Protein detail
ENPP3
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (E-NPP 3) (NPP3) (Alkaline phosphodiesterase I) (EC 3.1.4.1) (Dinucleoside polyphosphatase) (EC 3.6.1.-) (Nucleotide diphosphatase) (Nucleotide pyrophosphatase) (NPPase) (EC 3.6.1.9) (Phosphodiesterase I beta) (PD-Ibeta) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (CD antigen CD203c)
Entry name ENPP3 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 6 | Transmembrane count 1 | Protein classification CD markersEnzymesMetabolic proteinsPredicted intracellular proteinsPredicted secreted proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (E-NPP 3) (NPP3) (Alkaline phosphodiesterase I) (EC 3.1.4.1) (Dinucleoside polyphosphatase) (EC 3.6.1.-) (Nucleotide diphosphatase) (Nucleotide pyrophosphatase) (NPPase) (EC 3.6.1.9) (Phosphodiesterase I beta) (PD-Ibeta) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (CD antigen CD203c)
Protein Class (5)
CD markersEnzymesMetabolic proteinsPredicted intracellular proteinsPredicted secreted proteins
Protein Function (5)
- Predicted intracellular proteins
- CD markers
- Enzymes
- Predicted secreted proteins
- ENZYME proteins:Hydrolases
Transmembrane
12..30; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
B10CD203cgp130RB13-6PD-IBETAPDNP3
Gene Description
Ectonucleotide pyrophosphatase/phosphodiesterase 3
Chromosome
6
Position
131628442-131747418
Supporting publications (n)
6
EVMP confidence score
0.38
Fluorescence & Localization3
Tissue Specificbone marrowCell SpecificBrain excitatory neuronsBlood Cell Specificmemory B-cell
Function & Pathway7
Protein Function (5)
- Predicted intracellular proteins
- CD markers
- Enzymes
- Predicted secreted proteins
- ENZYME proteins:Hydrolases
Cellular Component (5)
Molecular Function (11)
- GO:0003676 nucleic acid binding
- GO:0004081 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
- GO:0004528 phosphodiesterase I activity
- GO:0005509 calcium ion binding
- GO:0008270 zinc ion binding
- GO:0034432 bis(5'-adenosyl)-pentaphosphatase activity
- GO:0036219 GTP diphosphatase activity
- GO:0036221 UTP diphosphatase activity
- GO:0047429 nucleoside triphosphate diphosphatase activity
- GO:0047693 ATP diphosphatase activity
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Biological Process (3)
KEGG (8)
- hsa00230 Purine metabolism
- KEGG:hsa00240 Pyrimidine metabolism
- KEGG:hsa00500 Starch and sucrose metabolism
- KEGG:hsa00740 Riboflavin metabolism
- KEGG:hsa00760 Nicotinate and nicotinamide metabolism
- KEGG:hsa00770 Pantothenate and CoA biosynthesis
- KEGG:hsa01100 Metabolic pathways
- KEGG:hsa01232 Nucleotide metabolism
Reactome (3)
Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence31
Ligand-Receptor Signaling (29)
29 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | DGIdb | No | No | Yes | Yes | No |
| extracellular | extracellular | OmniPath | No | No | Yes | Yes | No |
| intracellular | intracellular | ComPPI | No | No | Yes | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | Yes | No |
| intracellular | intracellular | OmniPath | No | No | Yes | Yes | No |
| ectonucleotide_phosphatase | cell_surface_enzyme | HGNC | Yes | No | Yes | Yes | No |
| cell_surface_enzyme | cell_surface_enzyme | HGNC | Yes | No | Yes | Yes | No |
| cell_surface_enzyme | cell_surface_enzyme | OmniPath | Yes | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | Yes | Yes | No |
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Protein Complex Composition (1)
Sequence, Structure & Domains12
Sequences
Length
875
Mass
100,124
Sequence
MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI
3D Structural Models
Turn
100..104; 139..141; 231..234; 272..275; 362..364; 411..417; 427..429; 536..539; 636..639
Helix
66..68; 75..78; 85..89; 91..93; 119..122; 129..132; 149..151; 171..176; 178..180; 182..190; 205..214; 218..221; 242..245; 247..249; 255..261; 295..306; 310..312; 325..331; 336..358; 386..388; 420..426; 441..443; 446..448; 490..492; 514..516; 517..525; 540..542; 578..580; 583..591; 597..607; 673..675; 679..684; 696..698; 704..708; 711..713; 719..730; 732..739; 762..764; 815..817; 824..826; 828..834; 839..846; 858..866
Beta Strand
112..114; 161..166; 191..195; 225..230; 235..237; 266..270; 284..286; 315..321; 333..335; 366..370; 382..385; 396..399; 401..403; 405..410; 435..440; 458..463; 468..472; 479..482; 496..500; 505..509; 543..545; 617..619; 622..626; 631..635; 640..648; 689..694; 700..703; 714..717; 742..750; 756..758; 778..789; 801..809; 847..849
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Motif
78..80; Cell attachment site
Domain (FT)
50..93; SMB 1; 94..138; SMB 2
Region
160..545; Phosphodiesterase; 582..875; Nuclease
Protein Families
Nucleotide pyrophosphatase/phosphodiesterase family
Sequence Similarities
Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
Clinical Relevance4
Related Diseases
Biomarker
Phase 2
Antibody
Supporting Publications6
| PMID | Title | Abstract |
|---|---|---|
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No abstract available |
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No abstract available |
| 34817906 | Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform. | No abstract available |
| 37786918 | Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples. | No abstract available |
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No abstract available |
| 39948040 | Quantitative proteomics identifies possible flow of metastatic cues between progressive stages of colorectal cancer via transfer of ceramide-dependent exosomal cargoes. | No abstract available |