Protein detail

ENC1

Ectoderm-neural cortex protein 1 (ENC-1) (Kelch-like protein 37) (Nuclear matrix protein NRP/B) (p53-induced gene 10 protein)

Entry name ENC1	UniProt ID O14682	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information6

Protein Names

Ectoderm-neural cortex protein 1 (ENC-1) (Kelch-like protein 37) (Nuclear matrix protein NRP/B) (p53-induced gene 10 protein)

Protein Function (2)

Cancer-related genes:Candidate cancer biomarkers
Predicted intracellular proteins

Ensembl

ENSG00000171617

Entrez Gene Symbol

ENC1

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Cell SpecificNeutrophilsBlood Cell Specificneutrophil

Function & Pathway5

Protein Function (2)

Cancer-related genes:Candidate cancer biomarkers
Predicted intracellular proteins

Cellular Component (8)

Molecular Function (2)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence6

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
CRL3 E3 ubiquitin ligase complexENC1 variant	CUL3 ENC1 RBX1	O14682 P62877 Q13618	2:2:2	ComplexPortal	intact:EBI-46443579	35580799 36504893 29249570 24959344 14755292

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometryMass spectrometry [QTOF]	0

Sequence, Structure & Domains7

Sequences

Length

589

Mass

66,130

Sequence

MSVSVHENRKSRASSGSINIYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKTGHALFLLGGQTFMCDKLYLVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSITTVPYSLIPTAFVSTWKHLPS

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O14682-1; Sequence=Displayed; Name=2; IsoId=O14682-2; Sequence=VSP_045074

Alternative Sequence

1..73; Missing (in isoform 2)

Domain & Motif Annotations

Repeat

296..340; Kelch 1; 341..388; Kelch 2; 389..444; Kelch 3; 446..492; Kelch 4; 494..538; Kelch 5; 539..585; Kelch 6

Domain (FT)

46..114; BTB

Supporting Publications1

PMID	Title	Abstract
32002171	Activated human astrocyte-derived extracellular vesicles modulate neuronal uptake, differentiation and firing.	No abstract available