Protein detail
ADA10
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (CDw156) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c)
Protein symbol ADA10 | UniProt ID | EVMP score 0.63 |
Frequency 8 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersDisease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (CDw156) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c)
Protein Class
Cancer-related genesCD markersDisease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- CD markers
- Potential drug targets
- Enzymes
- ENZYME proteins:Hydrolases
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
Transmembrane
673..693; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD156CHsT18717kuzMADM
Gene Description
ADAM metallopeptidase domain 10
Chromosome
15
Position
58588809-58749791
Frequency
8
EVMP Score
0.63
Fluorescence & Localization
Function & Pathway
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- CD markers
- Potential drug targets
- Enzymes
- ENZYME proteins:Hydrolases
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
Cellular Component
- GO:0000139 Golgi membrane
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005788 endoplasmic reticulum lumen
- GO:0005794 Golgi apparatus
- GO:0005798 Golgi-associated vesicle
- GO:0005886 plasma membrane
- GO:0005912 adherens junction
- GO:0005925 focal adhesion
- GO:0009986 cell surface
- GO:0014069 postsynaptic density
- GO:0016020 membrane
- GO:0030136 clathrin-coated vesicle
- GO:0030424 axon
- GO:0030425 dendrite
- GO:0035579 specific granule membrane
- GO:0043231 intracellular membrane-bounded organelle
- GO:0046930 pore complex
- GO:0070062 extracellular exosome
- GO:0070821 tertiary granule membrane
- GO:0097038 perinuclear endoplasmic reticulum
- GO:0097060 synaptic membrane
- GO:0097197 tetraspanin-enriched microdomain
- GO:0098978 glutamatergic synapse
Molecular Function
- GO:0004175 endopeptidase activity
- GO:0004222 metalloendopeptidase activity
- GO:0005102 signaling receptor binding
- GO:0005178 integrin binding
- GO:0005515 protein binding
- GO:0008237 metallopeptidase activity
- GO:0017124 SH3 domain binding
- GO:0019901 protein kinase binding
- GO:0042803 protein homodimerization activity
- GO:0046872 metal ion binding
- GO:0070573 metallodipeptidase activity
- GO:1902945 metalloendopeptidase activity involved in amyloid precursor protein catabolic process
Biological Process
KEGG
Reactome
- R-hsa-2122948 activated notch1 transmits signal to the nucleus
- R-hsa-977225 amyloid fiber formation
- R-hsa-1442490 collagen degradation
- R-hsa-1474228 degradation of the extracellular matrix
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-3928665 eph ephrin mediated repulsion of cells
- R-hsa-2682334 eph ephrin signaling
- R-hsa-1474244 extracellular matrix organization
- R-hsa-168249 innate immune system
- R-hsa-9675108 nervous system development
- R-hsa-6798695 neutrophil degranulation
- R-hsa-2979096 notch2 activation and transmission of signal to the nucleus
- R-hsa-9013507 notch3 activation and transmission of signal to the nucleus
- R-hsa-9013700 notch4 activation and transmission of signal to the nucleus
- R-hsa-597592 post translational protein modification
- R-hsa-381426 regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps
- R-hsa-177929 signaling by egfr
- R-hsa-157118 signaling by notch
- R-hsa-1980143 signaling by notch1
- R-hsa-2691230 signaling by notch1 hd domain mutants in cancer
- R-hsa-2644602 signaling by notch1 pest domain mutants in cancer
- R-hsa-2660825 signaling by notch1 t 7 9 notch1 m1580 k2555 translocation mutant
- R-hsa-1980145 signaling by notch2
- R-hsa-9012852 signaling by notch3
