EV MemProt Atlas

Basic Information

Protein Names

Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)

Protein Class

Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function

Disease related genes
Human disease related genes:Congenital malformations:Other congenital malformations
Predicted intracellular proteins

Ensembl

ENSG00000107404

Entrez Gene Symbol

DVL1

Gene Description

Dishevelled segment polarity protein 1

Chromosome

1

Position

1335276-1349418

Frequency

1

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificbone marrowCell SpecificCytotrophoblasts

Function & Pathway

Protein Function

Disease related genes
Human disease related genes:Congenital malformations:Other congenital malformations
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M214 Pid erbb1 internalization pathway

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
DVL1	CSNK1E	P49674	S	142	phosphorylation	SIGNOR_ProtMapperSIGNORProtMapper	SIGNOR:16965538 ProtMapper:16965538
DVL1	CSNK1E	P49674	S	139	phosphorylation	SIGNOR_ProtMapperSIGNORProtMapper	SIGNOR:16965538 ProtMapper:16965538

Ligand-Receptor Signaling

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network

38 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
DVL1	O14640	DAAM1	Q9Y4D1	Yes	Yes	No	WangSIGNORHPRDSignaLink3SPIKE_LCSPIKE	SignaLink3:20006983 SIGNOR:19365405 HPRD:11779461 SignaLink3:23331499 SPIKE:11779461 SPIKE_LC:11779461
INVS	Q9Y283	DVL1	O14640	Yes	Yes	Yes	SPIKESPIKE_LCSIGNORSignaLink3	SignaLink3:20006983 SPIKE:15852005 SIGNOR:15852005 SPIKE_LC:20798123 SPIKE_LC:15852005 SPIKE:20798123 SignaLink3:23331499
KC1E	P49674	DVL1	O14640	Yes	Yes	Yes	WangNetPathiPTMnetPhosphoPointSIGNORProtMapperHPRDCui2007SignaLink3IntActSIGNOR_ProtMapperSPIKESPIKE_LC	SIGNOR:16965538 SPIKE_LC:14966280 SPIKE_LC:21285348 SignaLink3:20006983 HPRD:11818547 SPIKE:14966280 IntAct:11425858 SPIKE:20215527 SPIKE_LC:20215527 NetPath:14966280 HPRD:11487578 SignaLink3:23331499 ProtMapper:16965538 SPIKE:21285348
DVL1	O14640	RAC1	P63000	Yes	Yes	No	WangNetPathSIGNORHPRDSignaLink3SPIKE_LCSPIKE	HPRD:12533515 SPIKE_LC:12533515 NetPath:12533515 SIGNOR:19365405 SPIKE:15608632 SPIKE:12533515 SignaLink3:23331499 SPIKE:17363564 SPIKE_LC:15608632 SPIKE_LC:17363564 SignaLink3:12533515
KLH12	Q53G59	DVL1	O14640	Yes	No	Yes	SIGNORELMHINTSPIKE_LCSPIKE	SIGNOR:16547521 SPIKE:20970343 ELM:32574548 HINT:32574548 SPIKE_LC:20970343
SDC4	P31431	DVL1	O14640	Yes	Yes	No	SPIKESPIKE_LCSIGNOR	SPIKE_LC:18403410 SIGNOR:23151663 SPIKE:16604063 SPIKE:18403410 SPIKE_LC:16604063
ARRB1	P49407	DVL1	O14640	Yes	Yes	No	WangNetPathHPRDCui2007SignaLink3SPIKE_LCSPIKE	SPIKE_LC:20223821 NetPath:11742073 SPIKE:20223821 HPRD:11742073 SPIKE_LC:11742073 SignaLink3:23331499 SPIKE:11742073 SignaLink3:11742073
SMAD1	Q15797	DVL1	O14640	Yes	Yes	No	NetPathSIGNORSignaLink3SPIKE_LCSPIKE	SPIKE:12650946 SPIKE:16621789 SPIKE_LC:16621789 SignaLink3:16621789 NetPath:16621789 SIGNOR:16621789 SignaLink3:23331499 SPIKE_LC:12650946
DVL1	O14640	SMAD3	P84022	Yes	Yes	No	WangNetPathHPRDCui2007SignaLink3SPIKE_LCSPIKE	SignaLink3:12650946 SPIKE:12650946 HPRD:12650946 NetPath:15888125 SignaLink3:23331499 SPIKE:15955531 SPIKE_LC:15955531 SPIKE_LC:12650946
RYK	P34925	DVL1	O14640	Yes	Yes	No	SPIKESPIKE_LCSIGNORSignaLink3	SignaLink3:15454084 SPIKE_LC:15454084 SignaLink3:23331499 SPIKE:15454084 SIGNOR:15454084

