Protein detail

F16P2

Fructose-1,6-bisphosphatase isozyme 2 (FBPase 2) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 2) (Muscle FBPase)

Entry name F16P2	UniProt ID O00757	EVMP score 0.38
Frequency 4	Transmembrane count	Protein classification Disease related genesEnzymesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Fructose-1,6-bisphosphatase isozyme 2 (FBPase 2) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 2) (Muscle FBPase)

Protein Class

Disease related genesEnzymesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins
Potential drug targets
Enzymes
ENZYME proteins:Hydrolases
Disease related genes

Ensembl

ENSG00000130957

Entrez Gene Symbol

FBP2

Gene Description

Fructose-bisphosphatase 2

Chromosome

Position

94558720-94593824

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway

Protein Function

Predicted intracellular proteins
Potential drug targets
Enzymes
ENZYME proteins:Hydrolases
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M177 Pid epha fwdpathway

Mediation Categories

Metabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

7 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
IGF2-IGFBP2 complex	IGF2 IGFBP2	P01344 P18065	0:0	CORUM	CORUM:6191	24604839
	FBP2	O00757	4	PDB	PDB:3ifcPDB:5q0cPDB:5et7PDB:3ifaPDB:5et6
	FBP1 FBP2 HMGCS1 IGBP1 ST6GALNAC5 TTR	O00757 P02766 P09467 P78318 Q01581 Q9BVH7	0:0:0:0:0:0	hu.MAP2
	FBP1 FBP2	O00757 P09467	0:0	hu.MAPhu.MAP2
	FBP1 FBP2 ST6GALNAC5	O00757 P09467 Q9BVH7	0:0:0	hu.MAPhu.MAP2
	BMPER COL18A1 CTSF DEFA1B IGFBP2 TKFC	P18065 P39060 P59665 Q3LXA3 Q8N8U9 Q9UBX1	0:0:0:0:0:0	hu.MAP2
	BMPER DEFA1B IGFBP2	P18065 P59665 Q8N8U9	0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blotting	3	31508500 38731868 40098346

Sequence, Structure & Domains

Sequences

Length

339

Mass

36,743

Sequence

MTDRSPFETDMLTLTRYVMEKGRQAKGTGELTQLLNSMLTAIKAISSAVRKAGLAHLYGIAGSVNVTGDEVKKLDVLSNSLVINMVQSSYSTCVLVSEENKDAIITAKEKRGKYVVCFDPLDGSSNIDCLASIGTIFAIYRKTSEDEPSEKDALQCGRNIVAAGYALYGSATLVALSTGQGVDLFMLDPALGEFVLVEKDVKIKKKGKIYSLNEGYAKYFDAATTEYVQKKKFPEDGSAPYGARYVGSMVADVHRTLVYGGIFLYPANQKSPKGKLRLLYECNPVAYIIEQAGGLATTGTQPVLDVKPEAIHQRVPLILGSPEDVQEYLTCVQKNQAGS

3D Structural Models

Turn

51..54; 58..61; 88..90; 127..130; 189..192; 278..281

Helix

14..24; 30..50; 74..87; 108..110; 124..126; 150..153; 157..159; 214..219; 222..232; 249..259; 282..291; 303..305; 322..335

Beta Strand

70..72; 92..97; 111..122; 133..141; 145..147; 161..180; 182..188; 193..201; 208..211; 235..237; 262..265; 268..270; 275..277; 295..297; 299..302; 317..321

3D Structure

X-ray crystallography (14)

Domain & Motif Annotations

Motif

204..208; Nuclear localization signal

Region

3..10; Important for interaction with ALDOA

Protein Families

FBPase class 1 family

Sequence Similarities

Belongs to the FBPase class 1 family.

Clinical Relevance

Disease Involvement

Disease variantLeukodystrophy

Drugs

MB-07803

Antibody

HPA012513 HPA077371

Interaction Protein

ENSG00000165140

Interaction Count

Interaction Dataset

intact_biogrid_bioplex