Protein detail

ISLR

Immunoglobulin superfamily containing leucine-rich repeat protein

Entry name ISLR	UniProt ID O14498	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted secreted proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Immunoglobulin superfamily containing leucine-rich repeat protein

Protein Class

Predicted secreted proteins

Protein Function

Predicted secreted proteins

Ensembl

ENSG00000129009

Entrez Gene Symbol

ISLR

Gene Synonym

HsT17563

Gene Description

Immunoglobulin superfamily containing leucine rich repeat

Chromosome

Position

74173710-74176872

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization2

Cell SpecificBreast lactating cells

Function & Pathway5

Protein Function

Predicted secreted proteins

Cellular Component (3)

Biological Process (3)

Reactome (3)

Mediation Categories

Immune mediation

Relations & Evidence14

Ligand-Receptor Signaling (10)

10 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	Yes	No	No
ecm	ecm	OmniPath	Yes	No	Yes	No	No
intracellular	intracellular	GO_Intercell	No	No	Yes	No	No
intracellular	intracellular	OmniPath	No	No	Yes	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	Yes	No	No
transmembrane	transmembrane	OmniPath	No	No	Yes	No	No
secreted	secreted	UniProt_keyword	No	No	Yes	No	No
secreted	secreted	UniProt_location	No	No	Yes	No	No
secreted	secreted	HPA_secretome	No	No	Yes	No	No
secreted	secreted	OmniPath	No	No	Yes	No	No

Protein Complex Composition (3)

3 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
ISLR2-ROCK1 complex	ISLR2 ROCK1	Q13464 Q6UXK2	0:0	CORUM	CORUM:7424	29739947
	CDC6 ISLR SLC10A7 ZRANB3	O14498 Q0GE19 Q5FWF4 Q99741	0:0:0:0	hu.MAP
	CDC6 ISLR	O14498 Q99741	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	27894104

Sequence, Structure & Domains5

Sequences

Length

428

Mass

45,997

Sequence

MQELHLLWWALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVDVALATPGEGGEDTLGRRFHGKAVEGKGCYTVDNEVQPSGPEDNVVIIYLSRAGNPEAAVAEGVPGQLPPGLLLLGQSLLLFFFLTSF

Domain & Motif Annotations

Repeat

51..72; LRR 1; 75..96; LRR 2; 99..122; LRR 3; 123..144; LRR 4; 147..168; LRR 5

Domain (FT)

19..50; LRRNT; 180..231; LRRCT; 232..343; Ig-like

Clinical Relevance1

Antibody (2)

HPA040326 HPA050811

Supporting Publications1

PMID	Title	Abstract
37762473	Pro-Inflammatory Cytokine Priming and Purification Method Modulate the Impact of Exosomes Derived from Equine Bone Marrow Mesenchymal Stromal Cells on Equine Articular Chondrocytes.	Finally, exosomes from MSCs primed with equine pro-inflammatory cytokines (IL-1β, TNF-α, or IFN-γ) further improved the eAC hyaline-like phenotype, particularly IL-1β and TNF-α.