Protein detail

RIOK3

Serine/threonine-protein kinase RIO3 (EC 2.7.11.1) (RIO kinase 3) (sudD homolog)

Entry name RIOK3	UniProt ID O14730	EVMP confidence score 0.40
Supporting publications (n) 1	Transmembrane count	Protein classification EnzymesPredicted intracellular proteins

Basic Information

Protein Names

Serine/threonine-protein kinase RIO3 (EC 2.7.11.1) (RIO kinase 3) (sudD homolog)

Protein Class (2)

EnzymesPredicted intracellular proteins

Protein Function (4)

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins
Kinases:Atypical kinases

Ensembl

ENSG00000101782

Entrez Gene Symbol

RIOK3

Gene Synonym

SUDD

Gene Description

RIO kinase 3

Chromosome

Position

23453287-23486603

Supporting publications (n)

EVMP confidence score

0.40

Fluorescence & Localization

Tissue Specificlymphoid tissueCell SpecificNeutrophilsSingle-Nuclei Brain Specificcentral nervous system macrophageSecretome LocationIntracellular and membraneSecretome FunctionEnzyme

Function & Pathway

Protein Function (4)

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins
Kinases:Atypical kinases

Cellular Component (2)

Molecular Function (7)

Biological Process (3)

Reactome (2)

Mediation Categories

Immune mediation

Relations & Evidence11

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database	Receiver
receptor	receptor	OmniPath	Yes
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	UniProt_location
intracellular	intracellular	OmniPath
receptor	receptor	scConnect	Yes

Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
RIOK3	O14730	IFIH1	Q9BYX4	Yes		Yes	Sparser_ProtMapperiPTMnetSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:25865883 ProtMapper:33652597 SIGNOR:25865883 PhosphoSite:25865883 ProtMapper:31379819

Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ATAD3A CAD CANX H1-5 IDH3A KCTD3 MYL12A ODC1 PIK3C2A PTGES3 RIOK3 RPN2 SPTAN1 TNR VCP	O00443 O14730 P04844 P11926 P16401 P19105 P27708 P27824 P50213 P55072 Q13813 Q15185 Q92752 Q9NVI7 Q9Y597	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6988
ATAD3A CHCHD2 CTRL H1-5 IDH3A KCTD3 ODC1 PIK3C2A PTGES3 RIOK3 RPN2 SPTAN1 TNR VCP ZBTB41	O00443 O14730 P04844 P11926 P16401 P40313 P50213 P55072 Q13813 Q15185 Q5SVQ8 Q92752 Q9NVI7 Q9Y597 Q9Y6H1	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6602
ATAD3A CAD CANX CARM1 IDH3A KCTD3 MYL12A ODC1 PIK3C2A PTGES3 RIOK3 RPN2 TNR VCP VDAC3	O00443 O14730 P04844 P11926 P19105 P27708 P27824 P50213 P55072 Q15185 Q86X55 Q92752 Q9NVI7 Q9Y277 Q9Y597	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8138

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometryWestern blottingFlow cytometryELISA	7	30353492 37686366 41201090 30760538 31320591 40091455 39532703

Sequence, Structure & Domains

Sequences

Length

519

Mass

59,093

Sequence

MDLVGVASPEPGTAAAWGPSKCPWAIPQNTISCSLADVMSEQLAKELQLEEEAAVFPEVAVAEGPFITGENIDTSSDLMLAQMLQMEYDREYDAQLRREEKKFNGDSKVSISFENYRKVHPYEDSDSSEDEVDWQDTRDDPYRPAKPVPTPKKGFIGKGKDITTKHDEVVCGRKNTARMENFAPEFQVGDGIGMDLKLSNHVFNALKQHAYSEERRSARLHEKKEHSTAEKAVDPKTRLLMYKMVNSGMLETITGCISTGKESVVFHAYGGSMEDEKEDSKVIPTECAIKVFKTTLNEFKNRDKYIKDDFRFKDRFSKLNPRKIIRMWAEKEMHNLARMQRAGIPCPTVVLLKKHILVMSFIGHDQVPAPKLKEVKLNSEEMKEAYYQTLHLMRQLYHECTLVHADLSEYNMLWHAGKVWLIDVSQSVEPTHPHGLEFLFRDCRNVSQFFQKGGVKEALSERELFNAVSGLNITADNEADFLAEIEALEKMNEDHVQKNGRKAASFLKDDGDPPLLYDE

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O14730-1; Sequence=Displayed; Name=2; IsoId=O14730-2; Sequence=VSP_012164

Alternative Sequence

449..451; Missing (in isoform 2)

3D Structural Models

3D Structure

Electron microscopy (3)

Domain & Motif Annotations

Compositional Bias

124..134; Acidic residues

Domain (CC)

The ubiquitin interaction motif (UIM) specifically recognizes and binds monoubiquitinated RPS2/us5 and RPS3/us3..

Domain (FT)

251..519; Protein kinase

Region

60..105; Ubiquitin interaction motif (UIM); 121..159; Disordered; 167..230; Ribosome-binding region (RBR)

Protein Families (2)

Protein kinase superfamily
RIO-type Ser/Thr kinase family

Sequence Similarities

Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

Clinical Relevance

Antibody (2)

HPA001620 HPA024184

Interaction Protein (5)

ENSG00000003400ENSG00000008988ENSG00000138326ENSG00000140988ENSG00000204628

Interaction Count

Interaction Dataset (2)

intact_biogridbiogrid_opencell

Supporting Publications1

PMID	Title	Related sentences
38716512	Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics.	No related sentences available