Protein detail

C2C2L

Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24)

Protein symbol
C2C2L
UniProt ID
EVMP score
0.50
Frequency
2
Transmembrane count
1
Protein classification
Predicted intracellular proteinsPredicted membrane proteinsTransporters
Basic Information
Protein Names
Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24)
Protein Class
Predicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
  • Predicted intracellular proteins
  • Transporters:Accessory Factors Involved in Transport
Transmembrane
10..30; Helical
Transmembrane Count
1
Entrez Gene Symbol
Gene Synonym
KIAA0285TMEM24
Gene Description
C2CD2 like
Chromosome
11
Position
119102198-119118544
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificThymic myoid cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificplasmacytoid DC
Function & Pathway
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

12 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo
transmembranetransmembraneUniProt_locationNoNoNoNoNo
transmembranetransmembraneUniProt_topologyNoNoNoNoNo
transmembranetransmembraneUniProt_keywordNoNoNoNoNo
transmembranetransmembraneRamilowski_locationNoNoNoNoNo
transmembranetransmembraneOmniPathNoNoNoNoNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoNoNo
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Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
C2CD2LO145236PDBPDB:5tod

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometry53150850039873726268019193370951027312428
Sequence, Structure & Domains

Sequences

Length
706
Mass
76,181
Sequence
MDPGWGQRDVGWAALLILFAASLLTVFAWLLQYARGLWLARARGDRGPGPALAGEPAGSLRELGVWRSLLRLRATRAGAAEEPGVRGLLASLFAFKSFRENWQRAWVRALNEQACRNGSSIQIAFEEVPQLPPRASISHVTCVDQSEHTMVLRCQLSAEEVRFPVSVTQQSPAAVSMETYHVTLTLPPTQLEVNLEEIPGEGLLISWAFTDRPDLSLTVLPKLQARERGEEQVELSTIEELIKDAIVSTQPAMMVNLRACSAPGGLVPSEKPPMMPQAQPAIPRPNRLFLRQLRASHLGNELEGTEELCCVAELDNPMQQKWTKPARAGSEVEWTEDLALDLGPQSRELTLKVLRSSSCGDTELLGQATLPVGSPSRPLSRRQLCPLTPGPGKALGPAATMAVELHYEEGSPRNLGTPTSSTPRPSITPTKKIELDRTIMPDGTIVTTVTTVQSRPRIDGKLDSPSRSPSKVEVTEKTTTVLSESSGPSNTSHSSSRDSHLSNGLDPVAETAIRQLTEPSGRVAKKTPTKRSTLIISGVSKVPIAQDELALSLGYAASLEASVQDDAGTSGGPSSPPSDPPAMSPGPLDALSSPTSVQEADETTRSDISERPSVDDIESETGSTGALETRSLKDHKVSFLRSGTKLIFRRRPRQKEAGLSQSHDDLSNATATPSVRKKAGSFSRRLIKRFSFKSKPKANGNPSPQL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O14523-1; Sequence=Displayed; Name=2; IsoId=O14523-2; Sequence=VSP_021158
Alternative Sequence
497; R -> PG (in isoform 2)

3D Structural Models

Turn
199..201
Helix
91..94; 96..114; 235..248
Beta Strand
122..125; 133..145; 147..171; 174..198; 202..211; 218..221; 252..255
3D Structure
X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias
417..430; Low complexity; 477..494; Low complexity; 574..584; Pro residues; 602..614; Basic and acidic residues
Domain (CC)
The SMP-LBD domain is a lipid transport module, which binds glycerolipids with a preference for phosphatidylinositol (PI).
Domain (FT)
76..260; SMP-LBD; 268..389; C2
Region
409..430; Disordered; 415..706; Association with the cell membrane; 449..504; Disordered; 564..635; Disordered; 648..682; Disordered
Clinical Relevance
Interaction Protein
ENSG00000012660
Interaction Count
1
Interaction Dataset
intact_biogrid