Protein detail
DVL1
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
Protein symbol DVL1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
Protein Class
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Description
Dishevelled segment polarity protein 1
Chromosome
1
Position
1335276-1349418
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificCytotrophoblasts
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
- Predicted intracellular proteins
Cellular Component
- GO:0005829 cytosol
- GO:0005874 microtubule
- GO:0014069 postsynaptic density
- GO:0016328 lateral plasma membrane
- GO:0030136 clathrin-coated vesicle
- GO:0030426 growth cone
- GO:0031410 cytoplasmic vesicle
- GO:0043005 neuron projection
- GO:0043025 neuronal cell body
- GO:0043197 dendritic spine
- GO:0045202 synapse
- GO:0098685 Schaffer collateral - CA1 synapse
- GO:0098793 presynapse
- GO:0098978 glutamatergic synapse
- GO:0098992 neuronal dense core vesicle
- GO:1990909 Wnt signalosome
Molecular Function
Biological Process
KEGG
- hsa04150 mTOR signaling pathway
- KEGG:hsa04310 Wnt signaling pathway
- KEGG:hsa04330 Notch signaling pathway
- KEGG:hsa04390 Hippo signaling pathway
- KEGG:hsa04519 Cadherin signaling
- KEGG:hsa04550 Signaling pathways regulating pluripotency of stem cells
- KEGG:hsa04916 Melanogenesis
- KEGG:hsa04934 Cushing syndrome
- KEGG:hsa05010 Alzheimer disease
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05165 Human papillomavirus infection
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05217 Basal cell carcinoma
- KEGG:hsa05224 Breast cancer
- KEGG:hsa05225 Hepatocellular carcinoma
- KEGG:hsa05226 Gastric cancer
Reactome
- R-hsa-3858494 beta catenin independent wnt signaling
- R-hsa-4641258 degradation of dvl
- R-hsa-4641262 disassembly of the destruction complex and recruitment of axin to the membrane
- R-hsa-5663205 infectious disease
- R-hsa-9664420 killing mechanisms
- R-hsa-9658195 leishmania infection
- R-hsa-5368598 negative regulation of tcf dependent signaling by dvl interacting proteins
- R-hsa-4086400 pcp ce pathway
- R-hsa-5663220 rho gtpases activate formins
- R-hsa-195258 rho gtpase effectors
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-195721 signaling by wnt
- R-hsa-201681 tcf dependent signaling in response to wnt
- R-hsa-201688 wnt mediated activation of dvl
Canonical Pathways
M214 Pid erbb1 internalization pathway
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| DVL1 | CSNK1E | P49674 | S | 142 | phosphorylation | SIGNOR_ProtMapperSIGNORProtMapper | SIGNOR:16965538ProtMapper:16965538 |
| DVL1 | CSNK1E | P49674 | S | 139 | phosphorylation | SIGNOR_ProtMapperSIGNORProtMapper | SIGNOR:16965538ProtMapper:16965538 |
Ligand-Receptor Signaling
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
38 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| COMPLEX:P62877_P63208_Q13618 | DVL1 | O14640 | Yes | No | Yes | SIGNOR | SIGNOR:16547521 | |
| LRP5 | O75197 | DVL1 | O14640 | Yes | Yes | No | SIGNOR | SIGNOR:23209147 |
| YAP1 | P46937 | DVL1 | O14640 | Yes | No | Yes | SIGNOR | SIGNOR:23178811 |
| FZD7 | O75084 | DVL1 | O14640 | Yes | Yes | No | ELMWangSIGNOR | ELM:14636582ELM:19388021SIGNOR:22179044 |
| DVL1 | O14640 | PLCB1 | Q9NQ66 | Yes | Yes | No | SIGNOR | SIGNOR:19279717 |
| DVL1 | O14640 | APC | P25054 | Yes | No | Yes | WangHINTSIGNORIntAct | IntAct:20224554HINT:11425858SIGNOR:10330181HINT:20224554 |
