Protein detail

F16P2

Fructose-1,6-bisphosphatase isozyme 2 (FBPase 2) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 2) (Muscle FBPase)

Entry name F16P2	UniProt ID O00757	EVMP confidence score 0.38
Supporting publications (n) 4	Transmembrane count	Protein classification Disease related genesEnzymesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

Fructose-1,6-bisphosphatase isozyme 2 (FBPase 2) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 2) (Muscle FBPase)

Protein Class (6)

Disease related genesEnzymesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins

Protein Function (5)

Predicted intracellular proteins
Potential drug targets
Enzymes
ENZYME proteins:Hydrolases
Disease related genes

Ensembl

ENSG00000130957

Entrez Gene Symbol

FBP2

Gene Description

Fructose-bisphosphatase 2

Chromosome

Position

94558720-94593824

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway8

Protein Function (5)

Predicted intracellular proteins
Potential drug targets
Enzymes
ENZYME proteins:Hydrolases
Disease related genes

Cellular Component (7)

Molecular Function (4)

Biological Process (3)

KEGG (8)

Reactome (3)

Canonical Pathways

M177 Pid epha fwdpathway

Mediation Categories

Metabolism mediation

Relations & Evidence12

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (7)

7 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
IGF2-IGFBP2 complex	IGF2 IGFBP2	P01344 P18065	0:0	CORUM	CORUM:6191	24604839
	FBP2	O00757	4	PDB	PDB:3ifcPDB:5q0cPDB:5et7PDB:3ifaPDB:5et6
	FBP1 FBP2 HMGCS1 IGBP1 ST6GALNAC5 TTR	O00757 P02766 P09467 P78318 Q01581 Q9BVH7	0:0:0:0:0:0	hu.MAP2
	FBP1 FBP2	O00757 P09467	0:0	hu.MAPhu.MAP2
	FBP1 FBP2 ST6GALNAC5	O00757 P09467 Q9BVH7	0:0:0	hu.MAPhu.MAP2
	BMPER COL18A1 CTSF DEFA1B IGFBP2 TKFC	P18065 P39060 P59665 Q3LXA3 Q8N8U9 Q9UBX1	0:0:0:0:0:0	hu.MAP2
	BMPER DEFA1B IGFBP2	P18065 P59665 Q8N8U9	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blotting	3	31508500 38731868 40098346

Sequence, Structure & Domains11

Sequences

Length

339

Mass

36,743

Sequence

MTDRSPFETDMLTLTRYVMEKGRQAKGTGELTQLLNSMLTAIKAISSAVRKAGLAHLYGIAGSVNVTGDEVKKLDVLSNSLVINMVQSSYSTCVLVSEENKDAIITAKEKRGKYVVCFDPLDGSSNIDCLASIGTIFAIYRKTSEDEPSEKDALQCGRNIVAAGYALYGSATLVALSTGQGVDLFMLDPALGEFVLVEKDVKIKKKGKIYSLNEGYAKYFDAATTEYVQKKKFPEDGSAPYGARYVGSMVADVHRTLVYGGIFLYPANQKSPKGKLRLLYECNPVAYIIEQAGGLATTGTQPVLDVKPEAIHQRVPLILGSPEDVQEYLTCVQKNQAGS

3D Structural Models

Turn

51..54; 58..61; 88..90; 127..130; 189..192; 278..281

Helix

14..24; 30..50; 74..87; 108..110; 124..126; 150..153; 157..159; 214..219; 222..232; 249..259; 282..291; 303..305; 322..335

Beta Strand

70..72; 92..97; 111..122; 133..141; 145..147; 161..180; 182..188; 193..201; 208..211; 235..237; 262..265; 268..270; 275..277; 295..297; 299..302; 317..321

3D Structure

X-ray crystallography (14)

Domain & Motif Annotations

Motif

204..208; Nuclear localization signal

Region

3..10; Important for interaction with ALDOA

Protein Families

FBPase class 1 family

Sequence Similarities

Belongs to the FBPase class 1 family.

Clinical Relevance6

Disease Involvement (2)

Disease variantLeukodystrophy

Drugs

MB-07803

Antibody (2)

HPA012513 HPA077371

Interaction Protein

ENSG00000165140

Interaction Count

Interaction Dataset

intact_biogrid_bioplex

Supporting Publications4

PMID	Title	Abstract
31805958	Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment.	No abstract available
32854315	Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study.	Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD.
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
38716512	Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics.	No abstract available