Protein detail
MP2K7
Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2)
Protein symbol MP2K7 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification EnzymesPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2)
Protein Class
EnzymesPlasma proteinsPredicted intracellular proteins
Protein Function
- ENZYME proteins:Transferases
- Enzymes
- Kinases:STE Ser/Thr protein kinases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
Jnkk2MKK7PRKMK7
Gene Description
Mitogen-activated protein kinase kinase 7
Chromosome
19
Position
7903843-7914478
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificAstrocytesSingle-Nuclei Brain SpecificastrocyteBlood Cell Specificbasophil
Function & Pathway
Protein Function
- ENZYME proteins:Transferases
- Enzymes
- Kinases:STE Ser/Thr protein kinases
- Predicted intracellular proteins
Cellular Component
Molecular Function
- GO:0000287 magnesium ion binding
- GO:0004707 MAP kinase activity
- GO:0004708 MAP kinase kinase activity
- GO:0004713 protein tyrosine kinase activity
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0008545 JUN kinase kinase activity
- GO:0019899 enzyme binding
- GO:0019901 protein kinase binding
- GO:0019903 protein phosphatase binding
- GO:0106310 protein serine kinase activity
- GO:0140677 molecular function activator activity
Biological Process
KEGG
- hsa04010 MAPK signaling pathway
- KEGG:hsa04012 ErbB signaling pathway
- KEGG:hsa04141 Protein processing in endoplasmic reticulum
- KEGG:hsa04380 Osteoclast differentiation
- KEGG:hsa04530 Tight junction
- KEGG:hsa04620 Toll-like receptor signaling pathway
- KEGG:hsa04660 T cell receptor signaling pathway
- KEGG:hsa04664 Fc epsilon RI signaling pathway
- KEGG:hsa04668 TNF signaling pathway
- KEGG:hsa04722 Neurotrophin signaling pathway
- KEGG:hsa04912 GnRH signaling pathway
- KEGG:hsa04926 Relaxin signaling pathway
- KEGG:hsa04936 Alcoholic liver disease
- KEGG:hsa05010 Alzheimer disease
- KEGG:hsa05016 Huntington disease
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05132 Salmonella infection
- KEGG:hsa05135 Yersinia infection
- KEGG:hsa05161 Hepatitis B
- KEGG:hsa05167 Kaposi sarcoma-associated herpesvirus infection
- KEGG:hsa05169 Epstein-Barr virus infection
- KEGG:hsa05170 Human immunodeficiency virus 1 infection
- KEGG:hsa05208 Chemical carcinogenesis - reactive oxygen species
- KEGG:hsa05417 Lipid and atherosclerosis
- KEGG:hsa05418 Fluid shear stress and atherosclerosis
Reactome
- R-hsa-9824439 bacterial infection pathways
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-2559583 cellular senescence
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-2871796 fceri mediated mapk activation
- R-hsa-2454202 fc epsilon receptor fceri signaling
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-448424 interleukin 17 signaling
- R-hsa-450321 jnk c jun kinases phosphorylation and activation mediated by activated human tak1
- R-hsa-166166 myd88 independent tlr4 cascade
- R-hsa-2559580 oxidative stress induced senescence
- R-hsa-449147 signaling by interleukins
- R-hsa-168138 toll like receptor 9 tlr9 cascade
- R-hsa-168898 toll like receptor cascades
- R-hsa-168179 toll like receptor tlr1 tlr2 cascade
- R-hsa-5339562 uptake and actions of bacterial toxins
- R-hsa-5210891 uptake and function of anthrax toxins
Mediation Categories
Clinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
8 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| MAP2K7 | MAP3K1 | Q13233 | T | 275 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPSIGNORProtMapperReactome_ProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:9312068SIGNOR:9312068KEA:9312068phosphoELM:9312068 |
| MAP2K7 | MAP3K1 | Q13233 | S | 271 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPSIGNORProtMapperReactome_ProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:9312068SIGNOR:9312068KEA:9312068phosphoELM:9312068 |
| MAP2K7 | MAPK10 | P53779 | S | 35 | phosphorylation | PhosphoNetworks | |
| MAP2K7 | RIPK2 | O43353 | S | 53 | phosphorylation | PhosphoNetworks | |
| MAP2K7 | RIPK2 | O43353 | S | 55 | phosphorylation | PhosphoNetworks | |
| MAP2K7 | RIPK2 | O43353 | S | 57 | phosphorylation | PhosphoNetworks | |
| MAP2K7 | MAP3K13 | O43283 | S | 58 | phosphorylation | PhosphoNetworks | |
| MAP2K7 | NEK2 | P51955 | S | 271 | phosphorylation | PhosphoNetworks |
Ligand-Receptor Signaling
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
23 records.
Protein Complex Composition
8 records.
Sequence, Structure & Domains
Sequences
Length
419
Mass
47,485
Sequence
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=A; IsoId=O14733-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=O14733-2; Sequence=VSP_004883; Name=3; Synonyms=gamma1; IsoId=O14733-3; Sequence=VSP_022309; Name=4; IsoId=O14733-4; Sequence=VSP_022310
Alternative Sequence
42; T -> IIVITLSPAPAPSQRAA (in isoform 3); 111; Q -> QVPPSLWRGEGGGPARLDPSWERQWGAGGGGRAPGTLQPSLSSQ (in isoform 2); 312; L -> LPCPSPSQ (in isoform 4)
3D Structural Models
Turn
140..142; 172..175; 262..265; 321..324
Helix
87..100; 117..119; 157..171; 203..210; 216..237; 246..248; 281..283; 286..289; 302..317; 328..337; 351..360; 365..367; 371..374; 378..385; 390..401
Beta Strand
104..108; 111..115; 120..126; 129..138; 145..152; 182..187; 189..196; 200..202; 249..251; 257..259; 294..296; 345..347
3D Structure
X-ray crystallography (37)
Domain & Motif Annotations
Compositional Bias
18..30; Basic and acidic residues; 36..63; Low complexity
Coiled Coil
2..30
Domain (CC)
The DVD domain (residues 377-400) contains a conserved docking site and is found in the mammalian MAP kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation.; DOMAIN: The D domain (residues 37-57) contains a conserved docking site and is required for the binding to MAPK substrates.
Domain (FT)
120..380; Protein kinase
Region
18..76; Disordered; 37..57; D domain; 377..400; DVD domain
Protein Families
- Protein kinase superfamily
- STE Ser/Thr protein kinase family
- MAP kinase kinase subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Clinical Relevance
Drugs
Interaction Protein
ENSG00000099860ENSG00000121653
Interaction Count
2
Interaction Dataset
intact_biogrid