Protein detail
UBE2C
Ubiquitin-conjugating enzyme E2 C (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme C) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme C) (UbcH10) (Ubiquitin carrier protein C) (Ubiquitin-protein ligase C)
Entry name UBE2C | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Cancer-related genesEnzymesEssential proteinsMetabolic proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Ubiquitin-conjugating enzyme E2 C (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme C) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme C) (UbcH10) (Ubiquitin carrier protein C) (Ubiquitin-protein ligase C)
Protein Class (5)
Cancer-related genesEnzymesEssential proteinsMetabolic proteinsPredicted intracellular proteins
Protein Function (4)
- ENZYME proteins:Transferases
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
UBCH10
Gene Description
Ubiquitin conjugating enzyme E2 C
Chromosome
20
Position
45812576-45816957
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization4
Tissue SpecificintestineCell SpecificEnterocytesSingle-Nuclei Brain Specificastrocyte
Function & Pathway7
Protein Function (4)
- ENZYME proteins:Transferases
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
Cellular Component (6)
Molecular Function (6)
Biological Process (3)
Reactome (34)
- R-hsa-9687136 aberrant regulation of mitotic exit in cancer due to rb1 defects
- R-hsa-176814 activation of apc c and apc c cdc20 mediated degradation of mitotic proteins
- R-hsa-1280218 adaptive immune system
- R-hsa-983168 antigen processing ubiquitination proteasome degradation
- R-hsa-179409 apc cdc20 mediated degradation of nek2a
- R-hsa-174048 apc c cdc20 mediated degradation of cyclin b
- R-hsa-174178 apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1
- R-hsa-174143 apc c mediated degradation of cell cycle proteins
- R-hsa-69017 cdk mediated phosphorylation and removal of cdc6
- R-hsa-8953897 cellular responses to stimuli
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Mediation Categories (3)
Clinical-translation mediationImmune mediationMetabolism mediation
Relations & Evidence21
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (8)
8 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| COMPLEX:P22314_P62979 | UBE2C | O00762 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P22314_P62987 | UBE2C | O00762 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P0CG47_P22314 | UBE2C | O00762 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P0CG48_P22314 | UBE2C | O00762 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:A0AVT1_P0CG47 | UBE2C | O00762 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:A0AVT1_P62979 | UBE2C | O00762 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:A0AVT1_P0CG48 | UBE2C | O00762 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:A0AVT1_P62987 | UBE2C | O00762 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 |
Protein Complex Composition (8)
8 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Ub:E2 | UBBUBE2C | O00762P0CG47 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C497 | |
| Ub:E2 | UBCUBE2C | O00762P0CG48 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C497 | |
| Ub:E2 | RPS27AUBE2C | O00762P62979 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C497 | |
| Ub:E2 | UBA52UBE2C | O00762P62987 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C497 | |
| UBE2C | O00762 | 2 | PDB | PDB:1i7k | ||
| DPYSL2DPYSL5PPIL3UBE2C | O00762Q16555Q9BPU6Q9H2H8 | 0:0:0:0 | hu.MAP2 | |||
| KHSRPUBE2C | O00762Q92945 | 0:0 | hu.MAP2 | |||
| FUBP1UBE2C | O00762Q96AE4 | 0:0 | hu.MAP2 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 30915084 |
Sequence, Structure & Domains13
Sequences
Length
179
Mass
19,652
Sequence
MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKEKWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQEP
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=O00762-1; Sequence=Displayed; Name=2; IsoId=O00762-2; Sequence=VSP_045647; Name=3; IsoId=O00762-3; Sequence=VSP_045648; Name=4; IsoId=O00762-4; Sequence=VSP_045649
Alternative Sequence
1..39; Missing (in isoform 2); 44..72; Missing (in isoform 3); 73..140; VYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKEKWSALYDVRTILLSIQSLLG -> AVGSIRTSSTVCLLSGPRETQDSSKPLVWGLGWDMRLLLELTLQLFLQMP (in isoform 4)
3D Structural Models
Turn
87..91; 119..121
Helix
30..45; 116..118; 128..140; 150..155; 159..172
Beta Strand
50..54; 61..68; 78..84; 95..100; 111..113
3D Structure
Electron microscopy (7); X-ray crystallography (2)
Domain & Motif Annotations
Domain (FT)
30..175; UBC core
Region
1..31; Disordered
Protein Families
Ubiquitin-conjugating enzyme family
Sequence Similarities
Belongs to the ubiquitin-conjugating enzyme family.
Clinical Relevance2
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |