-9758941 gastrulation
- R-hsa-9830369 kidney development
- R-hsa-9022702 mecp2 regulates transcription of neuronal ligands
- R-hsa-9831926 nephron development
- R-hsa-2979096 notch2 activation and transmission of signal to the nucleus
- R-hsa-9013507 notch3 activation and transmission of signal to the nucleus
- R-hsa-73857 rna polymerase ii transcription
- R-hsa-157118 signaling by notch
- R-hsa-1980143 signaling by notch1
- R-hsa-2691230 signaling by notch1 hd domain mutants in cancer
- R-hsa-2644602 signaling by notch1 pest domain mutants in cancer
- R-hsa-2660825 signaling by notch1 t 7 9 notch1 m1580 k2555 translocation mutant
- R-hsa-1980145 signaling by notch2
- R-hsa-9012852 signaling by notch3
- R-hsa-9824272 somitogenesis
- R-hsa-8986944 transcriptional regulation by mecp2
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
51 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
Regulatory Interaction Network
7 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| DLL1 | O00548 | NOTC1 | P46531 | Yes | Yes | No | iTALKKirouac2010KEGG-MEDICUSICELLNETSIGNORCellPhoneDB_CellinkerUniProt_LRdbHPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDCui2007Ramilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbHPMR_CellinkerNetPathconnectomeDB2020SPIKE_LCLRdbSPIKE | ICELLNET:21685328connectomeDB2020:9819428connectomeDB2020:11006133Cellinker:9819428CellChatDB:22353464Baccin2019:1006133CellTalkDB:22353464LRdb:11SPIKE:11006133SIGNOR:16140393Cellinker:22353464HPRD:11006133Baccin2019:98194281SPIKE:17537801SPIKE_LC:11006133SPIKE_LC:17537801NetPath:11006133LRdb:9819428Cellinker:11006133 |
| NOTC1 | P46531 | DLL1 | O00548 | Yes | Yes | Yes | WangNetPathHPRDCui2007SignaLink3Baccin2019Ramilowski2015_Baccin2019SPIKE_LCSPIKECellCall | HPRD:11006133Baccin2019:11006133SPIKE:15358736SPIKE_LC:11006133SPIKE_LC:15358736SPIKE:11006133SPIKE_LC:17537801NetPath:11006133SignaLink3:21985982SPIKE:17537801 |
| DLL1 | O00548 | NOTC2 | Q04721 | Yes | Yes | No | iTALKKEGG-MEDICUSICELLNETSIGNORCellPhoneDB_CellinkerUniProt_LRdbCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDCui2007Ramilowski2015_Baccin2019DLRP_talklrWangRamilowski2015CellPhoneDBHPRD_talklrBioGRIDBaccin2019CellinkerSTRING_talklrCellCallCellTalkDBFantom5_LRdbNetPathconnectomeDB2020SPIKE_LCLRdbSPIKE | SIGNOR:23111325Cellinker:10958687NetPath:10958687CellTalkDB:10958687BioGRID:9244302SPIKE:10958687Cellinker:22353464Baccin2019:10958687ICELLNET:21685328LRdb:10958687HPRD:10958687connectomeDB2020:10958687SPIKE_LC:10958687CellChatDB:22353464 |
| NOTC2 | Q04721 | DLL1 | O00548 | Yes | Yes | No | NetPathHPRDCui2007SignaLink3BioGRIDBaccin2019Ramilowski2015_Baccin2019SPIKE_LCSPIKECellCall | Baccin2019:22390640NetPath:10958687BioGRID:9244302SPIKE:10958687SignaLink3:22390640HPRD:10958687SPIKE_LC:10958687 |
| DLL1 | O00548 | NOTC3 | Q9UM47 | Yes | Yes | No | iTALKKEGG-MEDICUSICELLNETSIGNORCellPhoneDB_CellinkerUniProt_LRdbCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDCui2007Wojtowicz2020Ramilowski2015_Baccin2019DLRP_talklrCancerCellMapWangRamilowski2015CellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbNetPathconnectomeDB2020SPIKE_LCLRdbSPIKE | ICELLNET:21685328Cellinker:12482954connectomeDB2020:11006133CellChatDB:22353464connectomeDB2020:12482954LRdb:11LRdb:12482954SPIKE:11006133HPRD:12482954CancerCellMap:11006133Cellinker:22353464HPRD:11006133Baccin2019:11006133Baccin2019:12482954SIGNOR:11006133CellTalkDB:12482954SPIKE_LC:11006133NetPath:11006133Cellinker:11006133 |
| MIB1 | Q86YT6 | DLL1 | O00548 | Yes | Yes | No | KEGG-MEDICUSSIGNORBioGRID | BioGRID:21985982SIGNOR:16140393 |
| LFNG | Q8NES3 | DLL1 | O00548 | Yes | Yes | No | SIGNOR | SIGNOR:11346656 |
Protein Complex Composition
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Delta1 homodimer complex | DLL1 | O00548 | 2 | CORUMPDB | PDB:4xbmCORUM:3270 | 12794186 |
| Gamma-secretase-Delta1 complex | APH1ADLL1NCSTNPSEN1PSENEN | O00548P49768Q92542Q96BI3Q9NZ42 | 1:1:1:1:1 | CompleatCORUM | Compleat:HC2979CORUM:3271 | 12794186 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| 0 |
Sequence, Structure & Domains
Sequences
Length
723
Mass
78,056
Sequence
MGSRCALALAVLSALLCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGAGPPPCACRTFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGGGADSAFSNPIRFPFGFTWPGTFSLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETMNNLANCQREKDISVSIIGATQIKNTNKKADFHGDHSADKNGFKARYPAVDYNLVQDLKGDDTAVRDAHSKRDTKCQPQGSSGEEKGTPTTLRGGEASERKRPDSGCSTSKDTKYQSVYVISEEKDECVIATEV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O00548-1; Sequence=Displayed; Name=2; IsoId=O00548-2; Sequence=VSP_057186, VSP_057187
Alternative Sequence
224..247; PICLPGCDEQHGFCDKPGECKCRV -> RESLGRHRWLTRPRTRTTRRDGAS (in isoform 2); 248..723; Missing (in isoform 2)
3D Structural Models
Turn
322..325; 331..334
Helix
292..295; 408..411
Beta Strand
23..30; 57..66; 78..83; 88..91; 108..112; 118..128; 143..152; 156..166; 169..179; 183..185; 195..197; 200..204; 206..208; 210..212; 216..218; 232..236; 249..254; 265..267; 280..285; 287..289; 303..306; 308..310; 312..315; 342..346; 349..353; 358..362; 365..367; 380..383; 385..387; 389..392; 399..402; 419..422; 427..430
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
653..664; Basic and acidic residues
Domain (FT)
177..221; DSL; 226..254; EGF-like 1; 257..285; EGF-like 2; 292..325; EGF-like 3; 332..363; EGF-like 4; calcium-binding; 370..402; EGF-like 5; 409..440; EGF-like 6; 447..478; EGF-like 7; calcium-binding; 485..516; EGF-like 8
Region
653..702; Disordered; 720..723; Interaction with MAGI1
Clinical Relevance
Drug Targets
Clinical trial targetLiterature-reported target