Protein detail

GP171

G-protein coupled receptor 171 (G-protein coupled receptor H963)

Entry name GP171	UniProt ID O14626	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 7	Protein classification G-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

G-protein coupled receptor 171 (G-protein coupled receptor H963)

Protein Class (3)

G-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins

Protein Function (2)

Predicted intracellular proteins
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

22..42; Helical; Name=1; 49..69; Helical; Name=2; 90..110; Helical; Name=3; 133..153; Helical; Name=4; 182..202; Helical; Name=5; 225..245; Helical; Name=6; 269..289; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000174946

Entrez Gene Symbol

GPR171

Gene Synonym

H963

Gene Description

G protein-coupled receptor 171

Chromosome

Position

151197832-151203216

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization5

Tissue Specificblood vesselCell SpecificB-cellsSingle-Nuclei Brain SpecificleukocyteSecretome LocationSecreted to bloodSecretome FunctionReceptor

Function & Pathway6

Protein Function (2)

Predicted intracellular proteins
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (2)

Molecular Function (5)

Biological Process (3)

Canonical Pathways (2)

M257 Pid ephrinb rev pathway
M62 Pid ephb fwd pathway

Mediation Categories (2)

Immune mediationReceptor-signaling mediation

Relations & Evidence38

Ligand-Receptor Signaling (37)

37 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
gpcr	receptor	DGIdb	No	Yes	No	Yes	No
gpcr	receptor	Almen2009	No	Yes	No	Yes	No
rhodopsin	receptor	Almen2009	No	Yes	No	Yes	No
gpcr	receptor	UniProt_keyword	No	Yes	No	Yes	No
seven_transmembrane_7tm	receptor	HPMR	No	Yes	No	Yes	No
7tm_a	receptor	HPMR	No	Yes	No	Yes	No
cysteinyl_leukotriene_ebv_induced_platelet_activating_factor_7tm_a	receptor	HPMR	No	Yes	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blotting；RNA Sequencing；Flow cytometry；ELISA	1	40730843

Sequence, Structure & Domains5

Sequences

Length

319

Mass

36,754

Sequence

MTNSSFFCPVYKDLEPFTYFFYLVFLVGIIGSCFATWAFIQKNTNHRCVSIYLINLLTADFLLTLALPVKIVVDLGVAPWKLKIFHCQVTACLIYINMYLSIIFLAFVSIDRCLQLTHSCKIYRIQEPGFAKMISTVVWLMVLLIMVPNMMIPIKDIKEKSNVGCMEFKKEFGRNWHLLTNFICVAIFLNFSAIILISNCLVIRQLYRNKDNENYPNVKKALINILLVTTGYIICFVPYHIVRIPYTLSQTEVITDCSTRISLFKAKEATLLLAVSNLCFDPILYYHLSKAFRSKVTETFASPKETKAQKEKLRCENNA

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance1

Antibody

HPA067323

Supporting Publications1

PMID	Title	Abstract
38343172	Analysis of secreted small extracellular vesicles from activated human microglial cell lines reveals distinct pro- and anti-inflammatory proteomic profiles.	No abstract available