Protein detail

DVL1

Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)

Entry name DVL1	UniProt ID O14640	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)

Protein Class (4)

Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (3)

Disease related genes
Human disease related genes:Congenital malformations:Other congenital malformations
Predicted intracellular proteins

Ensembl

ENSG00000107404

Entrez Gene Symbol

DVL1

Gene Description

Dishevelled segment polarity protein 1

Chromosome

Position

1335276-1349418

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue Specificbone marrowCell SpecificCytotrophoblasts

Function & Pathway8

Protein Function (3)

Disease related genes
Human disease related genes:Congenital malformations:Other congenital malformations
Predicted intracellular proteins

Cellular Component (16)

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Molecular Function (7)

Biological Process (3)

KEGG (16)

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Reactome (14)

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Canonical Pathways

M214 Pid erbb1 internalization pathway

Mediation Categories (3)

Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence64

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
DVL1	CSNK1E	P49674	S	142	phosphorylation	SIGNOR_ProtMapperSIGNORProtMapper	SIGNOR:16965538 ProtMapper:16965538
DVL1	CSNK1E	P49674	S	139	phosphorylation	SIGNOR_ProtMapperSIGNORProtMapper	SIGNOR:16965538 ProtMapper:16965538

Ligand-Receptor Signaling (7)

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network (38)

38 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
DVL1	O14640	LRRK2	Q5S007	Yes	Yes	No	SPIKE_LCLit-BM-17SPIKESignaLink3	SignaLink3:20006983 Lit-BM-17:19625296 SignaLink3:23331499 SPIKE_LC:19625296 SPIKE:19625296
DVL1	O14640	AXIN1	O15169	Yes	No	Yes	WangNetPathSIGNORHPRDCui2007BioGRIDCA1SPIKE_LCSPIKE	SPIKE_LC:11278246 HPRD:12556519 CA1:11027605 SIGNOR:10196136 SPIKE_LC:10428961 SPIKE:11278246 HPRD:9482734 NetPath:11278246 CA1:10330181 CA1:10862053 SPIKE:18339531 SPIKE_LC:9482734 BioGRID:10428961 SPIKE:10428961 SPIKE:9482734 SPIKE_LC:18339531 HPRD:10330403 NetPath:10428961
HECW1	Q76N89	DVL1	O14640	Yes	No	Yes	SPIKEHPRDSPIKE_LCSIGNOR	HPRD:14684739 SPIKE_LC:14684739 SPIKE_LC:16713569 SPIKE:14684739 SIGNOR:14684739 SPIKE:16713569
DIXC1	Q155Q3	DVL1	O14640	Yes	Yes	No	SPIKE_LCSPIKESignaLink3	SPIKE:12526749 SPIKE_LC:15262978 SignaLink3:21189423 SPIKE:15262978 SPIKE_LC:12526749
ANC2	Q9UJX6	DVL1	O14640	Yes	No	Yes	SPIKESPIKE_LCSIGNOR	SPIKE:19805045 SPIKE_LC:19805045 SIGNOR:19805045
DVL1	O14640	P4K2B	Q8TCG2	Yes	Yes	No	SignaLink3	SignaLink3:23331499 SignaLink3:19561074
KC1D	P48730	DVL1	O14640	Yes	Yes	No	PhosphoPointHPRDSignaLink3ACSNWang	HPRD:11818547 ACSN:21316585 SignaLink3:23331499 SignaLink3:11818547
DVL1	O14640	CTNB1	P35222	Yes	Yes	Yes	SIGNORHPRDSignaLink3WangLit-BM-17	SignaLink3:20006983 Lit-BM-17:25241761 SignaLink3:10806215 HPRD:10806215 SIGNOR:15735151 SignaLink3:23331499 Lit-BM-17:10806215
DVL1	O14640	JUN	P05412	Yes	Yes	No	SIGNORSignaLink3	SIGNOR:18347071 SignaLink3:20006983 SignaLink3:23331499
DVL1	O14640	ROCK1	Q13464	Yes	Yes	No	SignaLink3	SignaLink3:15121866 SignaLink3:23331499

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Protein Complex Composition (16)

16 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
DVL1 DVL2	O14640 O14641	0:0	hu.MAPhu.MAP2
ATN1 AXIN1 CSNK1E DVL1 DVL2 DVL3	O14640 O14641 O15169 P49674 P54259 Q92997	1:1:1:1:1:1	CompleatCFinder	Compleat:HC5105
DVL1 DVL2 NXF2B STOX2	O14640 O14641 Q9GZY0 Q9P2F5	0:0:0:0	hu.MAP2
DVL1 FRAT2	O14640 O75474	0:0	KEGG-MEDICUS
DVL1 KLHL12	O14640 Q53G59	4:4	PDB	PDB:6ttk
DVL1 FRAT1	O14640 Q92837	0:0	KEGG-MEDICUS

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	5	40189497 38113368 37322475 38207106 37926756

Sequence, Structure & Domains14

Sequences

Length

695

Mass

75,187

Sequence

MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSFHPNVASSRDGMDNETGTESMVSHRRERARRRNREEAARTNGHPRGDRRRDVGLPPDSASTALSSELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDSTMSLNIVTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPIDPAAWLSHTAALTGALPRYGTSPCSSAVTRTSSSSLTSSVPGAPQLEEAPLTVKSDMSAVVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSLLKHGFLRHTVNKITFSEQCYYVFGDLCSNLATLNLNSGSSGTSDQDTLAPLPHPAAPWPLGQGYPYQYPGPPPCFPPAYQDPGFSYGSGSTGSQQSEGSKSSGSTRSSRRAPGREKERRAAGAGGSGSESDHTAPSGVGSSWRERPAGQLSRGSSPRSQASATAPGLPPPHPTTKAYTVVGGPPGGPPVRELAAVPPELTGSRQSFQKAMGNPCEFFVDIM

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O14640-1; Sequence=Displayed; Name=2; IsoId=O14640-2; Sequence=VSP_024460

Alternative Sequence

378..403; GTSPCSSAVTRTSSSSLTSSVPGAPQ -> E (in isoform 2)

3D Structural Models

Helix

288..292; 314..326

Beta Strand

249..254; 264..267; 279..283; 300..304; 327..329; 331..336

3D Structure

X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias

142..151; Basic residues; 152..171; Basic and acidic residues; 176..192; Low complexity; 200..214; Low complexity; 215..228; Basic residues; 551..580; Low complexity; 625..636; Polar residues

Domain (CC)

The DIX domain promotes homooligomerization.; DOMAIN: The DEP domain mediates interaction with the cell membrane.

Domain (FT)

1..85; DIX; 251..323; PDZ; 425..499; DEP

Region

89..237; Disordered; 543..667; Disordered

Protein Families

DSH family

Sequence Similarities

Belongs to the DSH family.

Clinical Relevance6

Disease Involvement

Dwarfism

Drugs

ILLUDALIC ACID

Antibody (2)

CAB011538 HPA073607

Interaction Protein (3)

ENSG00000004975ENSG00000018408ENSG00000161202

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available