Protein detail
NRP1
Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304)
Entry name NRP1 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 4 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304)
Protein Class (7)
Cancer-related genesCD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters
Protein Function (5)
- Predicted intracellular proteins
- CD markers
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Transporters:Accessory Factors Involved in Transport
Transmembrane
857..879; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
CD304NRPVEGF165R
Gene Description
Neuropilin 1
Chromosome
10
Position
33177492-33336262
Supporting publications (n)
4
EVMP confidence score
0.25
Fluorescence & Localization2
Cell SpecificLate primary spermatocytes
Function & Pathway8
Protein Function (5)
- Predicted intracellular proteins
- CD markers
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Transporters:Accessory Factors Involved in Transport
Cellular Component (15)
- GO:0002116 semaphorin receptor complex
- GO:0005615 extracellular space
- GO:0005769 early endosome
- GO:0005829 cytosol
- GO:0005883 neurofilament
- GO:0005886 plasma membrane
- GO:0005925 focal adhesion
- GO:0030424 axon
- GO:0031410 cytoplasmic vesicle
- GO:0031966 mitochondrial membrane
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Molecular Function (11)
- GO:0005021 vascular endothelial growth factor receptor activity
- GO:0005096 GTPase activator activity
- GO:0005515 protein binding
- GO:0008201 heparin binding
- GO:0015026 coreceptor activity
- GO:0017154 semaphorin receptor activity
- GO:0019838 growth factor binding
- GO:0019901 protein kinase binding
- GO:0019955 cytokine binding
- GO:0038085 vascular endothelial growth factor binding
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Biological Process (3)
KEGG (4)
Reactome (17)
- R-hsa-9694614 attachment and entry
- R-hsa-447041 chl1 interactions
- R-hsa-399956 crmps in sema3a signaling
- R-hsa-9772572 early sars cov 2 infection events
- R-hsa-5663205 infectious disease
- R-hsa-373760 l1cam interactions
- R-hsa-9675108 nervous system development
- R-hsa-9694516 sars cov 2 infection
- R-hsa-9679506 sars cov infections
- R-hsa-399954 sema3a pak dependent axon repulsion
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Canonical Pathways (3)
- M201 Pid erbb network pathway
- M175 Pid erbb2 erbb3 pathway
- M239 Pid a6b1 a6b4 integrin pathway
Mediation Categories (5)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence87
Ligand-Receptor Signaling (72)
72 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | GO_Intercell | No | No | Yes | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | Yes | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | Yes | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | Yes | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | Yes | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | Yes | Yes | No |
Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SEM3A | Q14563 | NRP1 | O14786 | Yes | Yes | Yes | iTALKICELLNETSIGNORDIPHPMR_talklrHPMRHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019STRING_talklrEMBRACECellTalkDBFantom5_LRdbconnectomeDB2020LRdb | LRdb:9331348LRdb:15721238HPMR:10520994HPMR:15721238DIP:10498602CellTalkDB:10520994Baccin2019:10520994HPRD:9331348Baccin2019:15721238HPRD:10520994HPMR:15121181SIGNOR:10196546connectomeDB2020:15721238LRdb:10520994ICELLNET:29067024connectomeDB2020:9331348Baccin2019:9331348SIGNOR:25335892HPMR:15814794connectomeDB2020:10520994 |
| SEM3B | Q13214 | NRP1 | O14786 | Yes | Yes | No | WangFantom5_LRdbCellTalkDBHPMR_LRdbHPRD_LRdbiTALKtalklrRamilowski2015SIGNORconnectomeDB2020HPRDHPRD_talklrSPIKE_LCLRdbHPMR_talklr | CellTalkDB:10196546LRdb:10196546connectomeDB2020:10196546SIGNOR:25335892HPRD:10196546SPIKE_LC:16189514 |
