Protein detail

C2C2L

Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24)

Entry name C2C2L	UniProt ID O14523	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24)

Protein Class (3)

Predicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (2)

Predicted intracellular proteins
Transporters:Accessory Factors Involved in Transport

Transmembrane

10..30; Helical

Transmembrane Count

Ensembl

ENSG00000172375

Entrez Gene Symbol

C2CD2L

Gene Synonym (2)

KIAA0285TMEM24

Gene Description

C2CD2 like

Chromosome

Position

119102198-119118544

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue Specificskeletal muscleCell SpecificThymic myoid cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificplasmacytoid DC

Function & Pathway6

Protein Function (2)

Predicted intracellular proteins
Transporters:Accessory Factors Involved in Transport

Cellular Component (5)

Molecular Function (4)

Biological Process (3)

Canonical Pathways

M62 Pid ephb fwd pathway

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence14

Ligand-Receptor Signaling (12)

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	C2CD2L	O14523	6	PDB	PDB:5tod

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	5	31508500 39873726 26801919 33709510 27312428

Sequence, Structure & Domains13

Sequences

Length

706

Mass

76,181

Sequence

MDPGWGQRDVGWAALLILFAASLLTVFAWLLQYARGLWLARARGDRGPGPALAGEPAGSLRELGVWRSLLRLRATRAGAAEEPGVRGLLASLFAFKSFRENWQRAWVRALNEQACRNGSSIQIAFEEVPQLPPRASISHVTCVDQSEHTMVLRCQLSAEEVRFPVSVTQQSPAAVSMETYHVTLTLPPTQLEVNLEEIPGEGLLISWAFTDRPDLSLTVLPKLQARERGEEQVELSTIEELIKDAIVSTQPAMMVNLRACSAPGGLVPSEKPPMMPQAQPAIPRPNRLFLRQLRASHLGNELEGTEELCCVAELDNPMQQKWTKPARAGSEVEWTEDLALDLGPQSRELTLKVLRSSSCGDTELLGQATLPVGSPSRPLSRRQLCPLTPGPGKALGPAATMAVELHYEEGSPRNLGTPTSSTPRPSITPTKKIELDRTIMPDGTIVTTVTTVQSRPRIDGKLDSPSRSPSKVEVTEKTTTVLSESSGPSNTSHSSSRDSHLSNGLDPVAETAIRQLTEPSGRVAKKTPTKRSTLIISGVSKVPIAQDELALSLGYAASLEASVQDDAGTSGGPSSPPSDPPAMSPGPLDALSSPTSVQEADETTRSDISERPSVDDIESETGSTGALETRSLKDHKVSFLRSGTKLIFRRRPRQKEAGLSQSHDDLSNATATPSVRKKAGSFSRRLIKRFSFKSKPKANGNPSPQL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O14523-1; Sequence=Displayed; Name=2; IsoId=O14523-2; Sequence=VSP_021158

Alternative Sequence

497; R -> PG (in isoform 2)

3D Structural Models

Turn

199..201

Helix

91..94; 96..114; 235..248

Beta Strand

122..125; 133..145; 147..171; 174..198; 202..211; 218..221; 252..255

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

417..430; Low complexity; 477..494; Low complexity; 574..584; Pro residues; 602..614; Basic and acidic residues

Domain (CC)

The SMP-LBD domain is a lipid transport module, which binds glycerolipids with a preference for phosphatidylinositol (PI).

Domain (FT)

76..260; SMP-LBD; 268..389; C2

Region

409..430; Disordered; 415..706; Association with the cell membrane; 449..504; Disordered; 564..635; Disordered; 648..682; Disordered

Clinical Relevance4

Antibody (2)

HPA011044 HPA075369

Interaction Protein

ENSG00000012660

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications2

PMID	Title	Abstract
38343172	Analysis of secreted small extracellular vesicles from activated human microglial cell lines reveals distinct pro- and anti-inflammatory proteomic profiles.	No abstract available
40222457	Proteome alterations in peripheral immune cells of DLBCL patients and evidence of cancer extracellular vesicles involvement.	No abstract available