| DVL1 | O14640 | RHOA | P61586 | Yes | Yes | No | WangSIGNOR | SIGNOR:27571105 |
| FZD1 | Q9UP38 | DVL1 | O14640 | Yes | Yes | No | WangSIGNOR | SIGNOR:22944199 |
| DVL1 | O14640 | LRP6 | O75581 | Yes | Yes | No | WangSIGNOR | SIGNOR:17569865 |
| LRP6 | O75581 | DVL1 | O14640 | Yes | Yes | No | WangSIGNOR | SIGNOR:23209147 |
Protein Complex Composition
16 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Axin-Dvl-Gsk complex | AXIN1DVL1DVL2DVL3GSK3AGSK3B | O14640O14641O15169P49840P49841Q92997 | 1:1:1:1:1:1 | Compleat | Compleat:HC2256 | 10428961 |
| Ccd1-Dvl2 complex | DIXDC1DVL1DVL2DVL3 | O14640O14641Q155Q3Q92997 | 1:1:1:1 | Compleat | Compleat:HC3284 | 15262978 |
| Ccd1-Dvl2-Rac complex | DIXDC1DVL1DVL2DVL3RAC1RAC3 | O14640O14641P60763P63000Q155Q3Q92997 | 1:1:1:1:1:1 | Compleat | Compleat:HC2839 | 15262978 |
| Dvl2-Rac complex | DVL1DVL2DVL3RAC1RAC3 | O14640O14641P60763P63000Q92997 | 1:1:1:1:1 | Compleat | Compleat:HC2761 | 15262978 |
| Quaternary complex (DvlGsk3bFrat1Axin1) | AXIN1DVL1DVL2DVL3FRAT1GSK3AGSK3B | O14640O14641O15169P49840P49841Q92837Q92997 | 1:1:1:1:1:1:1 | Compleat | Compleat:HC1124 | 10428961 |
| Ryk-Dvl1 complex | DVL1DVL2DVL3RYK | O14640O14641P34925Q92997 | 1:1:1:1 | Compleat | Compleat:HC842 | 15454084 |
| TSC2-DVL complex | DVL1TSC2 | O14640P49815 | 0:0 | CORUM | CORUM:7158 | 15972957 |
| TSC2-GSK3-AXIN-DVL complex | AXIN1DVL1GSK3BTSC2 | O14640O15169P49815P49841 | 0:0:0:0 | CORUM | CORUM:7159 | 15972957 |
| Ternary complex (CCD1DvlRac) | AKT1AKT2AKT3DIXDC1DVL1DVL2DVL3 | O14640O14641P31749P31751Q155Q3Q92997Q9Y243 | 1:1:1:1:1:1:1 | Compleat | Compleat:HC2686 | 15262978 |
| DVL1 | O14640 | 8 | PDB | PDB:6lca |
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Sequence, Structure & Domains
Sequences
Length
695
Mass
75,187
Sequence
MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSFHPNVASSRDGMDNETGTESMVSHRRERARRRNREEAARTNGHPRGDRRRDVGLPPDSASTALSSELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDSTMSLNIVTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPIDPAAWLSHTAALTGALPRYGTSPCSSAVTRTSSSSLTSSVPGAPQLEEAPLTVKSDMSAVVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSLLKHGFLRHTVNKITFSEQCYYVFGDLCSNLATLNLNSGSSGTSDQDTLAPLPHPAAPWPLGQGYPYQYPGPPPCFPPAYQDPGFSYGSGSTGSQQSEGSKSSGSTRSSRRAPGREKERRAAGAGGSGSESDHTAPSGVGSSWRERPAGQLSRGSSPRSQASATAPGLPPPHPTTKAYTVVGGPPGGPPVRELAAVPPELTGSRQSFQKAMGNPCEFFVDIM
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O14640-1; Sequence=Displayed; Name=2; IsoId=O14640-2; Sequence=VSP_024460
Alternative Sequence
378..403; GTSPCSSAVTRTSSSSLTSSVPGAPQ -> E (in isoform 2)
3D Structural Models
Helix
288..292; 314..326
Beta Strand
249..254; 264..267; 279..283; 300..304; 327..329; 331..336
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
142..151; Basic residues; 152..171; Basic and acidic residues; 176..192; Low complexity; 200..214; Low complexity; 215..228; Basic residues; 551..580; Low complexity; 625..636; Polar residues
Domain (CC)
The DIX domain promotes homooligomerization.; DOMAIN: The DEP domain mediates interaction with the cell membrane.
Domain (FT)
1..85; DIX; 251..323; PDZ; 425..499; DEP
Region
89..237; Disordered; 543..667; Disordered
Protein Families
DSH family
Sequence Similarities
Belongs to the DSH family.
Clinical Relevance
Disease Involvement
Dwarfism
Drugs
Interaction Protein
ENSG00000004975ENSG00000018408ENSG00000161202
Interaction Count
3
Interaction Dataset
intact_biogrid