Protein Complex Composition (12)
12 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CoV2 spike protein-NRP1 | NRP1P0DTC2 | O14786P0DTC2 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C267 | |
| NRP1-VEGF(165/121) complex | NRP1VEGFA | O14786P15692 | 1:1 | Compleat | Compleat:HC2316 | 17575273 |
| NRP1-VEGFC complexheparin dependent | NRP1VEGFC | O14786P49767 | 1:1 | CompleatCORUM | Compleat:HC2327CORUM:5731 | 16816121 |
| NRP1-VEGFD complexheparin dependent | NRP1VEGFD | O14786O43915 | 1:1 | CompleatCORUM | Compleat:HC3028CORUM:5734 | 16816121 |
| PlexinB1-Nrp1 complex | NRP1PLXNB1 | O14786O43157 | 1:1 | CompleatCORUM | Compleat:HC2872CORUM:5670 | 10520995 |
| VEGFA(165)-VEGFR2-NRP1 complex | KDRNRP1VEGFA | O14786P15692P35968 | 1:1:1 | Compleat | Compleat:HC683 | 18628209 |
| NRP1 | O14786 | 2 | PDB | PDB:5iyyPDB:5jgiPDB:9f6bPDB:5jhkPDB:5jgqPDB:5j1xPDB:8pfePDB:5ijrPDB:5l73PDB:3i97PDB:7p5u | ||
| IGHG1IGKCNRP1 | O14786P01834P01857 | 1:1:1 | PDB | PDB:2qqn | ||
| NRP1SPP1 | O14786P10451 | 1:1 | PDB | PDB:9eou | ||
| NRP1VEGFB | O14786P49765 | 1:1 | PDB | PDB:6tkk |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry [LTQ-FT Ultra] | 0 |
Sequence, Structure & Domains14
Sequences
Length
923
Mass
103,134
Sequence
MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFVPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDNHVQLKWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHISQEDCAKPADLDKKNPEIKIDETGSTPGYEGEGEGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNTQSTYSEA
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Membrane-bound; IsoId=O14786-1; Sequence=Displayed; Name=2; Synonyms=Soluble, SNRP1; IsoId=O14786-2; Sequence=VSP_004339, VSP_004340; Name=3; IsoId=O14786-3; Sequence=VSP_053498, VSP_004339, VSP_004340
Alternative Sequence
587..621; Missing (in isoform 3); 642..644; EFP -> GIK (in isoform 2 and isoform 3); 645..923; Missing (in isoform 2 and isoform 3)
3D Structural Models
Turn
161..164; 218..220; 273..275; 281..283; 347..349; 437..439; 450..453; 464..466; 506..508; 646..648; 686..689; 806..808
Helix
180..182; 288..290; 299..301; 303..306; 426..428; 444..446; 459..462; 643..645; 699..701
Beta Strand
149..151; 153..159; 172..178; 185..193; 208..217; 223..227; 235..238; 240..248; 257..264; 284..286; 291..294; 318..321; 326..342; 352..368; 369..371; 373..378; 385..389; 391..414; 417..424; 447..449; 471..473; 485..502; 515..525; 534..537; 544..547; 550..566; 570..572; 576..584; 667..671; 674..677; 680..682; 690..696; 705..713; 720..728; 733..742; 744..746; 749..757; 761..770; 777..785; 792..800; 809..811
3D Structure
X-ray crystallography (25)
Domain & Motif Annotations
Domain (CC)
The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding. F5/8 domains mediate the recognition and binding to R/KXXR/K CendR motifs (PubMed:19805273, PubMed:33082294).
Domain (FT)
27..141; CUB 1; 147..265; CUB 2; 275..424; F5/8 type C 1; 431..583; F5/8 type C 2; 645..811; MAM
Region
820..845; Disordered
Protein Families
Neuropilin family
Sequence Similarities
Belongs to the neuropilin family.
Clinical Relevance8
Disease Involvement
Cancer-related genes
Related Diseases (2)
Biomarker
Approved; Phase 1
Drugs (4)
Interaction Protein (2)
ENSG00000112715ENSG00000128052
Interaction Count
2
Interaction Dataset
intact_biogrid
Supporting Publications4
| PMID | Title | Abstract |
|---|---|---|
| 30760538 | Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection. | No abstract available |
| 31508500 | Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping. | No abstract available |
| 33729255 | A new urinary exosome enrichment method by a combination of ultrafiltration and TiO2 nanoparticles. | No abstract available |
| 39290459 | Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease. | No abstract available |