Protein detail
PLPP1
Phospholipid phosphatase 1 (EC 3.1.3.-) (EC 3.1.3.106) (EC 3.1.3.4) (EC 3.6.1.75) (Lipid phosphate phosphohydrolase 1) (PAP2-alpha) (Phosphatidate phosphohydrolase type 2a) (Phosphatidic acid phosphatase 2a) (PAP-2a) (PAP2a)
Entry name PLPP1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 6 | Protein classification EnzymesMetabolic proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Phospholipid phosphatase 1 (EC 3.1.3.-) (EC 3.1.3.106) (EC 3.1.3.4) (EC 3.6.1.75) (Lipid phosphate phosphohydrolase 1) (PAP2-alpha) (Phosphatidate phosphohydrolase type 2a) (Phosphatidic acid phosphatase 2a) (PAP-2a) (PAP2a)
Protein Class
EnzymesMetabolic proteinsPredicted membrane proteins
Protein Function
- Enzymes
- ENZYME proteins:Hydrolases
Transmembrane
7..27; Helical; 54..74; Helical; 95..115; Helical; 165..185; Helical; 200..220; Helical; 230..250; Helical
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Synonym
LPP1PAP-2aPPAP2A
Gene Description
Phospholipid phosphatase 1
Chromosome
5
Position
55424854-55534969
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificliverCell SpecificHepatocytesSingle-Nuclei Brain Specifichippocampal dentate gyrus
Function & Pathway
Protein Function
- Enzymes
- ENZYME proteins:Hydrolases
Cellular Component
Molecular Function
- GO:0000810 diacylglycerol diphosphate phosphatase activity
- GO:0005515 protein binding
- GO:0008195 phosphatidate phosphatase activity
- GO:0042392 sphingosine-1-phosphate phosphatase activity
- GO:0042577 lipid phosphatase activity
- GO:0052642 lysophosphatidic acid phosphatase activity
- GO:0106235 ceramide-1-phosphate phosphatase activity
Biological Process
KEGG
- hsa00561 Glycerolipid metabolism
- KEGG:hsa00564 Glycerophospholipid metabolism
- KEGG:hsa00565 Ether lipid metabolism
- KEGG:hsa00600 Sphingolipid metabolism
- KEGG:hsa01100 Metabolic pathways
- KEGG:hsa04072 Phospholipase D signaling pathway
- KEGG:hsa04666 Fc gamma R-mediated phagosome formation
- KEGG:hsa04975 Fat digestion and absorption
- KEGG:hsa05231 Choline metabolism in cancer
Reactome
Canonical Pathways
- M257 Pid ephrinb rev pathway
- M240 Pid syndecan 2 pathway
- M62 Pid ephb fwd pathway
Mediation Categories
Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_surface_enzyme | cell_surface_enzyme | Surfaceome | Yes | No | No | Yes | No |
| cell_surface_enzyme | cell_surface_enzyme | OmniPath | Yes | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
1 record.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| KIRREL1LSM1LSM2LSM3LSM4LSM6LSM7LSM8MEPCEPLPP1PRPF3PRPF4SART3SNRPD2 | O14494O15116O43172O43395O95777P62310P62312P62316Q15020Q7L2J0Q96J84Q9UK45Q9Y333Q9Y4Z0 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4684 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 36394150 |
Sequence, Structure & Domains
Sequences
Length
284
Mass
32,156
Sequence
MFDKTRLPYVALDVLCVLLAGLPFAILTSRHTPFQRGVFCNDESIKYPYKEDTIPYALLGGIIIPFSIIVIILGETLSVYCNLLHSNSFIRNNYIATIYKAIGTFLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDWSKINCSDGYIEYYICRGNAERVKEGRLSFYSGHSSFSMYCMLFVALYLQARMKGDWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILVAVYVSDFFKERTSFKERKEEDSHTTLHETPTTGNHYPSNHQP
Alternative Products
Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=Alpha-1, hLPP1, PAP2-a1; IsoId=O14494-1; Sequence=Displayed; Name=2; Synonyms=Alpha-2, hLPP1-a, PAP2-a2; IsoId=O14494-2; Sequence=VSP_009651
Alternative Sequence
21..70; GLPFAILTSRHTPFQRGVFCNDESIKYPYKEDTIPYALLGGIIIPFSIIV -> SMPMAVLKLGQIYPFQRGFFCKDNSINYPYHDSTVTSTVLILVGVGLPISS (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
269..284; Polar residues
Motif
5..7; PDZ-binding; involved in localization to the apical cell membrane
Region
120..128; Phosphatase sequence motif I; 168..171; Phosphatase sequence motif II; 216..227; Phosphatase sequence motif III; 260..284; Disordered
Protein Families
PA-phosphatase related phosphoesterase family
Sequence Similarities
Belongs to the PA-phosphatase related phosphoesterase family.