Protein detail
GP171
G-protein coupled receptor 171 (G-protein coupled receptor H963)
Entry name GP171 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 7 | Protein classification G-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
G-protein coupled receptor 171 (G-protein coupled receptor H963)
Protein Class (3)
G-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (2)
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
22..42; Helical; Name=1; 49..69; Helical; Name=2; 90..110; Helical; Name=3; 133..153; Helical; Name=4; 182..202; Helical; Name=5; 225..245; Helical; Name=6; 269..289; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
H963
Gene Description
G protein-coupled receptor 171
Chromosome
3
Position
151197832-151203216
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization5
Tissue Specificblood vesselCell SpecificB-cellsSingle-Nuclei Brain SpecificleukocyteSecretome LocationSecreted to bloodSecretome FunctionReceptor
Function & Pathway6
Protein Function (2)
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (2)
Molecular Function (5)
Biological Process (3)
Canonical Pathways (2)
- M257 Pid ephrinb rev pathway
- M62 Pid ephb fwd pathway
Mediation Categories (2)
Immune mediationReceptor-signaling mediation
Relations & Evidence38
Ligand-Receptor Signaling (37)
37 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | scConnect | No | Yes | No | Yes | No |
| receptor | receptor | Almen2009 | No | Yes | No | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | No | Yes | No |
| gpcr | receptor | GPCRdb | No | Yes | No | Yes | No |
| gpcr_orphan | receptor | HGNC | No | Yes | No | Yes | No |
| receptor | receptor | HGNC | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Western blotting；RNA Sequencing；Flow cytometry；ELISA | 1 | 40730843 |
Sequence, Structure & Domains5
Sequences
Length
319
Mass
36,754
Sequence
MTNSSFFCPVYKDLEPFTYFFYLVFLVGIIGSCFATWAFIQKNTNHRCVSIYLINLLTADFLLTLALPVKIVVDLGVAPWKLKIFHCQVTACLIYINMYLSIIFLAFVSIDRCLQLTHSCKIYRIQEPGFAKMISTVVWLMVLLIMVPNMMIPIKDIKEKSNVGCMEFKKEFGRNWHLLTNFICVAIFLNFSAIILISNCLVIRQLYRNKDNENYPNVKKALINILLVTTGYIICFVPYHIVRIPYTLSQTEVITDCSTRISLFKAKEATLLLAVSNLCFDPILYYHLSKAFRSKVTETFASPKETKAQKEKLRCENNA
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance1
Antibody
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 38343172 | Analysis of secreted small extracellular vesicles from activated human microglial cell lines reveals distinct pro- and anti-inflammatory proteomic profiles. | No abstract available |