- R-hsa-9013694 signaling by notch4
- R-hsa-9006934 signaling by receptor tyrosine kinases
Canonical Pathways
M204 Pid rhodopsin pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
35 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
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Regulatory Interaction Network
13 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ADA10 | O14672 | NOTC2 | Q04721 | Yes | Yes | No | WangCellTalkDBSignaLink3ACSN | ACSN:19601831ACSN:19726682SignaLink3:10423016SignaLink3:23331499ACSN:19704010CellTalkDB:24842903 |
| ADA10 | O14672 | NOTC3 | Q9UM47 | Yes | Yes | No | WangSignaLink3ACSN | SignaLink3:12651094ACSN:19601831ACSN:19726682SignaLink3:23331499ACSN:19704010 |
| TSN33 | Q86UF1 | ADA10 | O14672 | Yes | Yes | No | SIGNORIntAct | IntAct:23091066SIGNOR:30463011IntAct:26686862 |
| ADA10 | O14672 | CADH1 | P12830 | Yes | Yes | No | WangSIGNOR | SIGNOR:26284334 |
| ADA10 | O14672 | BTC | P35070 | Yes | Yes | Yes | WangSIGNOR | SIGNOR:26284334 |
| ELAV4 | P26378 | ADA10 | O14672 | Yes | Yes | No | SIGNOR | SIGNOR:19221430 |
| ELAV2 | Q12926 | ADA10 | O14672 | Yes | Yes | No | SIGNOR | SIGNOR:19221430 |
| ADA10 | O14672 | CD44 | P16070 | Yes | Yes | No | CellTalkDBSIGNOR | CellTalkDB:18971959SIGNOR:26284334 |
| ELAV1 | Q15717 | ADA10 | O14672 | Yes | Yes | No | SIGNOR | SIGNOR:19221430 |
| ELAV3 | Q14576 | ADA10 | O14672 | Yes | Yes | No | SIGNOR | SIGNOR:19221430 |
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Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryWestern blottingFlow cytometry | 1 | 38602325 |
Sequence, Structure & Domains
Sequences
Length
748
Mass
84,142
Sequence
MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O14672-1; Sequence=Displayed; Name=2; IsoId=O14672-2; Sequence=VSP_056401
Alternative Sequence
19..319; Missing (in isoform 2)
3D Structural Models
Turn
397..399; 476..478; 491..495; 505..507; 556..559; 633..636
Helix
230..236; 239..258; 280..284; 289..291; 297..305; 324..326; 374..388; 401..403; 407..411; 428..430; 434..447; 448..450; 571..575; 591..593; 604..606; 614..617; 653..662; 665..669
Beta Strand
219..228; 269..277; 313..322; 329..331; 336..338; 348..350; 359..367; 462..464; 482..484; 509..511; 515..517; 523..525; 529..531; 553..555; 560..563; 566..569; 577..580; 597..600; 630..632; 637..639; 645..647
3D Structure
Electron microscopy (1); X-ray crystallography (2)
Domain & Motif Annotations
Motif
171..178; Cysteine switch; 708..715; SH3-binding; 722..728; SH3-binding
Domain (CC)
The propeptide keeps the metalloprotease in a latent form via a cysteine switch mechanism. This mechanism may be mediated by a highly conserved cysteine (Cys-173) in the propeptide, which interacts and neutralizes the zinc-coordinating HEXGHXXGXXHD catalytic core of the metalloprotease domain. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.; DOMAIN: The Cys-rich region C-terminal to the disintegrin domain functions as a substrate-recognition module, it recognizes the EFNA5-EPHA3 complex but not the individual proteins (By similarity). Both Cys-rich and stalk region are necessary for interaction with TSPAN5, TSPAN10, TSPAN14, TSPAN17, TSPAN33 (PubMed:26668317). Stalk region is sufficient for interaction with TSPAN15 (By similarity).
Domain (FT)
220..456; Peptidase M12B; 457..551; Disintegrin
Region
704..748; Disordered; 734..748; Interaction with AP2A1, AP2A2 and AP2M1
Clinical Relevance
Disease Involvement
Alzheimer diseaseAmyloidosisCancer-related genesDisease variantNeurodegeneration
Related Diseases
Biomarker
Phase 1/2; Investigative
Drugs
Interaction Protein
ENSG00000099282ENSG00000168785
Interaction Count
2
Interaction Dataset
intact_biogrid_bioplexintact_biogrid