Protein detail
PODXL
Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1)
Protein symbol PODXL | UniProt ID | EVMP score 0.88 |
Frequency 24 | Transmembrane count 1 | Protein classification Plasma proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1)
Protein Class
Plasma proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Accessory Factors Involved in Transport
Transmembrane
462..482; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
gp135Gp200PCPCLPPDXPODXL1
Gene Description
Podocalyxin like
Chromosome
7
Position
131500262-131558217
Frequency
24
EVMP Score
0.88
Fluorescence & Localization
Tissue Specificadipose tissueBrain Regional SpecificthalamusCell SpecificEndometrial luminal cellsSingle-Nuclei Brain Specifichippocampal CA4Secretome LocationSecreted to bloodSecretome FunctionNo annotated function
Function & Pathway
Protein Function
Transporters:Accessory Factors Involved in Transport
Cellular Component
- GO:0001726 ruffle
- GO:0005615 extracellular space
- GO:0005730 nucleolus
- GO:0005737 cytoplasm
- GO:0005886 plasma membrane
- GO:0016324 apical plasma membrane
- GO:0030027 lamellipodium
- GO:0030175 filopodium
- GO:0031528 microvillus membrane
- GO:0034451 centriolar satellite
- GO:0036057 slit diaphragm
- GO:0043231 intracellular membrane-bounded organelle
- GO:0045121 membrane raft
- GO:0070062 extracellular exosome
Molecular Function
Biological Process
Canonical Pathways
- M5880 Naba ecm affiliated
- M5885 Naba matrisome associated
- M5889 Naba matrisome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
32 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellChatDB | No | Yes | Yes | Yes | No |
| receptor | receptor | OmniPath | No | Yes | Yes | Yes | No |
| ecm | ecm | MatrixDB | Yes | No | Yes | Yes | No |
| ecm | ecm | OmniPath | Yes | No | Yes | Yes | No |
| intracellular | intracellular | ComPPI | No | No | Yes | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | Yes | No |
| intracellular | intracellular | OmniPath | No | No | Yes | Yes | No |
| cell_surface_ligand | cell_surface_ligand | CellPhoneDB | Yes | No | Yes | Yes | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | Yes | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | Yes | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
558
Mass
58,635
Sequence
MRCALALSALLLLLSTPPLLPSSPSPSPSPSQNATQTTTDSSNKTAPTPASSVTIMATDTAQQSTVPTSKANEILASVKATTLGVSSDSPGTTTLAQQVSGPVNTTVARGGGSGNPTTTIESPKSTKSADTTTVATSTATAKPNTTSSQNGAEDTTNSGGKSSHSVTTDLTSTKAEHLTTPHPTSPLSPRQPTSTHPVATPTSSGHDHLMKISSSSSTVAIPGYTFTSPGMTTTLLETVFHHVSQAGLELLTSGDLPTLASQSAGITASSVISQRTQQTSSQMPASSTAPSSQETVQPTSPATALRTPTLPETMSSSPTAASTTHRYPKTPSPTVAHESNWAKCEDLETQTQSEKQLVLNLTGNTLCAGGASDEKLISLICRAVKATFNPAQDKCGIRLASVPGSQTVVVKEITIHTKLPAKDVYERLKDKWDELKEAGVSDMKLGDQGPPEEAEDRFSMPLIITIVCMASFLLLVAALYGCCHQRLSQRKDQQRLTEELQTVENGYHDNPTLEVMETSSEMQEKKVVSLNGELGDSWIVPLDNLTKDDLDEEEDTHL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O00592-1; Sequence=Displayed; Name=2; IsoId=O00592-2; Sequence=VSP_037220
Alternative Sequence
236..268; LETVFHHVSQAGLELLTSGDLPTLASQSAGITA -> P (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
20..29; Pro residues; 32..50; Polar residues; 83..107; Polar residues; 125..142; Low complexity; 143..173; Polar residues; 190..204; Polar residues; 270..302; Polar residues; 313..324; Low complexity
Domain (CC)
Both the O-glycan-rich domain of the extracellular domain and the C-terminus PDZ-binding motif (DTHL) in the cytoplasmic tail harbor an apical sorting signal. The cytoplasmic domain is necessary for the apical membrane targeting and renal tubulogenesis. The cytoplasmic C-terminus PDZ-binding motif (DTHL) is essential for interaction with NHERF1 and for targeting NHERF1 to the apical cell membrane. The extracellular domain is necessary for microvillus formation (By similarity). The large highly anionic extracellular domain allows to maintain open filtration pathways between neighboring podocyte foot processes.
Region
20..50; Disordered; 83..210; Disordered; 270..338; Disordered
Protein Families
Podocalyxin family
Sequence Similarities
Belongs to the podocalyxin family.