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Protein Complex Composition

16 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Axin-Dvl-Gsk complex	AXIN1 DVL1 DVL2 DVL3 GSK3A GSK3B	O14640 O14641 O15169 P49840 P49841 Q92997	1:1:1:1:1:1	Compleat	Compleat:HC2256	10428961
Ccd1-Dvl2 complex	DIXDC1 DVL1 DVL2 DVL3	O14640 O14641 Q155Q3 Q92997	1:1:1:1	Compleat	Compleat:HC3284	15262978
Ccd1-Dvl2-Rac complex	DIXDC1 DVL1 DVL2 DVL3 RAC1 RAC3	O14640 O14641 P60763 P63000 Q155Q3 Q92997	1:1:1:1:1:1	Compleat	Compleat:HC2839	15262978
Dvl2-Rac complex	DVL1 DVL2 DVL3 RAC1 RAC3	O14640 O14641 P60763 P63000 Q92997	1:1:1:1:1	Compleat	Compleat:HC2761	15262978
Quaternary complex (DvlGsk3bFrat1Axin1)	AXIN1 DVL1 DVL2 DVL3 FRAT1 GSK3A GSK3B	O14640 O14641 O15169 P49840 P49841 Q92837 Q92997	1:1:1:1:1:1:1	Compleat	Compleat:HC1124	10428961
Ryk-Dvl1 complex	DVL1 DVL2 DVL3 RYK	O14640 O14641 P34925 Q92997	1:1:1:1	Compleat	Compleat:HC842	15454084
TSC2-DVL complex	DVL1 TSC2	O14640 P49815	0:0	CORUM	CORUM:7158	15972957
TSC2-GSK3-AXIN-DVL complex	AXIN1 DVL1 GSK3B TSC2	O14640 O15169 P49815 P49841	0:0:0:0	CORUM	CORUM:7159	15972957
Ternary complex (CCD1DvlRac)	AKT1 AKT2 AKT3 DIXDC1 DVL1 DVL2 DVL3	O14640 O14641 P31749 P31751 Q155Q3 Q92997 Q9Y243	1:1:1:1:1:1:1	Compleat	Compleat:HC2686	15262978
	DVL1	O14640	8	PDB	PDB:6lca

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	5	40189497 38113368 37322475 38207106 37926756

Sequence, Structure & Domains

Sequences

Length

695

Mass

75,187

Sequence

MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSFHPNVASSRDGMDNETGTESMVSHRRERARRRNREEAARTNGHPRGDRRRDVGLPPDSASTALSSELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDSTMSLNIVTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPIDPAAWLSHTAALTGALPRYGTSPCSSAVTRTSSSSLTSSVPGAPQLEEAPLTVKSDMSAVVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSLLKHGFLRHTVNKITFSEQCYYVFGDLCSNLATLNLNSGSSGTSDQDTLAPLPHPAAPWPLGQGYPYQYPGPPPCFPPAYQDPGFSYGSGSTGSQQSEGSKSSGSTRSSRRAPGREKERRAAGAGGSGSESDHTAPSGVGSSWRERPAGQLSRGSSPRSQASATAPGLPPPHPTTKAYTVVGGPPGGPPVRELAAVPPELTGSRQSFQKAMGNPCEFFVDIM

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O14640-1; Sequence=Displayed; Name=2; IsoId=O14640-2; Sequence=VSP_024460

Alternative Sequence

378..403; GTSPCSSAVTRTSSSSLTSSVPGAPQ -> E (in isoform 2)

3D Structural Models

Helix

288..292; 314..326

Beta Strand

249..254; 264..267; 279..283; 300..304; 327..329; 331..336

3D Structure

X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias

142..151; Basic residues; 152..171; Basic and acidic residues; 176..192; Low complexity; 200..214; Low complexity; 215..228; Basic residues; 551..580; Low complexity; 625..636; Polar residues

Domain (CC)

The DIX domain promotes homooligomerization.; DOMAIN: The DEP domain mediates interaction with the cell membrane.

Domain (FT)

1..85; DIX; 251..323; PDZ; 425..499; DEP

Region

89..237; Disordered; 543..667; Disordered

Protein Families

DSH family

Sequence Similarities

Belongs to the DSH family.

Clinical Relevance

Disease Involvement

Dwarfism

Drugs

ILLUDALIC ACID

Antibody

CAB011538 HPA073607

Interaction Protein

ENSG00000004975ENSG00000018408ENSG00000161202

Interaction Count

3

Interaction Dataset

intact_biogrid

Protein symbol DVL1	UniProt ID O14640	EVMP score 0.50
Frequency 1	Transmembrane count	Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins